2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. Chrexanthomycin C

Chrexanthomycin C is an orally active marine natural product with remarkable bioactivities. Chrexanthomycin C has binding affinity for DNA (G4C2)4 G4 with a Kd value of 2.8 mM. Chrexanthomycin C can be used for the research of neurodegenerative disease such as amyotrophic lateral sclerosis (ALS).

For research use only. We do not sell to patients.

Chrexanthomycin C Chemical Structure

Chrexanthomycin C Chemical Structure

CAS No. : 3030587-55-1

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Chrexanthomycin C Related Antibodies

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Description

Chrexanthomycin C is an orally active marine natural product with remarkable bioactivities. Chrexanthomycin C has binding affinity for DNA (G4C2)4 G4 with a Kd value of 2.8 mM. Chrexanthomycin C can be used for the research of neurodegenerative disease such as amyotrophic lateral sclerosis (ALS)[1].

IC50 & Target

Kd: 2.8 mM (DNA (G4C2)4 G4)[1]
In Vitro

Chrexanthomycin C (Compounds cC) (0.1-10 mM) binds DNA (G4C2)4 G4 with a Kd value of 2.8 mM[1].
Chrexanthomycin C has good permeability, low cytotoxicity, and nonhemolytic activity[1].
Chrexanthomycin C (1.57 μM) rescues G4C2 EHR-related pathologies in cells[1].
Chrexanthomycin C selectively binds to DNA and RNA G4C2 G4s[1].
Chrexanthomycin C (0-100 μM) dramatically reduceS G4C2 EHR-caused cell death, diminish G4C2 RNA foci in (G4C2)29-expressing Neuro2a cells, and significantly eliminate ROS in HT22 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chrexanthomycin C Related Antibodies

Cell Viability Assay[1]

Cell Line: HEK293T cells
Concentration: 0.16, 1.57 and 15.67 μM
Incubation Time: 24 h
Result: Showed no cytotoxicity up to the concentration of 10 μg/mL.
In Vivo

Chrexanthomycin C (Compounds cC) (fed; 100 μM) significantly rescues eye degeneration and improve locomotor deficits in (G4C2)29-expressing[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Drosophila[1]
Dosage: 100 μM
Administration: fed
Result: Rescued G4C2 EHR-Related Pathologies in Drosophila.
Molecular Weight

638.53

Formula

C31H26O15
CAS No.
SMILES

OC1=C2C3=C(O)C(C(O)=O)=C(CC(C)=O)C=C3CCC2=C(C4=C1C(C5=CC=CC(O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O)O)O)C(O)=O)=C5O4)=O)O
Structure Classification
Initial Source

Streptomyces chrestomyceticus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Chrexanthomycin C Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chrexanthomycin C3030587-55-1DNA/RNA SynthesisG-quadruplex (G4)C9orf72 GGGGCC (G4C2)expanded hexanucleotide repeat (EHR)amyotrophic lateral sclerosis (ALS)frontotemporal dementia (FTD)neurodegenerative diseaseInhibitorinhibitorinhibit

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