PDMP hydrochloride

Cat. No.: HY-116392D Purity: ≥99.0%: Data Sheet
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PDMP hydrochloride is a glucosylceramide synthase (GCS) inhibitor. PDMP hydrochloride induces apoptosis in K562/A02 cells. PDMP hydrochloride can be used in cancer (such as leukemia) research.

For research use only. We do not sell to patients.

PDMP hydrochloride Chemical Structure

CAS No. : 73257-80-4

Size	Price	Stock	Quantity
5 mg	USD 83	In-stock	Estimated Time of Arrival: April 15
10 mg	USD 132	In-stock	Estimated Time of Arrival: April 15
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of PDMP hydrochloride:

(−)-L-threo-PDMP hydrochloride Get quote
DL-threo-PDMP hydrochloride Get quote
D-threo-PDMP Get quote
D-threo-PDMP hydrochloride Get quote
D,L-erythro-PDMP Get quote
D,L-erythro-PDMP hydrochloride Get quote

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Biological Activity
Purity & Documentation
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Description	PDMP hydrochloride is a glucosylceramide synthase (GCS) inhibitor. PDMP hydrochloride induces apoptosis in K562/A02 cells. PDMP hydrochloride can be used in cancer (such as leukemia) research^[1]^[2].
Formula	C₂₃H₃₉ClN₂O₃
CAS No.	73257-80-4
Appearance	Solid
Color	White to off-white
SMILES	CCCCCCCCCC(NC(CN1CCOCC1)C(C2=CC=CC=C2)O)=O.[x].Cl
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility	In Vitro: DMSO : 30 mg/mL (Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Molarity Calculator Dilution Calculator Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Mass = Concentration × Volume × Molecular Weight * Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final) This equation is commonly abbreviated as: C₁V₁ = C₂V₂ Concentration _(start) C1 × Volume _(start) V1 = Concentration _(final) C2 × Volume _(final) V2 In Vivo Dissolution Calculator Please enter the basic information of animal experiments: Dosage mg/kg Animal weight (per animal) g Dosing volume (per animal) μL Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Purity & Documentation	Purity: ≥99.0% Select Batch: Data Sheet (265 KB) SDS (393 KB) COA (244 KB) Handling Instructions (2659 KB)
References	[1]. Casson L, et al. Inhibition of ceramide metabolism sensitizes human leukemia cells to inhibition of BCL2-like proteins. PLoS One. 2013;8(1):e54525. [Content Brief] [2]. Yin L, et al. Effect of PDMP, a glucosylceramide synthase inhibitor, on reversion of daunorubicin resistance in human leukemia cell line K562/A02. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010 Feb;18(1):79-84. [Content Brief]