2. Neuronal Signaling
  3. Glucosylceramide Synthase (GCS)
  4. D-threo-PDMP

D-threo-PDMP is a potent glucoceramide synthase (GCS) inhibitor, which reduces the glycosphingolipids on the cell surface by inhibiting glycosylation, reduces the total length of the axon plexus and the number of axon branch points, and inhibits neurite growth.

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D-threo-PDMP Chemical Structure

D-threo-PDMP Chemical Structure

CAS No. : 109836-82-0

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D-threo-PDMP Related Antibodies

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Description

D-threo-PDMP is a potent glucoceramide synthase (GCS) inhibitor, which reduces the glycosphingolipids on the cell surface by inhibiting glycosylation, reduces the total length of the axon plexus and the number of axon branch points, and inhibits neurite growth[1][2].

In Vitro

D-threo-PDMP pretreatment of hepatocytes eliminates the stimulation of glycosphingolipid levels by TNF-α (280 ng/mL) and enhances ceramide production[1].
D-threo-PDMP(20 μM, 48 h) significantly stimulates the proliferation of tethered glomerular mesangial cells (GMC), and these increases are significantly attenuated in a dose-dependent manner by exogenous ganglioside mixtures (0.1-0.2 mg/ml) or GM3 (20-100 μM). It also induced a significant decrease in ganglioside expression[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

D-threo-PDMP Related Antibodies
Molecular Weight

390.56

Formula

C23H38N2O3
CAS No.
SMILES

CCCCCCCCCC(N[C@H](CN1CCOCC1)[C@H](O)C2=CC=CC=C2)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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D-threo-PDMP Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D-threo-PDMP109836-82-0Glucosylceramide Synthase (GCS)GCSglycosylationglycosphingolipidsneurite growthInhibitorinhibitorinhibit

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