Gamma-GCS Protein, E.coli (His-SUMO)

Gamma-GCS protein is a key enzyme in sulfur metabolism and initiates glutathione synthesis by catalyzing the incorporation of L-cysteine and L-glutamic acid. This important molecule critical for cellular antioxidant defense is synthesized through a critical 1/2 step facilitated by γ-GCS. Gamma-GCS Protein, E.coli (His-SUMO) is the recombinant E. coli-derived Gamma-GCS protein, expressed by E. coli , with N-His, N-SUMO labeled tag.

Gamma-GCS protein, a key enzyme in sulfur metabolism and glutathione biosynthesis, facilitates the critical step 1/2 of glutathione formation from L-cysteine and L-glutamate. As part of this enzymatic process, gamma-GCS catalyzes the incorporation of L-cysteine and L-glutamate, initiating the synthesis of glutathione. This molecule, essential for cellular antioxidant defense and detoxification, plays a crucial role in maintaining redox homeostasis within the cell. By orchestrating the initial steps of glutathione biosynthesis, gamma-GCS contributes to the cellular mechanisms that protect against oxidative stress and support overall cellular health.

E.coli

E. coli

N-His;N-SUMO

P0A6W9 (M1-A518)

944881  [NCBI]

MIPDVSQALAWLEKHPQALKGIQRGLERETLRVNADGTLATTGHPEALGSALTHKWITTDFAEALLEFITPVDGDIEHMLTFMRDLHRYTARNMGDERMWPLSMPCYIAEGQDIELAQYGTSNTGRFKTLYREGLKNRYGALMQTISGVHYNFSLPMAFWQAKCGDISGADAKEKISAGYFRVIRNYYRFGWVIPYLFGASPAICSSFLQGKPTSLPFEKTECGMYYLPYATSLRLSDLGYTNKSQSNLGITFNDLYEYVAGLKQAIKTPSEEYAKIGIEKDGKRLQINSNVLQIENELYAPIRPKRVTRSGESPSDALLRGGIEYIEVRSLDINPFSPIGVDEQQVRFLDLFMVWCALADAPEMSSSELACTRVNWNRVILEGRKPGLTLGIGCETAQFPLPQVGKDLFRDLKRVAQTLDSINGGEAYQKVCDELVACFDNPDLTFSARILRSMIDTGIGGTGKAFAEAYRNLLREEPLEILREEDFVAEREASERRQQEMEAADTEPFAVWLEKHA

Approximately 74.3 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.