2. PROTAC Autophagy Protein Tyrosine Kinase/RTK
  3. ATTECs Discoidin Domain Receptor
  4. LLC355

LLC355 is a discoidin domain receptor 1 (DDR1) ATTEC degrader. LLC355 efficiently degrades DDR1 protein with a DC50 value of 150.8 nM in non-small cell lung cancer NCI-H23 cells. LLC355 induces DDR1 degradation via lysosome-mediated autophagy. LLC355 potently inhibits cancer cell tumorigenicity, migration, and invasion.

For research use only. We do not sell to patients.

LLC355 Chemical Structure

LLC355 Chemical Structure

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LLC355 Related Antibodies

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DDR1 DDR2

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Description

LLC355 is a discoidin domain receptor 1 (DDR1) ATTEC degrader. LLC355 efficiently degrades DDR1 protein with a DC50 value of 150.8 nM in non-small cell lung cancer NCI-H23 cells. LLC355 induces DDR1 degradation via lysosome-mediated autophagy. LLC355 potently inhibits cancer cell tumorigenicity, migration, and invasion[1].

Molecular Weight

1133.69

Formula

C63H64ClF3N10O5
SMILES

O=C1C2=CC=C(Cl)C=C2N=C([C@H](N(C(C3=CC=C(C)C=C3)=O)CCCNC(COCCN4CCN(CC5=CC(C(F)(F)F)=CC(NC(C6=CC(C#CC(C=N7)=CN8C7=CC=N8)=C(CC)C=C6)=O)=C5)CC4)=O)C(C)C)N1CC9=CC=CC=C9
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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LLC355 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LLC355LLC 355LLC-355ATTECsDiscoidin Domain ReceptorAutophagosome-tethering compoundsNCI-H23non-small cell lung cancerlysosome-mediated autophagytumorigenicitymigrationinvasionInhibitorinhibitorinhibit

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