2. Oligonucleotides
  3. Nucleosides and their Analogs

Nucleosides and their Analogs

Nucleosides are important biological molecules that function as signaling molecules and as precursors to nucleotides needed for DNA and RNA synthesis. Nucleosides are glycosylamines that can be thought of as nucleotides without a phosphate group. A nucleoside consists simply of a nucleobase (also termed a nitrogenous base) and a five-carbon sugar (either ribose or deoxyribose). Examples of nucleosides include cytidine, uridine, adenosine, guanosine, thymidine and inosine.

 

Nucleosides and their Analogs (1385):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-15910
    5-BrdU 59-14-3 99.96%
    5-BrdU (BrdU) is a nucleoside analog that competes with thymidine for incorporation into DNA. 5-BrdU is commonly used in the detection of proliferating cells.
    5-BrdU
  • HY-B1449
    Uridine 58-96-8 99.98%
    Uridine (β-Uridine) is a nucleoside compound composed of uracil and a ribose ring, which are connected by a β-N1-glycosidic bond.
    Uridine
  • HY-19528
    SAH 979-92-0 99.89%
    SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 µM.
    SAH
  • HY-14392
    5,6-Dichlorobenzimidazole riboside 53-85-0 99.95%
    5,6-Dichlorobenzimidazole riboside (DRB) is a nucleoside analog that inhibits several carboxyl-terminal domain kinases, including casein kinase II and cell cycle-dependent kinases (CDK). 5, 6-dichlorobenzimidazole riboside has antitumor activity. 5, 6-dichlorobenzimidazole riboside can induce apoptosis.
    5,6-Dichlorobenzimidazole riboside
  • HY-W011793
    4-Thiouridine 13957-31-8 99.23%
    4-Thiouridine is a ribonucleoside analog, it is widely used in RNA analysis and (m)RNA labeling. 4-Thiouridine inhibits rRNA synthesis and causes a nucleolar stress response.
    4-Thiouridine
  • HY-W022290
    5-Bromocytidine 3066-86-2
    5-Bromocytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5-Bromocytidine
  • HY-E70441
    Guanosine kinase 55467-46-4
    Guanosine kinase can be used to catalyze the formation of GMP from ATP and guanosine.
    Guanosine kinase
  • HY-N0097
    Guanosine 118-00-3 99.65%
    Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity.
    Guanosine
  • HY-B0158
    Cytidine 65-46-3 99.97%
    Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function.
    Cytidine
  • HY-17563
    2'-Deoxyguanosine 961-07-9 99.90%
    2’-Deoxyguanosine (Deoxyguanosine) is a purine nucleoside with a variety of biological activities. 2’-Deoxyguanosine can induce DNA division in mouse thymus cells. 2’-Deoxyguanosine is a potent cell division inhibitor in plant cells.
    2'-Deoxyguanosine
  • HY-18762
    6-Thio-2'-Deoxyguanosine 789-61-7 99.70%
    6-Thio-2'-Deoxyguanosine is a nucleoside analogue that can be incorporated into de novo-synthesized telomeres by telomerase.
    6-Thio-2'-Deoxyguanosine
  • HY-D0184
    2'-Deoxycytidine 951-77-9 99.95%
    2'-Deoxycytidine, a deoxyribonucleoside, can inhibit biological effects of Bromodeoxyuridine (Brdu). 2'-Deoxycytidine is essential for the synthesis of nucleic acids, that can be used for the research of cancer.
    2'-Deoxycytidine
  • HY-W011527
    Xanthosine 146-80-5 99.96%
    Xanthosine is a nucleoside derived from xanthine and ribose. Xanthosine activates the AMPK/FoxO1/AKT/GSK3β signaling cascade. Xanthosine promotes cell proliferation and regulates blood glucose metabolism. Xanthosine increases milk production in cows and goats. Xanthosine is used in mammary stem cell and type 2 diabetes research.
    Xanthosine
  • HY-113061
    Pseudouridine 1445-07-4 99.93%
    Pseudouridine is an isomer of uridine and the most abundant modified nucleoside in non-coding RNA. It fine-tunes and stabilizes regional structures in rRNA and tRNA, maintaining their functions in mRNA decoding, ribosome assembly, processing, and translation. Pseudouridine-modified tRNA fragments can inhibit aberrant protein synthesis and hold promise for research on myelodysplastic syndrome (MDS)-related leukemia..
    Pseudouridine
  • HY-15345
    Tetrahydrouridine dihydrate 99.86%
    Tetrahydrouridine dihydrate (THU dihydrate) is potent inhibitor of cytidine deaminase (CDA), which competitively blocks the enzyme's active site more effectively than intrinsic cytidine.
    Tetrahydrouridine dihydrate
  • HY-W040329
    2'-Deoxyadenosine 958-09-8 99.99%
    2′-Deoxyadenosine is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine inhibits the growth of various cells. 2'-Deoxyadenosine has an anticancer effect on colon cancer.
    2'-Deoxyadenosine
  • HY-W011540
    8-Hydroxy-2'-deoxyguanosine 88847-89-6 99.61%
    8-Hydroxy-2'-deoxyguanosine is a critical biomarker of oxidative stress and carcinogenesis.
    8-Hydroxy-2'-deoxyguanosine
  • HY-112582
    N1-Methylpseudouridine 13860-38-3 99.97%
    N1-methyl-pseudouridine (1-Methylpseudouridine), a methylpseudouridine, outperforms 5 mC and 5 mC/N1-methyl-pseudouridine in translation. N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density.
    N1-Methylpseudouridine
  • HY-W010450
    Thymine 65-71-4 99.98%
    Thymine, one of the four bases of DNA, is a substrate for rat liver dihydropyrimidine dehydrogenase (DPD), with a Km value of 2.2 μM, Ki of 24 μM (using 5-FU as the DPD substrate), and a specific activity of 0.68 nmol/min/mg.
    Thymine
  • HY-123055
    Adenosine dialdehyde 34240-05-6 ≥99.0%
    Adenosine dialdehyde, a purine nucleoside analogue, is a potent inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) (Ki=3.3 nM). Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo and can be used for the cancer research.
    Adenosine dialdehyde