Carboxypyridostatin

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Carboxypyridostatin is a G-quadruplex ligand. Carboxypyridostatin has a highly molecular specificity to RNA on DNA G4s and reduces ATF-5 protein. Carboxypyridostatin reduces cell proliferation and hinders stress granule (SG) formation.

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Carboxypyridostatin Chemical Structure

CAS No. : 1417638-60-8

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Other Forms of Carboxypyridostatin:

Carboxy pyridostatin trifluoroacetate salt Get quote

3 Publications Citing Use of MCE Carboxypyridostatin

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Biological Activity
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Description

In Vitro

Carboxypyridostatin (1-25 μM; 3 days) reduces the size of adult SVZ-derived neurospheres and the number of cells in neurospheres, and blocks proliferation and neurosphere fusion in adult SVZ-derived neurosphere cultures^[1].
Carboxypyridostatin (10 μM; 24 h) hinders stress granule (SG) formation in U2OS cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Carboxypyridostatin (10 mg/kg; i.p.; every 12 h; 3 injections) significantly reduces the number of PCNA-expressing cells in the adult SVZ and increases the number of OLIG2-expressing cells in the corpus callosum in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 mice (both sexes, 1-2 months old)^[1]
Dosage:	10 mg/kg (dissolved in phosphate-buffered saline)
Administration:	Intraperitoneal injection, every 12 h, 3 injections
Result:	Reduced the number of PCNA-expressing cells in the adult SVZ of mice, indicating a decrease in cell proliferation. Increased the number of OLIG2-expressing cells in the corpus callosum. Showed no increase in OLIG2-expression in the SVZ. Affected the differentiation of neural stem and progenitor cells in different brain regions.

Molecular Weight

706.71

Formula

C₃₅H₃₄N₁₀O₇

CAS No.

1417638-60-8

SMILES

O=C(O)CCN1N=NC(COC2=CC(C(NC3=NC4=CC=CC=C4C(OCCN)=C3)=O)=NC(C(NC5=NC6=CC=CC=C6C(OCCN)=C5)=O)=C2)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Goldberg DC, et al. Manipulating Adult Neural Stem and Progenitor Cells with G-Quadruplex Ligands. ACS Chem Neurosci. 2020;11(10):1504-1518. [Content Brief]

[2]. Rocca R, et al. Molecular recognition of a carboxy pyridostatin toward G-quadruplex structures: Why does it prefer RNA? Chem Biol Drug Des. 2017 Nov;90(5):919-925. [Content Brief]

[3]. Turner M, et al. rG4detector, a novel RNA G-quadruplex predictor, uncovers their impact on stress granule formation. Nucleic Acids Res. 2022 Nov 11;50(20):11426-11441. [Content Brief]