OTUB1/USP8-IN-1 TFA

Cat. No.: HY-151563A Purity: 99.56%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

OTUB1/USP8-IN-1 TFA is the TFA salt form of OTUB1/USP8-IN-1 (HY-151563). OTUB1/USP8-IN-1 TFA is a dual inhibitor for OTUB1/USP8, IC₅₀ for OTUB1 and USP8 is 0.17 and 0.28 nM, respectively. OTUB1/USP8-IN-1 TFA inhibits proliferation of NSCLC cells. OTUB1/USP8-IN-1 TFA exhibits good pharmacokinetic characters in ICR mouse, and exhibits antitumor activity in H1975 xenograft mouse model.

For research use only. We do not sell to patients.

OTUB1/USP8-IN-1 TFA Chemical Structure

Size	Price	Stock	Quantity
5 mg	USD 300	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Other Forms of OTUB1/USP8-IN-1 TFA:

OTUB1/USP8-IN-1 Get quote

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USP1 USP2 USP7 USP8 USP30 UCHL1

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

USP8

0.28 nM (IC₅₀)

Molecular Weight

540.85

Formula

C₂₄H₁₇ClF₄N₂O₆

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=C2OC(C3=C(F)C=CC(O[C@H]4CN(C)CC4)=C3Cl)=N1)C5=C(C=CC=C5)C2=O.OC(C(F)(F)F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (184.89 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8489 mL	9.2447 mL	18.4894 mL
5 mM	0.3698 mL	1.8489 mL	3.6979 mL
10 mM	0.1849 mL	0.9245 mL	1.8489 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.56%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (253 KB) HNMR (282 KB) RP-HPLC (246 KB) LCMS (158 KB)

Handling Instructions (2659 KB)

References

[1]. Tan L, et, al. Discovery of Potent OTUB1/USP8 Dual Inhibitors Targeting Proteostasis in Non-Small-Cell Lung Cancer. J Med Chem. 2022 Oct 11. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8489 mL	9.2447 mL	18.4894 mL	46.2235 mL
	5 mM	0.3698 mL	1.8489 mL	3.6979 mL	9.2447 mL
	10 mM	0.1849 mL	0.9245 mL	1.8489 mL	4.6224 mL
	15 mM	0.1233 mL	0.6163 mL	1.2326 mL	3.0816 mL
	20 mM	0.0924 mL	0.4622 mL	0.9245 mL	2.3112 mL
	25 mM	0.0740 mL	0.3698 mL	0.7396 mL	1.8489 mL
	30 mM	0.0616 mL	0.3082 mL	0.6163 mL	1.5408 mL
	40 mM	0.0462 mL	0.2311 mL	0.4622 mL	1.1556 mL
	50 mM	0.0370 mL	0.1849 mL	0.3698 mL	0.9245 mL
	60 mM	0.0308 mL	0.1541 mL	0.3082 mL	0.7704 mL
	80 mM	0.0231 mL	0.1156 mL	0.2311 mL	0.5778 mL
	100 mM	0.0185 mL	0.0924 mL	0.1849 mL	0.4622 mL