GW284543 hydrochloride (Synonyms: UNC10225170 hydrochloride)

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GW284543 (UNC10225170) hydrochloride is a selective MEK5 inhibitor. GW284543 reduces pERK5, and decreases endogenous MYC protein.

For research use only. We do not sell to patients.

GW284543 hydrochloride Chemical Structure

CAS No. : 179246-08-3

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Other Forms of GW284543 hydrochloride:

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MEK1 MEK2 MEK5 MEK

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Description

GW284543 (UNC10225170) hydrochloride is a selective MEK5 inhibitor. GW284543 reduces pERK5, and decreases endogenous MYC protein^[1].

IC₅₀ & Target^[1]

MEK5

In Vitro

GW284543 (10 and 20 μM; 6 h) treatment inhibits MEK5 in a dose-dependent manner and reduces pERK5^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	MIA PaCa-2 cells
Concentration:	10 and 20 μM
Incubation Time:	6 hours
Result:	Reduced phosphorylation of ERK5, and decreased endogenous MYC protein.

Molecular Weight

408.88

Formula

C₂₃H₂₁ClN₂O₃

CAS No.

179246-08-3

SMILES

COC1=CC2=C(NC3=CC(OC4=CC=CC=C4)=CC=C3)C=CN=C2C=C1OC.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Vaseva AV, et al. KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism. Cancer Cell. 2018 Nov 12;34(5):807-822.e7. [Content Brief]

GW284543 hydrochloride Related Classifications

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GW284543179246-08-3UNC10225170GW 284543GW-284543UNC 10225170UNC-10225170MEKMitogen-activated protein kinase kinaseMAPKKMAP2KMIA PaCa-2Inhibitorinhibitorinhibit

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