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FD44 is a phenothiazine small molecule that inhibits the interaction between neuronal calcium sensor 1 (NCS-1) and the guanine exchange factor Ric8a, a key regulator of synapse number and neurotransmitter release probability. In the Drosophila genetic autism model of fragile X syndrome (FXS), FD44 restored normal synapse number and associative learning.

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FD44 Chemical Structure

FD44 Chemical Structure

CAS No. : 68207-21-6

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FD44 Related Antibodies

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Description

FD44 is a phenothiazine small molecule that inhibits the interaction between neuronal calcium sensor 1 (NCS-1) and the guanine exchange factor Ric8a, a key regulator of synapse number and neurotransmitter release probability. In the Drosophila genetic autism model of fragile X syndrome (FXS), FD44 restored normal synapse number and associative learning[1].

Molecular Weight

339.45

Formula

C19H21N3OS
CAS No.
SMILES

O=C(CN1CCCCC1)NN2C3=C(SC4=C2C=CC=C4)C=CC=C3
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
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FD44 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FD4468207-21-6FD 44FD-44OthersInhibitorinhibitorinhibit

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