2. Cell Cycle/DNA Damage Apoptosis
  3. G-quadruplex DNA/RNA Synthesis Apoptosis
  4. Telomeric G4s ligand 1

Telomeric G4s ligand 1 is a telomeric G-quadruplex ligand that stabilizes telomeric G4 and induces R-loop formation, leading to DNA damage responses. Telomeric G4s ligand 1 induces apoptosis and evokes immunogenic cell death (ICD) in tumor cells.

For research use only. We do not sell to patients.

Telomeric G4s ligand 1 Chemical Structure

Telomeric G4s ligand 1 Chemical Structure

CAS No. : 3047091-81-3

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Telomeric G4s ligand 1 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Telomeric G4s ligand 1 is a telomeric G-quadruplex ligand that stabilizes telomeric G4 and induces R-loop formation, leading to DNA damage responses. Telomeric G4s ligand 1 induces apoptosis and evokes immunogenic cell death (ICD) in tumor cells[1].

In Vitro

Telomeric G4s ligand 1 (compound R1; 1-4 μM; 24 h) could stabilize G4 and induce R-loop structures in the telomeric regions of MDA-MB-231 cells, which triggered DNA damage responses, cell cycle arrest in G2/M phase, apoptosis and antiproliferation[1].
Telomeric G4s ligand 1 evokes immunogenic cell death (ICD) in tumor cells, which promoted the maturation of bone marrow derived dendritic cells (BMDCs)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Telomeric G4s ligand 1 Related Antibodies

Cell Cycle Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 1 μM, 2 μM, 4 μM
Incubation Time: 24 h
Result: Induced cell cycle arrest in G2/M phase and apoptosis.

Western Blot Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 1 μM, 2 μM, 4 μM
Incubation Time: 24 h
Result: Increased the levels of DNA damage-related proteins, such as γH2AX and replication protein A subunit.
In Vivo

Telomeric G4s ligand 1 (compound R1; 10 mg/kg; ip; every other day for 14 days) exhibits a significant decrease in tumor burden through the immunomodulatory effects, including the increase of CD4+ and CD8+ T cells in tumors and cytokine levels in sera in breast cancer mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4-week-old female BALB/c mice injected 4T1 cells[1]
Dosage: 10 mg/kg
Administration: ip; every other day for 14 days
Result: Exhibited the ability to lengthen the survival time of tumor-bearing mice, and resulted in DNA damage and apoptosis in vivo.
Molecular Weight

550.66

Formula

C31H37F3N6
CAS No.
SMILES

CN(CCN(C)C)C1=CC=C(C2=C(C3=CC=C(N(C)CCN(C)C)C=C3)N=C(C=CC(C(F)(F)F)=C4)C4=N2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Telomeric G4s ligand 1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Telomeric G4s ligand 13047091-81-3G-quadruplexDNA/RNA SynthesisApoptosistelomeric G-quadruplex ligandDNA damageR-loop formationapoptosiscell cycle arrest in G2/M phaseInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Telomeric G4s ligand 1
Cat. No.:
HY-161693
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (0 KB) Français - FR (0 KB) Deutsch - DE (0 KB) Norwegian - NO (0 KB) Español - ES (0 KB) Swedish - SV (0 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.