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Isoforms Recommended:	MEK5

Results for "

MEK5

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Autophagy (1) CaMK (1) ERK (2) MEK (5) Mixed Lineage Kinase (1) p38 MAPK (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (1) Inflammation/Immunology (1) Metabolic Disease (1)

7

Inhibitors & Agonists

1

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

BIX02188 3 Publications Verification	MEK ERK	Cancer
BIX02188 is a potent *MEK5*-selective inhibitor with an IC₅₀ of 4.3 nM. BIX02188 inhibits *ERK5* catalytic activity, with an IC₅₀ of 810 nM.

GW284543 UNC10225170	MEK	Cancer
GW284543 (UNC10225170) is a selective *MEK5* inhibitor. GW284543 reduces pERK5, and decreases endogenous MYC protein .

BIX02189 Maximum Cited Publications 8 Publications Verification	MEK ERK	Cancer
BIX02189 is a potent and selective *MEK5* inhibitor with an IC₅₀ of 1.5 nM. BIX02189 also inhibits *ERK5* catalytic activity with an IC₅₀ of 59 nM.

CS640	CaMK MEK Mixed Lineage Kinase	Cancer
CS640 is a selective inhibitor of calmodulin-dependent kinases. CS640 inhibits CaMK1D, CaMK1B, CaMK1A, CaMK1G, PIP5K1C, MEK5, RIPK4 and MLK3 with IC₅₀ values of 0.08, 0.03, 0.001, 0.001, 11.2, 0.025, 5.69 and 2.75 μM, respectively. CS640 also shows inhibitory effects to CYP450 2C9 and CYP450 2C19 with IC₅₀ values of 6 and 10 μM, respectively .

TA-02 2 Publications Verification	p38 MAPK Autophagy	Cardiovascular Disease Inflammation/Immunology Cancer
TA-02, an analog of SB 203580 (HY-10256), is a p38 MAPK inhibitor with an IC₅₀ of 20 nM. TA-02 especially inhibits TGFBR-2. TA-02 exhibits similar cardiogenic properties as SB 203580 and SB 202190 (HY-10295) .

(E/Z)-BIX02188	Others	Metabolic Disease
(E/Z)-BIX02188 is a MEK5/ERK5 pathway inhibitor. (E/Z)-BIX02188 inhibits the catalytic function of purified MEK5 enzyme.(E/Z)-BIX02188 can be used for the role of MEK5/ERK5 pathway in various biological systems .

GW284543 hydrochloride UNC10225170 hydrochloride	MEK	Cancer
GW284543 (UNC10225170) hydrochloride is a selective *MEK5* inhibitor. GW284543 reduces pERK5, and decreases endogenous MYC protein .

Cat. No.	Compare	Product Name	Application	Reactivity

	MEK5 Antibody (YA3140) MAP2K5; MEK5; MKK5; PRKMK5; Dual specificity mitogen-activated protein kinase kinase 5; MAP kinase kinase 5; MAPKK 5; MAPK/ERK kinase 5; MEK 5	WB, ICC/IF	Human
	MEK5 Antibody (YA3140) is a biotin-conjugated non-conjugated IgG antibody, targeting MEK5, with a predicted molecular weight of 50 kDa. MEK5 Antibody (YA3140) can be used for WB, ICC/IF experiment in human background.

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