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H23

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Apoptosis (3) ATTECs (1) Bcl-2 Family (1) Biochemical Assay Reagents (3) Deubiquitinase (2) Discoidin Domain Receptor (1) Microtubule/Tubulin (1) PERK (1) PROTACs (2) Ras (2) Src (1) Wee1 (1)
By Research Areas:	Cancer (11) Metabolic Disease (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-131177

yGsy2p-IN-H23	Others	Metabolic Disease
yGsy2p-IN-H23 is a potent and first-in-class inhibitor for yeast glycogen synthase 2 (yGsy2p) with an IC₅₀ of 875 µM for human glycogen synthase 1 (hGYS1). yGsy2p-IN-H23 bounds within the uridine diphosphate glucose binding pocket of yGsy2p. yGsy2p-IN-H23 is used for the research of glycogen storage diseases (GSDs) .

HY-123298

Chrysotoxine	Src Akt Apoptosis	Cancer
Chrysotoxine is a dual inhibitor of Src/Akt. Chrysotoxine suppresses cancer stem cells (CSCs) phenotypes by down-regulating Src/Akt signaling. Chrysotoxine reduces cell viability and increases apoptosis level in H460 and H23 cells instead of non-tumor cell lines. Chrysotoxine shows rapid excretion and low bioavailability in rats. Chrysotoxine is used in cancer research .

HY-131062

yGsy2p-IN-1	Others	Metabolic Disease
yGsy2p-IN-1 is a potent inhibitor for yeast glycogen synthase 2 (yGsy2p). yGsy2p-IN-1 is a competitive human glycogen synthase 1 (hGYS1) inhibitor with an IC₅₀ of 2.75 µM and a K_i of 1.31 µM for wild-type hGYS1. yGsy2p-IN-H23 a pyrazole inhibitor, is used for glycogen storage diseases (GSDs) .

HY-164389

SML-10-70-1	Ras	Cancer
SML-10-70-1 is a ligand for RAS, which covalently modifies the K-Ras G12C mutant protein, and inhibits the phosphorylation of ERK and Akt. SML-10-70-1 inhibits the proliferation of cancer cells H23, H358 and A549 with IC₅₀ of 26.6-47.6 μM .

HY-146061

KRAS G12C inhibitor 48	Ras	Cancer
KRAS G12C inhibitor 48 (compound 6e) is a potent KRAS G12C inhibitor with an IC₅₀ of 639.91 nM. KRAS G12C inhibitor 48 (0-50 µM) shows anti-proliferative activity with IC₅₀s of 0.796, 6.33, 16.14 µM for H358, H23, A549 cells, respectively .

HY-162540

LLC355	ATTECs Discoidin Domain Receptor	Cancer
LLC355 is a discoidin domain receptor 1 (DDR1) ATTEC degrader. LLC355 efficiently degrades DDR1 protein with a DC₅₀ value of 150.8 nM in non-small cell lung cancer NCI-H23 cells. LLC355 induces DDR1 degradation via lysosome-mediated autophagy. LLC355 potently inhibits cancer cell tumorigenicity, migration, and invasion .

HY-169096

DPP-21	Microtubule/Tubulin Apoptosis	Cancer
DPP-21 is an inhibitor of tubulin polymerization (IC₅₀: 2.4 μM). DPP-21 shows anti-proliferative activity against cancer cell lines, with IC₅₀s of 0.38 nM (HCT116), 11.69 nM (B16), 5.37 nM (HeLa), 9.53 nM (MCF7), 8.94 nM (H23) and 9.37 nM (HepG2) respectively. DPP-21 arrests the cell cycle in the G2/M phase of mitosis, subsequently inducing tumor cell apoptosis (decreases Bcl-2 but upregulates the pro-apoptotic protein Bax) .

HY-W441531

2,3,7,8,12,13,17,18-Octaethyl-21H,23H-porphine manganese(III) chloride	Others
2,3,7,8,12,13,17,18-Octaethyl-21H,23H-porphine manganese(III) chloride is a transition metal compound with excellent catalytic activity. 2,3,7,8,12,13,17,18-Octaethyl-21H,23H-porphine manganese(III) chloride is widely used in photocatalytic reactions to improve reaction efficiency. 2,3,7,8,12,13,17,18-Octaethyl-21H,23H-porphine manganese(III) chloride is also used in the preparation of optical materials, giving the materials excellent light absorption properties. The biological activity of 2,3,7,8,12,13,17,18-Octaethyl-21H,23H-porphine manganese(III) chloride has gradually attracted attention in the research of the medical field.

HY-W112277

5,10,15,20-Tetrakis(4-methoxyphenyl)-21H,23H-porphine iron(III) chloride	Others	Others
5,10,15,20-Tetrakis(4-methoxyphenyl)-21H,23H-porphine iron(III) chloride is a type of metalloporphyrin complex that features iron(III) at its core.

HY-W392514

Nickel octaethylporphyrin	Others	Others
Nickel octaethylporphyrin can be synthesized by the metalation of 2,3,7,8,12,13,17,18-Octaethyl-21H,23H-porphine with nickel (II).

HY-W073013

Cobalt(II) TPP	Biochemical Assay Reagents	Others
5,10,15,20-Tetraphenyl-21H,23H-porphine cobalt(II), commonly known as CoTPP or cobalt porphyrin, is a coordination compound. 5,10,15,20-Tetraphenyl-21H,23H-porphine cobalt(II) is widely used in various fields such as catalysis, sensing, and organic electronics because of its unique electronic and optical properties. An efficient catalyst for reactions including oxidation, reduction, and CH bond activation, moreover, it has been used as a fluorescent probe for detecting oxygen content in biological systems and as an active material in organic solar cells.

HY-125877

PROTAC Mcl1 degrader-1 1 Publications Verification	PROTACs Bcl-2 Family	Cancer
PROTAC Mcl1 degrader-1 (compound C3), a proteolysis targeting chimera (PROTAC) based on Cereblon ligand, is a potently and selectively Mcl-1 (Bcl-2 family member) inhibitor with an IC₅₀ of 0.78 μM. PROTAC Mcl1 degrader-1 inhibits Bcl-2 with an IC₅₀ of 0.54 μM .

HY-144323

YF135	PROTACs PERK	Cancer
YF135 is an efficient and reversible-covalent KRAS ^G12C PROTAC. YF135 is designed and synthesized by tethering KRAS G12C inhibitor 48 (compound 6d) as the ligand, and basing on the scaffold of MRTX849 linkage VHL ligand. YF135 significantly induces the degradation of KRAS ^G12C in a reversible manner and decreases phospho-ERK level through the E3 ligase VHL mediated proteasome pathway .

HY-151563

OTUB1/USP8-IN-1	Deubiquitinase	Cancer
OTUB1/USP8-IN-1 is a potent dual OTUB1/USP8 inhibitor with IC₅₀ values of 0.17 and 0.28 nM for OTUB1 and USP8, respectively. OTUB1/USP8-IN-1 can be used in research of cancer .

HY-W112090

Palladium meso-tetra(pentafluorophenyl)porphyrin PdTFPP; 5,10,15,20-Tetrakis(pentafluorophenyl)-21H,23H-porphine palladium(II)	Others	Others
Palladium meso-tetra(pentafluorophenyl)porphyrin (PdTFPP) is a phosphorescent dye, derived from palladium(II), that serves as an effective singlet oxygen sensitizer due to its fluorine atom content, offering excellent photostability and resistance to oxidation.

HY-W035133

5,10,15,20-Tetrakis(p-tolyl)porphyrin 5,10,15,20-Tetra-p-tolyl-21H,23H-porphine	Biochemical Assay Reagents	Others
5,10,15,20-Tetrakis(p-tolyl)porphyrin (TTP) is an organic compound belonging to the class of porphyrins, a cyclic molecule composed of four pyrrole rings linked together. TTP is a synthetic porphyrin commonly used as a sensitizer for dye-sensitized solar cells and a catalyst for organic reactions. Due to its unique structure, TTP has a series of interesting properties, including at specific wavelengths and its potential as a catalyst for various chemical reactions. In dye-sensitized solar cells, TTPs help convert sunlight into electricity by absorbing photons and transferring electrons to the semiconductor layer of the device. In organic chemistry, TTP is often used as a catalyst for various organic compounds in reactions such as oxidation and reduction. Its ability to selectively bind certain substrates makes it a useful tool for synthesizing complex molecules and studying their properties.

HY-W035140

5,10,15,20-Tetrakis(4-hydroxyphenyl)porphyrin 5,10,15,20-Tetrakis(4-hydroxyphenyl)-21H,23H-porphine	Biochemical Assay Reagents	Others
5,10,15,20-Tetrakis(4-hydroxyphenyl)porphyrin is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-132295

Azenosertib 1 Publications Verification ZN-c3	Wee1	Cancer
Azenosertib (ZN-c3) is a selective, orally active inhibitor for Wee1 inhibitor (IC₅₀=3.9 nM). Azenosertib exhibits antitumor activity .

HY-151563A

OTUB1/USP8-IN-1 TFA	Deubiquitinase	Cancer
OTUB1/USP8-IN-1 TFA is the TFA salt form of OTUB1/USP8-IN-1 (HY-151563). OTUB1/USP8-IN-1 TFA is a dual inhibitor for OTUB1/USP8, IC₅₀ for OTUB1 and USP8 is 0.17 and 0.28 nM, respectively. OTUB1/USP8-IN-1 TFA inhibits proliferation of NSCLC cells. OTUB1/USP8-IN-1 TFA exhibits good pharmacokinetic characters in ICR mouse, and exhibits antitumor activity in H1975 xenograft mouse model .

HY-147328

LCS3	Apoptosis	Cancer
LCS3 is a reversible and uncompetitive glutathione disulfide reductase (GSR) and thioredoxin reductase 1 (TXNRD1) inhibitor (IC₅₀=3.3 µM and 3.8 µM, respectively). LCS3 shows anti-tumor activity, and induces apoptosis. LCS3 can be used in lung adenocarcinoma (LUAD) research .

Cat. No.	Product Name	Type

HY-W073013

Cobalt(II) TPP	Biochemical Assay Reagents
5,10,15,20-Tetraphenyl-21H,23H-porphine cobalt(II), commonly known as CoTPP or cobalt porphyrin, is a coordination compound. 5,10,15,20-Tetraphenyl-21H,23H-porphine cobalt(II) is widely used in various fields such as catalysis, sensing, and organic electronics because of its unique electronic and optical properties. An efficient catalyst for reactions including oxidation, reduction, and CH bond activation, moreover, it has been used as a fluorescent probe for detecting oxygen content in biological systems and as an active material in organic solar cells.

Cobalt(II) TPP

Biochemical Assay Reagents

5,10,15,20-Tetraphenyl-21H,23H-porphine cobalt(II), commonly known as CoTPP or cobalt porphyrin, is a coordination compound. 5,10,15,20-Tetraphenyl-21H,23H-porphine cobalt(II) is widely used in various fields such as catalysis, sensing, and organic electronics because of its unique electronic and optical properties. An efficient catalyst for reactions including oxidation, reduction, and CH bond activation, moreover, it has been used as a fluorescent probe for detecting oxygen content in biological systems and as an active material in organic solar cells.

HY-W035140

5,10,15,20-Tetrakis(4-hydroxyphenyl)porphyrin 5,10,15,20-Tetrakis(4-hydroxyphenyl)-21H,23H-porphine	Biochemical Assay Reagents
5,10,15,20-Tetrakis(4-hydroxyphenyl)porphyrin is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W035133

5,10,15,20-Tetrakis(p-tolyl)porphyrin 5,10,15,20-Tetra-p-tolyl-21H,23H-porphine	Biochemical Assay Reagents
5,10,15,20-Tetrakis(p-tolyl)porphyrin (TTP) is an organic compound belonging to the class of porphyrins, a cyclic molecule composed of four pyrrole rings linked together. TTP is a synthetic porphyrin commonly used as a sensitizer for dye-sensitized solar cells and a catalyst for organic reactions. Due to its unique structure, TTP has a series of interesting properties, including at specific wavelengths and its potential as a catalyst for various chemical reactions. In dye-sensitized solar cells, TTPs help convert sunlight into electricity by absorbing photons and transferring electrons to the semiconductor layer of the device. In organic chemistry, TTP is often used as a catalyst for various organic compounds in reactions such as oxidation and reduction. Its ability to selectively bind certain substrates makes it a useful tool for synthesizing complex molecules and studying their properties.

5,10,15,20-Tetrakis(p-tolyl)porphyrin

5,10,15,20-Tetra-p-tolyl-21H,23H-porphine

Biochemical Assay Reagents

5,10,15,20-Tetrakis(p-tolyl)porphyrin (TTP) is an organic compound belonging to the class of porphyrins, a cyclic molecule composed of four pyrrole rings linked together. TTP is a synthetic porphyrin commonly used as a sensitizer for dye-sensitized solar cells and a catalyst for organic reactions. Due to its unique structure, TTP has a series of interesting properties, including at specific wavelengths and its potential as a catalyst for various chemical reactions. In dye-sensitized solar cells, TTPs help convert sunlight into electricity by absorbing photons and transferring electrons to the semiconductor layer of the device. In organic chemistry, TTP is often used as a catalyst for various organic compounds in reactions such as oxidation and reduction. Its ability to selectively bind certain substrates makes it a useful tool for synthesizing complex molecules and studying their properties.

Chrysotoxine	Structural Classification Monophenols Orchidaceae Source classification Phenols Plants Dendrobium pulchellum Roxb. et Lindl. :Lindl.	Src Akt Apoptosis
Chrysotoxine is a dual inhibitor of Src/Akt. Chrysotoxine suppresses cancer stem cells (CSCs) phenotypes by down-regulating Src/Akt signaling. Chrysotoxine reduces cell viability and increases apoptosis level in H460 and H23 cells instead of non-tumor cell lines. Chrysotoxine shows rapid excretion and low bioavailability in rats. Chrysotoxine is used in cancer research .

Species:	Human (8)
Tag:	His (3) Avi (2) Fc (5)
Source:	HEK293 (8)

Cat. No.	Compare	Product Name	Species	Source

HY-P78774

	Mucin-1/MUC1 Protein, Human (HEK293, mFc) Mucin 1; MUC1; CD227; EMA; H23AG; KL-6; MAM6; MUC-1; SEC; MUC-1; X; MUC1; ZD; PEM; PEMT; PUM; CA15-3; Episialin	Human	HEK293
	Mucin-1/MUC1 protein and its α subunit have dual functions of adhesion and anti-adhesion proteins, forming a protective layer on epithelial cells. At the same time, the β subunit and its C-terminal domain participate in cell signaling through phosphorylation and protein-protein interactions. Mucin-1/MUC1 Protein, Human (HEK293, mFc) is the recombinant human-derived Mucin-1/MUC1 protein, expressed by HEK293 , with C-mFc labeled tag.

HY-P78833

	Mucin-1/MUC1 Protein, Human (Biotinylated, HEK293, His-Avi) Mucin 1; MUC1; CD227; EMA; H23AG; KL-6; MAM6; MUC-1; SEC; MUC-1; X; MUC1; ZD; PEM; PEMT; PUM; CA15-3; Episialin	Human	HEK293
	Mucin-1/MUC1 protein and its α subunit have dual functions of adhesion and anti-adhesion proteins, forming a protective layer on epithelial cells. At the same time, the β subunit and its C-terminal domain participate in cell signaling through phosphorylation and protein-protein interactions. Mucin-1/MUC1 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived Mucin-1/MUC1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P78733

	Mucin-1/MUC1 Protein, Human (269a.a, HEK293, His) Mucin 1; MUC1; CD227; EMA; H23AG; KL-6; MAM6; MUC-1; SEC; MUC-1; X; MUC1; ZD; PEM; PEMT; PUM; CA15-3; Episialin	Human	HEK293
	Mucin-1/MUC1 protein and its α subunit have dual functions of adhesion and anti-adhesion proteins, forming a protective layer on epithelial cells. At the same time, the β subunit and its C-terminal domain participate in cell signaling through phosphorylation and protein-protein interactions. Mucin-1/MUC1 Protein, Human (269a.a, HEK293, His) is the recombinant human-derived Mucin-1/MUC1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P78734

	Mucin-1/MUC1 Protein, Human (120a.a, HEK293, His) Mucin 1; MUC1; CD227; EMA; H23AG; KL-6; MAM6; MUC-1; SEC; MUC-1; X; MUC1; ZD; PEM; PEMT; PUM; CA15-3; Episialin	Human	HEK293
	Mucin-1/MUC1 protein and its α subunit have dual functions of adhesion and anti-adhesion proteins, forming a protective layer on epithelial cells. At the same time, the β subunit and its C-terminal domain participate in cell signaling through phosphorylation and protein-protein interactions. Mucin-1/MUC1 Protein, Human (120a.a, HEK293, His) is the recombinant human-derived Mucin-1/MUC1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P78740

	Mucin-1/MUC1 Protein, Human (357a.a, HEK293, Fc) Mucin 1; MUC1; CD227; EMA; H23AG; KL-6; MAM6; MUC-1; SEC; MUC-1; X; MUC1; ZD; PEM; PEMT; PUM; CA15-3; Episialin	Human	HEK293
	Mucin-1/MUC1 protein and its α subunit have dual functions of adhesion and anti-adhesion proteins, forming a protective layer on epithelial cells. At the same time, the β subunit and its C-terminal domain participate in cell signaling through phosphorylation and protein-protein interactions. Mucin-1/MUC1 Protein, Human (357a.a, HEK293, Fc) is the recombinant human-derived Mucin-1/MUC1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Mucin-1/MUC1 Protein, Human (357a.a, HEK293, Fc) is 357 a.a., with molecular weight of ~70 kDa.

HY-P70301

	Mucin-1/MUC1 Protein, Human (HEK293, Fc) rHuMucin-1, Fc; Mucin-1; MUC-1; Breast carcinoma-associated antigen DF3; Cancer antigen 15-3; CA 15-3; Carcinoma-associated mucin; Episialin; H23AG; Krebs von den Lungen-6; KL-6; PEMT; Peanut-reactive urinary mucin; PUM; Polymorphic epithelial mucin; PEM; Tumor-associated epithelial membrane antigen; EMA; Tumor-associated mucin; CD227; MUC1	Human	HEK293
	Mucin-1/MUC1 protein and its α subunit have dual functions of adhesion and anti-adhesion proteins, forming a protective layer on epithelial cells. At the same time, the β subunit and its C-terminal domain participate in cell signaling through phosphorylation and protein-protein interactions. Mucin-1/MUC1 Protein, Human (HEK293, Fc) is the recombinant human-derived Mucin-1/MUC1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Mucin-1/MUC1 Protein, Human (HEK293, Fc) is 145 a.a., with molecular weight of 45-88 kDa.

HY-P700795

	Mucin-1/MUC1 Isoform Y Protein, Human (HEK293, Fc) MUC1/Y; MUC1; MUC-1; Mucin-1; Mucin1; CA 15-3; Episialin; H23AG; KL-6; PEMT; PUM; PEM; EMA; CD227	Human	HEK293
	Mucin-1/MUC1 protein and its α subunit have dual functions of adhesion and anti-adhesion proteins, forming a protective layer on epithelial cells. At the same time, the β subunit and its C-terminal domain participate in cell signaling through phosphorylation and protein-protein interactions. Mucin-1/MUC1 Isoform Y Protein, Human (HEK293, Fc) is the recombinant human-derived Mucin-1/MUC1 Isoform Y protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Mucin-1/MUC1 Isoform Y Protein, Human (HEK293, Fc) is 135 a.a., with molecular weight of 55-65 kDa.

HY-P72399

	Mucin-1/MUC1 Protein, Human (Biotinylated, HEK293, Fc-Avi) MUC-1; CA 15-3; Carcinoma-associated mucin; Episialin; H23AG; Krebs von den Lungen-6; KL-6; PEMT; PUM; PEM; EMA; CD227; MUC1	Human	HEK293
	Mucin-1/MUC1 protein and its α subunit have dual functions of adhesion and anti-adhesion proteins, forming a protective layer on epithelial cells. At the same time, the β subunit and its C-terminal domain participate in cell signaling through phosphorylation and protein-protein interactions. Mucin-1/MUC1 Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived Mucin-1/MUC1 protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag. The total length of Mucin-1/MUC1 Protein, Human (Biotinylated, HEK293, Fc-Avi) is 144 a.a., with molecular weight of 55-75 kDa.

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HY-P83341

	Mucin 1 Antibody (YA3086) MUC1; PUM; Mucin-1; MUC-1; Breast carcinoma-associated antigen DF3; Carcinoma-associated mucin; Episialin; H23AG; Krebs von den Lungen-6; KL-6; PEMT; Peanut-reactive urinary mucin; PUM; Polymorphic epithelial mucin; PEM; Tumor-associated ep	WB, IHC-P, ICC/IF, IP, FC	Human
	Mucin 1 Antibody (YA3086) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3086), targeting Mucin 1, with a predicted molecular weight of 122 kDa (observed band size: 18-25 kDa). Mucin 1 Antibody (YA3086) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human background.

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H23

Inhibitors & Agonists

Biochemical Assay Reagents

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Recombinant Proteins

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