2. MAPK/ERK Pathway
  3. MEK
  4. GW284543 hydrochloride

GW284543 hydrochloride  (Synonyms: UNC10225170 hydrochloride)

Cat. No.: HY-114189A
Handling Instructions

Molarity Calculator

GW284543 (UNC10225170) hydrochloride is a selective MEK5 inhibitor. GW284543 reduces pERK5, and decreases endogenous MYC protein.

For research use only. We do not sell to patients.

GW284543 hydrochloride Chemical Structure

GW284543 hydrochloride Chemical Structure

CAS No. : 179246-08-3

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other Forms of GW284543 hydrochloride:

GW284543 hydrochloride Related Antibodies

Top Publications Citing Use of Products

View All MEK Isoform Specific Products:

View All Isoforms
MEK1 MEK2 MEK5 MEK

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

GW284543 (UNC10225170) hydrochloride is a selective MEK5 inhibitor. GW284543 reduces pERK5, and decreases endogenous MYC protein[1].

IC50 & Target[1]

MEK5

 

In Vitro

GW284543 (10 and 20 μM; 6 h) treatment inhibits MEK5 in a dose-dependent manner and reduces pERK5[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GW284543 hydrochloride Related Antibodies

Western Blot Analysis[1]

Cell Line: MIA PaCa-2 cells
Concentration: 10 and 20 μM
Incubation Time: 6 hours
Result: Reduced phosphorylation of ERK5, and decreased endogenous MYC protein.
Molecular Weight

408.88

Formula

C23H21ClN2O3
CAS No.
SMILES

COC1=CC2=C(NC3=CC(OC4=CC=CC=C4)=CC=C3)C=CN=C2C=C1OC.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

GW284543 hydrochloride Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GW284543179246-08-3UNC10225170GW 284543GW-284543UNC 10225170UNC-10225170MEKMitogen-activated protein kinase kinaseMAPKKMAP2KMIA PaCa-2Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
GW284543 hydrochloride
Cat. No.:
HY-114189A
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.