2. Neuronal Signaling
  3. Glucosylceramide Synthase (GCS)
  4. DL-threo-PDMP hydrochloride

DL-threo-PDMP hydrochloride is the hydrochloride form of DL-threo-PDMP that is a competitive glucosylceramide synthase (GCS) inhibitor. DL-threo-PDMP resensitizes refractory testicular germ cell tumors and epithelial ovarian cancer orthoxenografts to cisplatin in mice.

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DL-threo-PDMP hydrochloride Chemical Structure

DL-threo-PDMP hydrochloride Chemical Structure

CAS No. : 80938-69-8

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10 mg USD 155 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

DL-threo-PDMP hydrochloride is the hydrochloride form of DL-threo-PDMP that is a competitive glucosylceramide synthase (GCS) inhibitor. DL-threo-PDMP resensitizes refractory testicular germ cell tumors and epithelial ovarian cancer orthoxenografts to cisplatin in mice[1].

Molecular Weight

427.02

Formula

C23H39ClN2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H](C1=CC=CC=C1)[C@H](NC(CCCCCCCCC)=O)CN2CCOCC2.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 30 mg/mL (70.25 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3418 mL 11.7091 mL 23.4181 mL
5 mM 0.4684 mL 2.3418 mL 4.6836 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation

Purity: 98.4%

SDS (252 KB)

COA (245 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3418 mL 11.7091 mL 23.4181 mL 58.5453 mL
5 mM 0.4684 mL 2.3418 mL 4.6836 mL 11.7091 mL
10 mM 0.2342 mL 1.1709 mL 2.3418 mL 5.8545 mL
15 mM 0.1561 mL 0.7806 mL 1.5612 mL 3.9030 mL
20 mM 0.1171 mL 0.5855 mL 1.1709 mL 2.9273 mL
25 mM 0.0937 mL 0.4684 mL 0.9367 mL 2.3418 mL
30 mM 0.0781 mL 0.3903 mL 0.7806 mL 1.9515 mL
40 mM 0.0585 mL 0.2927 mL 0.5855 mL 1.4636 mL
50 mM 0.0468 mL 0.2342 mL 0.4684 mL 1.1709 mL
60 mM 0.0390 mL 0.1952 mL 0.3903 mL 0.9758 mL
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DL-threo-PDMP hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DL-threo-PDMP80938-69-8Glucosylceramide Synthase (GCS)HydrochloridecancerTGCTEOCcisplatinInhibitorinhibitorinhibit

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