2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. SML-10-70-1

SML-10-70-1 is a ligand for RAS, which covalently modifies the K-Ras G12C mutant protein, and inhibits the phosphorylation of ERK and Akt. SML-10-70-1 inhibits the proliferation of cancer cells H23, H358 and A549 with IC50 of 26.6-47.6 μM.

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SML-10-70-1 Chemical Structure

SML-10-70-1 Chemical Structure

CAS No. : 1536470-98-0

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SML-10-70-1 Related Antibodies

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Description

SML-10-70-1 is a ligand for RAS, which covalently modifies the K-Ras G12C mutant protein, and inhibits the phosphorylation of ERK and Akt. SML-10-70-1 inhibits the proliferation of cancer cells H23, H358 and A549 with IC50 of 26.6-47.6 μM[1].

Molecular Weight

746.04

Formula

C25H42ClN7O13P2
CAS No.
SMILES

O=C1C(N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP(OCCNC(CCl)=O)(N[C@@H](C)C(OCC(CCC)CCC)=O)=O)(O)=O)O3)=C2N=C(N)N1
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SML-10-70-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SML-10-70-11536470-98-0RasH23H358A549Inhibitorinhibitorinhibit

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