2. Cell Cycle/DNA Damage
  3. G-quadruplex Telomerase DNA/RNA Synthesis
  4. BMVC

BMVC is a potent G-quadruplex (G4) stabilizer and a selective telomerase inhibitor with an IC50 of ~0.2 μM. BMVC inhibits Taq DNA polymerase with an IC50 of ~2.5 μM. BMVC increases the melting temperature of G4 structure of telomere and accelerates telomere length shortening. Anticancer activities.

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BMVC Chemical Structure

BMVC Chemical Structure

CAS No. : 627810-06-4

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Based on 1 publication(s) in Google Scholar

BMVC Related Antibodies

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Description

BMVC is a potent G-quadruplex (G4) stabilizer and a selective telomerase inhibitor with an IC50 of ~0.2 μM. BMVC inhibits Taq DNA polymerase with an IC50 of ~2.5 μM. BMVC increases the melting temperature of G4 structure of telomere and accelerates telomere length shortening. Anticancer activities[1][2].

IC50 & Target

IC50: ~0.2 μM (Telomerase)[1]
G-quadruplex[1]
IC50: ~2.5 μM (Taq DNA polymerase)[1]
In Vitro

BMVC (0.5 μM; 0-18 days; H1299 cells) treatment markedly increases the percentage of sub-G1-phase cells after 18 days[1].
BMVC (0.5 μM; 0-18 days; H1299 cells) long-term treatment leads to ceasing of cell growth and eventually cell death through apoptosis. The long-term BMVC treatment induces senescence program in H1299 cells[1].
In BMVC-treated cancer cells, hallmarks of senescence, including morphologic changes, detection of senescence-associated β-galactosidase activity, and decreasesd bromodeoxyuridine incorporation, are detected. The BMVC-induced senescence phenotype is accompanied by progressive telomere shortening and detection of the DNA damage foci, indicating that BMVC caused telomere uncapping after long-term treatments[1].
BMVC also suppresses the tumor-related properties of cancer cells, including cell migration, colony-forming ability, and anchorage-independent growth[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BMVC Related Antibodies

Cell Cycle Analysis[1]

Cell Line: H1299 cells
Concentration: 0.5 μM
Incubation Time: 0 day, 6 days, 12 days, 18 days
Result: The percentage of sub-G1-phase cells was markedly increased after 18 days.

Apoptosis Analysis[1]

Cell Line: H1299 cells
Concentration: 0.5 μM
Incubation Time: 0 day, 6 days, 12 days, 18 days
Result: Increased apoptotic cells.
In Vivo

BMVC (1 mg/kg; intraperitoneal injection; every 3 day; BALB/cAnN.Cg-Foxn1nu/CrlNarl mice) treatment delays tumorigenic potential of cancer cells in vivo[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/cAnN.Cg-Foxn1nu/CrlNarl mice injected with H1299 cells[1]
Dosage: 1 mg/kg
Administration: Intraperitoneal injection; every 3 day
Result: The growth rates of tumors in animals were significantly slower than that of control animals. The tumor cells of the mice were indeed entering apoptosis.
Molecular Weight

657.33

Formula

C28H25I2N3
CAS No.
Appearance

Solid

Color

Orange to red

SMILES

C[N+]1=CC=C(/C=C/C2=CC3=C(C=C2)NC4=C3C=C(/C=C/C5=CC=[N+](C)C=C5)C=C4)C=C1.[I-].[I-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (15.21 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5213 mL 7.6065 mL 15.2131 mL
5 mM 0.3043 mL 1.5213 mL 3.0426 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5213 mL 7.6065 mL 15.2131 mL 38.0326 mL
5 mM 0.3043 mL 1.5213 mL 3.0426 mL 7.6065 mL
10 mM 0.1521 mL 0.7607 mL 1.5213 mL 3.8033 mL
15 mM 0.1014 mL 0.5071 mL 1.0142 mL 2.5355 mL
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BMVC Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMVC627810-06-4G-quadruplexTelomeraseDNA/RNA SynthesisAnticancercarbazoleapoptosissenescenceβ-galactosidaseDNAdamagetelomeremigrationcolony-formingInhibitorinhibitorinhibit

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