2. Neuronal Signaling
  3. Glucosylceramide Synthase (GCS)
  4. Glucosylceramide synthase-IN-4

Glucosylceramide synthase-IN-4 (compound 12) is a potent glucosylceramide synthase (GCS) inhibitor, with an IC50 of 6.8 nM. Glucosylceramide synthase-IN-4 shows excellent PK properties and stability in human hepatocytes. Glucosylceramide synthase-IN-4 has good CNS penetration and acceptable PXR selectivity.

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Glucosylceramide synthase-IN-4 Chemical Structure

Glucosylceramide synthase-IN-4 Chemical Structure

CAS No. : 2776965-41-2

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Glucosylceramide synthase-IN-4 Related Antibodies

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Description

Glucosylceramide synthase-IN-4 (compound 12) is a potent glucosylceramide synthase (GCS) inhibitor, with an IC50 of 6.8 nM. Glucosylceramide synthase-IN-4 shows excellent PK properties and stability in human hepatocytes. Glucosylceramide synthase-IN-4 has good CNS penetration and acceptable PXR selectivity[1].

Molecular Weight

467.39

Formula

C22H18F5N3O3
CAS No.
SMILES

CC1=NN=C(C2=CC=C(C=C2)C3=C4C(N(CC4=CC(F)=C3F)[C@H](C(F)(F)F)C(C)(O)C)=O)O1
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Room temperature in continental US; may vary elsewhere.
Storage

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Purity & Documentation
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Glucosylceramide synthase-IN-4 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glucosylceramide synthase-IN-42776965-41-2Glucosylceramide Synthase (GCS)Inhibitorinhibitorinhibit

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