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Results for "

GCS

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Glucosylceramide Synthase (GCS) (14) Apoptosis (1) Fluorescent Dye (1) Interleukin Related (1) NF-κB (1)
By Research Areas:	Cancer (5) Inflammation/Immunology (2) Metabolic Disease (9) Neurological Disease (6)

Inhibitors & Agonists

Fluorescent Dye

Recombinant Proteins

Antibodies

Targets Recommended: Glucosylceramide Synthase (GCS)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-146564

R-HP210	NF-κB	Inflammation/Immunology
R-HP210 acts on the NF-κB mediated tethered transrepression function (IC₅₀=3.80 μM). R-HP210 represses the LPS-induced transcription of a variety of proinflammatory genes such as IL-1β, IL-6 and COX-2. R-HP210 does not induce the transactivation functions of Glucocorticoids (GCs) .

HY-129411

Sinbaglustat ACT-519276; OGT2378	Glucosylceramide Synthase (GCS)	Metabolic Disease
Sinbaglustat (OGT2378) is a dual inhibitor of glucosylceramide synthase (GCS) and non-lysosomal glucosyl ceramidase (GBA2). Sinbaglustat is an orally available N-alkyl iminosugar that crosses the blood-brain barrier. Sinbaglustat can be used for the research of central neurodegenerative diseases associated with lysosomal dysfunctions .

HY-144266

TP-060 Glucosylceramide synthase-IN-1	Glucosylceramide Synthase (GCS)	Neurological Disease Metabolic Disease
Glucosylceramide synthase-IN-1 (T-036) a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC₅₀s of 31 nM and 51 nM for human GCS and mouse GCS, respectively. Glucosylceramide synthase-IN-1 can be used for Gaucher's disease research .

HY-144267

Glucosylceramide synthase-IN-2	Glucosylceramide Synthase (GCS)	Neurological Disease Metabolic Disease
Glucosylceramide synthase-IN-2 (compound T-690) is a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC₅₀s of 15 nM and 190 nM for human GCS and mouse GCS, respectively.Glucosylceramide synthase-IN-2 exhibits noncompetitive type inhibition with C8-ceramide and UDP-glucose.Glucosylceramide synthase-IN-2 can be used for Gaucher's disease research .

HY-106392

Lucerastat NB-DGJ; N-(n-Butyl)deoxygalactonojirimycin	Glucosylceramide Synthase (GCS)	Metabolic Disease
Lucerastat, the galactose form of Miglustat, is an orally-available inhibitor of glucosylceramide synthase (GCS). Lucerastat has the potential for Fabry disease study .

HY-162726

GCS-11	Interleukin Related	Cancer
GCS-11 is a powerful natural killer T (NKT) cell agonist. It boosts the production of IFN-γ and IL-4, with a particular selectivity for IFN-γ. GCS-11 exhibits anticancer activity. GCS-11 has the potential for research into cancer immunotherapies or vaccine development as a promising adjuvant .

HY-162727

GCS-12	Others	Inflammation/Immunology Cancer
GCS-12 is a Th1/2-balanced sulfonamide glycolipid with improved interaction with CD1d. GCS-12 is an agonist for natural killer T (NKT) cell, that induces the secretion of cytokine IFN-γ and IL-4, and exhibits immunomodulatory and anti-tumor activities in mice .

HY-D1573

C6 NBD Phytoceramide	Fluorescent Dye	Others
C6 NBD Phytoceramide is a fluorescently labeled short-chain ceramide analog that can be recognized by mammalian GlcCer synthase (GCS) .

HY-116392E

D-threo-PDMP	Glucosylceramide Synthase (GCS)	Neurological Disease Metabolic Disease
D-threo-PDMP is a potent glucoceramide synthase (GCS) inhibitor, which reduces the glycosphingolipids on the cell surface by inhibiting glycosylation, reduces the total length of the axon plexus and the number of axon branch points, and inhibits neurite growth .

HY-144270

Glucosylceramide synthase-IN-3	Glucosylceramide Synthase (GCS)	Neurological Disease Metabolic Disease
Glucosylceramide synthase-IN-3 (compound BZ1) is a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC₅₀s of 16 nM for human GCS.Glucosylceramide synthase-IN-3 can be used for Gaucher's disease research .

HY-116392D

PDMP hydrochloride	Glucosylceramide Synthase (GCS) Apoptosis	Cancer
PDMP hydrochloride is a glucosylceramide synthase (GCS) inhibitor. PDMP hydrochloride induces apoptosis in K562/A02 cells. PDMP hydrochloride can be used in cancer (such as leukemia) research .

HY-116392B

DL-threo-PDMP hydrochloride	Glucosylceramide Synthase (GCS)	Cancer
DL-threo-PDMP hydrochloride is the hydrochloride form of DL-threo-PDMP that is a competitive glucosylceramide synthase (GCS) inhibitor. DL-threo-PDMP resensitizes refractory testicular germ cell tumors and epithelial ovarian cancer orthoxenografts to cisplatin in mice .

HY-116392A

(−)-L-threo-PDMP hydrochloride	Glucosylceramide Synthase (GCS)	Cancer
(−)-L-threo-PDMP hydrochloride is the hydrochloride form of (−)-L-threo-PDMP. L-threo-PDMP is a glucosylceramide synthase (GCS) inhibitor. L-threo-PDMP stimulates the proliferation of cultured aortic smooth muscle cells, and that increases the level of LacCer in B16 melanoma cells .

HY-16743C

Ibiglustat hydrochloride Venglustat hydrochloride; SAR402671 hydrochloride; GZ402671 hydrochloride	Glucosylceramide Synthase (GCS)	Metabolic Disease
Ibiglustat hydrochloride is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat hydrochloride can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease .

HY-16743

Ibiglustat 2 Publications Verification Venglustat; SAR402671; GZ402671	Glucosylceramide Synthase (GCS)	Metabolic Disease
Ibiglustat (Venglustat) is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease .

HY-16743B

Ibiglustat succinate 2 Publications Verification Venglustat succinate; SAR402671 succinate; GZ402671 succinate	Glucosylceramide Synthase (GCS)	Neurological Disease
Ibiglustat (Venglustat) succinate is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat succinate can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease .

HY-163131

Glucosylceramide synthase-IN-4	Glucosylceramide Synthase (GCS)	Neurological Disease
Glucosylceramide synthase-IN-4 (compound 12) is a potent glucosylceramide synthase (GCS) inhibitor, with an IC₅₀ of 6.8 nM. Glucosylceramide synthase-IN-4 shows excellent PK properties and stability in human hepatocytes. Glucosylceramide synthase-IN-4 has good CNS penetration and acceptable PXR selectivity .

HY-16743A

Ibiglustat (L-Malic acid) 2 Publications Verification Venglustat (L-Malic acid); SAR402671 (L-Malic acid); GZ402671 (L-Malic acid)	Glucosylceramide Synthase (GCS)	Metabolic Disease
Ibiglustat (Venglustat) L-Malic acid is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat L-Malic acid can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease .

Cat. No.	Product Name	Type

HY-D1573

C6 NBD Phytoceramide	Fluorescent Dyes/Probes
C6 NBD Phytoceramide is a fluorescently labeled short-chain ceramide analog that can be recognized by mammalian GlcCer synthase (GCS) .

Cat. No.	Compare	Product Name	Species	Source

HY-P71511

	*Gamma-GCS* Protein, E.coli (His-SUMO)** gshA; gsh-I; b2688; JW2663Glutamate--cysteine ligase; EC 6.3.2.2; Gamma-ECS; GCS; Gamma-glutamylcysteine synthetase	E.coli	E. coli
	Gamma-GCS protein is a key enzyme in sulfur metabolism and initiates glutathione synthesis by catalyzing the incorporation of L-cysteine and L-glutamic acid. This important molecule critical for cellular antioxidant defense is synthesized through a critical 1/2 step facilitated by γ-GCS. Gamma-GCS Protein, E.coli (His-SUMO) is the recombinant E. coli-derived Gamma-GCS protein, expressed by E. coli , with N-His, N-SUMO labeled tag.

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HY-P83192

	Guanylyl Cyclase alpha 1 Antibody (YA2937) GUCY1A3; GC-S-alpha-1; GUC1A3; GUCA3; GCS-alpha-3; GUCY1A1; GC-SA3; GCS-alpha-1; GUCSA3	WB	Human
	Guanylyl Cyclase alpha 1 Antibody (YA2937) is a biotin-conjugated non-conjugated IgG antibody, targeting Guanylyl Cyclase alpha 1, with a predicted molecular weight of 77 kDa (observed band size: 73 kDa). Guanylyl Cyclase alpha 1 Antibody (YA2937) can be used for WB experiment in human background.

HY-P82402

	Guanylyl Cyclase beta 1 Antibody (YA2147) GCbeta1; GCS beta 1; GCS beta 3; GUC1B3; GUCSB3; GUCY1B1; Gucy1b1; GUCY1B3; SGC	WB, IHC-P	Human, Mouse, Rat
	Guanylyl Cyclase beta 1 Antibody (YA2147) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2147), targeting Guanylyl Cyclase beta 1, with a predicted molecular weight of 71 kDa (observed band size: 71 kDa). Guanylyl Cyclase beta 1 Antibody (YA2147) can be used for WB, IHC-P experiment in human, mouse, rat background.

HY-P83153

	GCLC Antibody (YA2898) GCLC; GLCL; GLCLC; Glutamate--cysteine ligase catalytic subunit; GCS heavy chain; Gamma-ECS; Gamma-glutamylcysteine synthetase	WB	Human, Mouse, Rat
	GCLC Antibody (YA2898) is a biotin-conjugated non-conjugated IgG antibody, targeting GCLC, with a predicted molecular weight of 73 kDa (observed band size: 73 kDa). GCLC Antibody (YA2898) can be used for WB experiment in human, mouse, rat background.

HY-P81662

	GCLM Antibody (YA1407) GCLM; GLCLR; Glutamate--cysteine ligase regulatory subunit; GCS light chain; Gamma-ECS regulatory subunit; Gamma-glutamylcysteine synthetase regulatory subunit; Glutamate--cysteine ligase modifier subunit	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	GCLM Antibody (YA1407) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1407), targeting GCLM, with a predicted molecular weight of 31 kDa (observed band size: 31 kDa). GCLM Antibody (YA1407) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse, rat background.

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