1. Cell Cycle/DNA Damage
  2. G-quadruplex
  3. Carboxy pyridostatin trifluoroacetate salt

Carboxy pyridostatin trifluoroacetate salt is a G-quadruplex ligand. Carboxy pyridostatin trifluoroacetate salt has a highly molecular specificity to RNA on DNA G4s and reduces ATF-5 protein. Carboxy pyridostatin trifluoroacetate salt reduces cell proliferation and hinders stress granule (SG) formation.

For research use only. We do not sell to patients.

Carboxy pyridostatin trifluoroacetate salt Chemical Structure

Carboxy pyridostatin trifluoroacetate salt Chemical Structure

CAS No. : 2444713-88-4

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
USD 841 In-stock
Solution
10 mM * 1 mL in DMSO USD 885 In-stock
Solid
1 mg USD 280 In-stock
5 mg USD 580 In-stock
10 mg USD 980 In-stock
25 mg USD 1900 In-stock
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100 mg   Get quote  

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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Carboxy pyridostatin trifluoroacetate salt:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Carboxy pyridostatin trifluoroacetate salt is a G-quadruplex ligand. Carboxy pyridostatin trifluoroacetate salt has a highly molecular specificity to RNA on DNA G4s and reduces ATF-5 protein. Carboxy pyridostatin trifluoroacetate salt reduces cell proliferation and hinders stress granule (SG) formation[1][2][3].

In Vitro

Carboxy pyridostatin trifluoroacetate salt (1-25 μM; 3 days) reduces the size of adult SVZ-derived neurospheres and the number of cells in neurospheres, and blocks proliferation and neurosphere fusion in adult SVZ-derived neurosphere cultures[1].
Carboxy pyridostatin trifluoroacetate salt (10 μM; 24 h) hinders stress granule (SG) formation in U2OS cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Carboxy pyridostatin trifluoroacetate salt (10 mg/kg; i.p.; every 12 h; 3 injections) significantly reduces the number of PCNA-expressing cells in the adult SVZ and increases the number of OLIG2-expressing cells in the corpus callosum in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice (both sexes, 1-2 months old)[1]
Dosage: 10 mg/kg (dissolved in phosphate-buffered saline)
Administration: Intraperitoneal injection, every 12 h, 3 injections
Result: Reduced the number of PCNA-expressing cells in the adult SVZ of mice, indicating a decrease in cell proliferation.
Increased the number of OLIG2-expressing cells in the corpus callosum.
Showed no increase in OLIG2-expression in the SVZ.
Affected the differentiation of neural stem and progenitor cells in different brain regions.
Molecular Weight

820.73

Formula

C37H35F3N10O9

CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(O)CCN1N=NC(COC2=CC(C(NC3=NC4=CC=CC=C4C(OCCN)=C3)=O)=NC(C(NC5=NC6=CC=CC=C6C(OCCN)=C5)=O)=C2)=C1.FC(C(O)=O)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (121.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 60 mg/mL (73.11 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2184 mL 6.0921 mL 12.1843 mL
5 mM 0.2437 mL 1.2184 mL 2.4369 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Purity & Documentation

Purity: 99.13%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 1.2184 mL 6.0921 mL 12.1843 mL 30.4607 mL
5 mM 0.2437 mL 1.2184 mL 2.4369 mL 6.0921 mL
10 mM 0.1218 mL 0.6092 mL 1.2184 mL 3.0461 mL
15 mM 0.0812 mL 0.4061 mL 0.8123 mL 2.0307 mL
20 mM 0.0609 mL 0.3046 mL 0.6092 mL 1.5230 mL
25 mM 0.0487 mL 0.2437 mL 0.4874 mL 1.2184 mL
30 mM 0.0406 mL 0.2031 mL 0.4061 mL 1.0154 mL
40 mM 0.0305 mL 0.1523 mL 0.3046 mL 0.7615 mL
50 mM 0.0244 mL 0.1218 mL 0.2437 mL 0.6092 mL
60 mM 0.0203 mL 0.1015 mL 0.2031 mL 0.5077 mL
DMSO 80 mM 0.0152 mL 0.0762 mL 0.1523 mL 0.3808 mL
100 mM 0.0122 mL 0.0609 mL 0.1218 mL 0.3046 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Product Name:
Carboxy pyridostatin trifluoroacetate salt
Cat. No.:
HY-112680A
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