Carboxy pyridostatin trifluoroacetate salt

Name: Carboxy pyridostatin trifluoroacetate salt
Brand: MedChemExpress
SKU: HY-112680A
Rating: 5.0 (3 reviews)

Cat. No.: HY-112680A Purity: 95.85%: Data Sheet
SDS

COA
Handling Instructions Technical Support

Solubility

In Vivo Dissolution Calculator

Carboxy pyridostatin trifluoroacetate salt is a G-quadruplex ligand. Carboxy pyridostatin trifluoroacetate salt has a highly molecular specificity to RNA on DNA G4s and reduces ATF-5 protein. Carboxy pyridostatin trifluoroacetate salt reduces cell proliferation and hinders stress granule (SG) formation.

For research use only. We do not sell to patients.

Carboxy pyridostatin trifluoroacetate salt Chemical Structure

CAS No. : 2444713-88-4

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 841	In-stock	Estimated Time of Arrival: June 2
Solution
10 mM * 1 mL in DMSO	USD 885	In-stock	Estimated Time of Arrival: June 2
Solid
1 mg	USD 280	In-stock	Estimated Time of Arrival: June 2
5 mg	USD 580	In-stock	Estimated Time of Arrival: June 2
10 mg	USD 980	In-stock	Estimated Time of Arrival: June 2
25 mg	USD 1900	In-stock	Estimated Time of Arrival: June 2
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Carboxy pyridostatin trifluoroacetate salt:

Carboxypyridostatin Get quote

3 Publications Citing Use of MCE Carboxy pyridostatin trifluoroacetate salt

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Carboxy pyridostatin trifluoroacetate salt (1-25 μM; 3 days) reduces the size of adult SVZ-derived neurospheres and the number of cells in neurospheres, and blocks proliferation and neurosphere fusion in adult SVZ-derived neurosphere cultures^[1].
Carboxy pyridostatin trifluoroacetate salt (10 μM; 24 h) hinders stress granule (SG) formation in U2OS cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Carboxy pyridostatin trifluoroacetate salt (10 mg/kg; i.p.; every 12 h; 3 injections) significantly reduces the number of PCNA-expressing cells in the adult SVZ and increases the number of OLIG2-expressing cells in the corpus callosum in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 mice (both sexes, 1-2 months old)^[1]
Dosage:	10 mg/kg (dissolved in phosphate-buffered saline)
Administration:	Intraperitoneal injection, every 12 h, 3 injections
Result:	Reduced the number of PCNA-expressing cells in the adult SVZ of mice, indicating a decrease in cell proliferation. Increased the number of OLIG2-expressing cells in the corpus callosum. Showed no increase in OLIG2-expression in the SVZ. Affected the differentiation of neural stem and progenitor cells in different brain regions.

Molecular Weight

820.73

Formula

C₃₇H₃₅F₃N₁₀O₉

CAS No.

2444713-88-4

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(O)CCN1N=NC(COC2=CC(C(NC3=NC4=CC=CC=C4C(OCCN)=C3)=O)=NC(C(NC5=NC6=CC=CC=C6C(OCCN)=C5)=O)=C2)=C1.FC(C(O)=O)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (121.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 60 mg/mL (73.11 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2184 mL	6.0921 mL	12.1843 mL
5 mM	0.2437 mL	1.2184 mL	2.4369 mL
10 mM	0.1218 mL	0.6092 mL	1.2184 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Purity & Documentation

Purity: 99.13%

Select Batch:

Data Sheet (278 KB) SDS (252 KB)

COA (255 KB) HNMR (113 KB) RP-HPLC (159 KB)

Handling Instructions (2659 KB)

References

[1]. Goldberg DC, et al. Manipulating Adult Neural Stem and Progenitor Cells with G-Quadruplex Ligands. ACS Chem Neurosci. 2020;11(10):1504-1518. [Content Brief]

[2]. Rocca R, et al. Molecular recognition of a carboxy pyridostatin toward G-quadruplex structures: Why does it prefer RNA? Chem Biol Drug Des. 2017 Nov;90(5):919-925. [Content Brief]

[3]. Turner M, et al. rG4detector, a novel RNA G-quadruplex predictor, uncovers their impact on stress granule formation. Nucleic Acids Res. 2022 Nov 11;50(20):11426-11441. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	1.2184 mL	6.0921 mL	12.1843 mL	30.4607 mL
	5 mM	0.2437 mL	1.2184 mL	2.4369 mL	6.0921 mL
	10 mM	0.1218 mL	0.6092 mL	1.2184 mL	3.0461 mL
	15 mM	0.0812 mL	0.4061 mL	0.8123 mL	2.0307 mL
	20 mM	0.0609 mL	0.3046 mL	0.6092 mL	1.5230 mL
	25 mM	0.0487 mL	0.2437 mL	0.4874 mL	1.2184 mL
	30 mM	0.0406 mL	0.2031 mL	0.4061 mL	1.0154 mL
	40 mM	0.0305 mL	0.1523 mL	0.3046 mL	0.7615 mL
	50 mM	0.0244 mL	0.1218 mL	0.2437 mL	0.6092 mL
	60 mM	0.0203 mL	0.1015 mL	0.2031 mL	0.5077 mL
DMSO	80 mM	0.0152 mL	0.0762 mL	0.1523 mL	0.3808 mL
DMSO	100 mM	0.0122 mL	0.0609 mL	0.1218 mL	0.3046 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.