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Results for "

G-quadruplex (G4)

" in MedChemExpress (MCE) Product Catalog:

20

Inhibitors & Agonists

2

Fluorescent Dye

1

Natural
Products

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-135776
    BMVC2

    o-BMVC

    		 G-quadruplex Cancer
    BMVC2 (o-BMVC) is a bisubstitute carbazole derivative of BMVC. BMVC2 is a G-quadruplex (G4) stabilizer .
    BMVC2
  • HY-15595A
    360A iodide
    2 Publications Verification

    360 A iodide

    		 G-quadruplex Telomerase Cancer
    360A iodide is a selective stabilizer of G-quadruplex, and also inhibits telomerase activity with an IC50 of 300 nM for telomerase in TRAP-G4 assay.
    360A iodide
  • HY-15594A
    Phen-DC3 Trifluoromethanesulfonate
    5 Publications Verification

    Phen-DC3 Triflate

    		 G-quadruplex Cancer
    Phen-DC3 Trifluoromethanesulfonate is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC50s of 65±6 and 50±10 nM, respectively.
    Phen-DC3 Trifluoromethanesulfonate
  • HY-135775
    BMVC
    1 Publications Verification

    		 G-quadruplex Telomerase DNA/RNA Synthesis Cancer
    BMVC is a potent G-quadruplex (G4) stabilizer and a selective telomerase inhibitor with an IC50 of ~0.2 μM. BMVC inhibits Taq DNA polymerase with an IC50 of ~2.5 μM. BMVC increases the melting temperature of G4 structure of telomere and accelerates telomere length shortening. Anticancer activities .
    BMVC
  • HY-151471
    Anticancer agent 84

    		c-Myc Cancer
    Anticancer agent 84 is an anticancer agent. Anticancer agent 84 represses the transcription of c-MYC by stabilizing the G-quadruplex (G4) structure. Anticancer agent 84 can be used for the research of cancer .
    Anticancer agent 84
  • HY-15595
    360A

    		G-quadruplex Telomerase Cancer
    360A is a selective stabilizer of G-quadruplex, and also inhibits telomerase activity with an IC50 of 300 nM for telomerase in TRAP-G4 assay.
    360A
  • HY-152538
    Antitumor agent-85

    		G-quadruplex Cancer
    Antitumor agent-85 is a G-quadruplex (G4)-ligand with the ability to stabilize different G4-DNA structures. Antitumor agent-85 has highly effective anti-tumor properties .
    Antitumor agent-85
  • HY-152537
    Antitumor agent-84

    		G-quadruplex Cancer
    Antitumor agent-84 (compound 21a) is a G-quadruplex (G4)-ligand with the ability to stabilize different G4-DNA structures. Antitumor agent-84 has highly effective anti-tumor properties .
    Antitumor agent-84
  • HY-15594
    Phen-DC3

    		DNA/RNA Synthesis Cancer
    Phen-DC3 is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC50s of 65±6 and 50±10 nM, respectively.
    Phen-DC3
  • HY-161693
    Telomeric G4s ligand 1

    		G-quadruplex DNA/RNA Synthesis Apoptosis Cancer
    Telomeric G4s ligand 1 is a telomeric G-quadruplex ligand that stabilizes telomeric G4 and induces R-loop formation, leading to DNA damage responses. Telomeric G4s ligand 1 induces apoptosis and evokes immunogenic cell death (ICD) in tumor cells .
    Telomeric G4s ligand 1
  • HY-145843
    c-Myc inhibitor 5

    		c-Myc Cancer
    c-Myc inhibitor 5 (DA3) is a fluorescent, long chain-bridged bispurine that selectively targets the c-MYC G-quadruplex (KD of 16 μM). c-Myc inhibitor 5 shows inhibition on c-MYC expression rather than other G4-driven oncogenes .
    c-Myc inhibitor 5
  • HY-158126
    G-quadruplex ligand 2

    		DNA/RNA Synthesis Cancer
    G-quadruplex ligand 2 (compound A3) is a triphenylamine-based ligand that targets mitochondrial DNA G4s. G-quadruplex ligand 2 activates the cGAS-STING pathway. G-quadruplex ligand 2 inhibits tumor growth and metastasis via regulation of TME .
    G-quadruplex ligand 2
  • HY-135009
    2-Di-1-ASP

    DASPI

    		 G-quadruplex Others
    2-Di-1-ASP (DASPI; Compound 18a) is a mono-stryryl dye, and widely used as mitochondrial stain and groove-binding fluorescent probes for double-stranded DNA. 2-Di-1-ASP is selective for G-quadruplex (G4) and double-stranded DNA .
    2-Di-1-ASP
  • HY-144712
    L5-DA

    		G-quadruplex Apoptosis Cancer
    L5-DA is a G-quadruplex (G4) ligand and selectively stabilized for G4s over ds26. L5-DA exhibits significant cytotoxicity against HeLa cells (IC50=4.3 μM). L5-DA stabilizes G4s in HeLa cells, induces apoptosis, and cell cycle arrest .
    L5-DA
  • HY-111297
    BMVC4

    		Others Cancer
    BMVC4 is a G-quadruplex (G4) stabilizer of the human telomeric sequence d[AG3(T2AG3)3]. Screening by circular dichroism (CD) spectroscopy revealed that BMVC4 is more suitable as the core molecule of G4 stabilizers than BMVC. The results showed that BMVC4-12C and BMVC4-8C3O are better candidates for G4 stabilizers and are worthy of further study. A simple and rapid screening method based on Cu2+-induced G4 unfolding can be used to find better G4 stabilizers for potential anticancer applications. CD results showed that the trivalent cations of 9-substituted BMVC derivatives are more suitable as G4 stabilizers than the divalent cations of BMVC. In addition, by monitoring the disappearance of the 291 nm CD band of human telomeres after Cu2+ addition, it was found that the core molecule of G4 stabilizer BMVC4 has better stability.
    BMVC4
  • HY-D2380
    H2S probe 1

    		G-quadruplex Cancer
    H2S probe 1 (compound 1NND) is a derivative of nitrobenzoxadiazole (NBD) with antitumor activity. H2S probe 1 is cytotoxic to human pancreatic cancer cell MIA PaCa-2 (IC50=77.9 nM) and has a high affinity for human telomeric G-quadruplex (G4) (Kd=1.72 μM). H2S probe 1 can be used in cancer research .
    H2S probe 1
  • HY-162688
    Anticancer agent 239

    		Telomerase G-quadruplex Apoptosis Ferroptosis Others
    Anticancer agent 239 (Compound 5) is a ligand of hTERT promoter G-quadruplex DNA structures (hTERT G4) (Kd = 1.1 μM), and downregulates hTERT expression. Anticancer agent 239 decreases telomerase activity, shortens telomere length, and induces DNA damage, acute cellular senescence, and apoptosis. Anticancer agent 239 causes mitochondrial dysfunction, disrupts iron metabolism and activates ferroptosis in cancer cells. Anticancer agent 239 inhibits tumor growth in MDA-MB-231 xenograft mouse model .
    Anticancer agent 239
  • HY-112680
    Carboxypyridostatin

    		G-quadruplex Cancer
    Carboxypyridostatin is a G-quadruplex ligand that has a highly molecular specificity to RNA on DNA G4s, and can reduce the proliferation of adult neural stem cells and progenitor cells derived from the subventricular zone of adult mice in vitro and in vivo .
    Carboxypyridostatin
  • HY-112680A
    Carboxy pyridostatin trifluoroacetate salt
    2 Publications Verification

    		 G-quadruplex Cancer
    Carboxy pyridostatin trifluoroacetate salt is a G-quadruplex ligand that has a highly molecular specificity to RNA on DNA G4s, and can reduce the proliferation of adult neural stem cells and progenitor cells derived from the subventricular zone of adult mice in vitro and in vivo .
    Carboxy pyridostatin trifluoroacetate salt
  • HY-N10579
    Chrexanthomycin C

    		DNA/RNA Synthesis Neurological Disease
    Chrexanthomycin C is an orally active marine natural product with remarkable bioactivities. Chrexanthomycin C has binding affinity for DNA (G4C2) 4 G4 with a Kd value of 2.8 mM. Chrexanthomycin C can be used for the research of neurodegenerative disease such as amyotrophic lateral sclerosis (ALS) .
    Chrexanthomycin C

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