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Pathways Recommended:	Metabolic Enzyme/Protease

Results for "

Insulin-degrading enzyme

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Proteolytic Enzyme (2) MMP (1)
By Research Areas:	Cancer (1) Infection (1) Metabolic Disease (4)

4

Inhibitors & Agonists

1

Recombinant Proteins

1

Antibodies

Targets Recommended: Insulin Receptor Proteolytic Enzyme Angiotensin-converting Enzyme (ACE) NEDD8-activating Enzyme E1/E2/E3 Enzyme IGF-1R IRE1 TET Protein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

ML345	Proteolytic Enzyme	Metabolic Disease
ML345 is a potent and selective insulin-degrading enzyme (IDE) small-molecule inhibitor, with an IC₅₀ value of 188 nM. ML345 can be for use as a pharmacophore for agent development in diabetes research .

IDE-IN-2	Proteolytic Enzyme	Infection Metabolic Disease Cancer
IDE-IN-3 (Compound 4) is an inhibitor for **insulin-degrading enzyme**. IDE-IN-3 is predicted to have CYP3A4, CYP2C19, hERG, NADP+, HIF1α and histidine kinase inhibitory activities, and has potential biological activity in anti-diabetic, anti-tumor, anti-bacterial aspects, according to the in silico prediction .

6bK TFA 1 Publications Verification	Others	Metabolic Disease
6bK TFA is a potent and selective insulin degrading enzyme (IDE) inhibitor with an IC₅₀ value of 50 nM. 6bK TFA increases circulating insulin in high-fat-fed mice. Acute administration of 6bK TFA enhances glucose tolerance to oral glucose, notably to a greater extent in high-fat-fed mice .

IDE-IN-1	MMP	Metabolic Disease
IDE-IN-1 (compound 6bK) is an insulin-degrading enzyme (IDE) inhibitor with IC₅₀ value of 50 nM. IDE-IN-1 can be used to study type 2 diabetes .

Cat. No.	Compare	Product Name	Species	Source

	Insulysin/IDE Protein, Human (HEK293, His) rHuInsulin-degrading enzyme/IDE, His ; Insulin-degrading enzyme; Abeta-degrading Protease; Insulin Protease; Insulinase; Insulysin; IDE	Human	HEK293
	Insulin/IDE protein is the key to the decomposition of cellular peptides. It participates in the degradation of insulin, APP peptides, IAPP peptides, natriuretic peptides, glucagon, bradykinin, kinins and other peptides, and affects intercellular peptide signaling. Substrate binding induces conformational changes that promote degradation of larger substrates such as insulin. Insulysin/IDE Protein, Human (HEK293, His) is the recombinant human-derived Insulysin/IDE protein, expressed by HEK293 , with C-6*His labeled tag.

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	Insulin degrading enzyme Antibody	WB, IHC-P	Human, Mouse
	Insulin degrading enzyme Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 118 kDa, targeting to Insulin degrading enzyme. It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse.

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