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Pathways Recommended:	Metabolic Enzyme/Protease

Results for "

NEDD8-activating Enzyme

" in MedChemExpress (MCE) Product Catalog:

By Targets:	NEDD8-activating Enzyme (6) Apoptosis (1) Microtubule/Tubulin (1)
By Research Areas:	Cancer (8)

8

Inhibitors & Agonists

2

Antibodies

Targets Recommended: NEDD8-activating Enzyme E1/E2/E3 Enzyme Proteolytic Enzyme Angiotensin-converting Enzyme (ACE) FLAP Platelet-activating Factor Receptor (PAFR) ATF6 IRE1 PACAP Receptor TET Protein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Pevonedistat hydrochloride Maximum Cited Publications 145 Publications Verification MLN4924 hydrochloride	NEDD8-activating Enzyme	Cancer
Pevonedistat hydrochloride (MLN4924 hydrochloride) is a potent and selective NEDD8-activating enzyme (NAE) inhibitor, with an IC₅₀ of 4.7 nM .

Pevonedistat Maximum Cited Publications 145 Publications Verification MLN4924	NEDD8-activating Enzyme	Cancer
Pevonedistat (MLN4924) is a potent and selective **NEDD8-activating enzyme (NAE) inhibitor with an IC₅₀** of 4.7 nM .

TAS4464 5 Publications Verification	NEDD8-activating Enzyme	Cancer
TAS4464 is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE), with an IC₅₀ of 0.955 nM .

ZM223 hydrochloride	NEDD8-activating Enzyme	Cancer
ZM223 hydrochloride is an orally active, potent non-covalent NEDD8 activating enzyme (NAE) inhibitor with excellent anticancer activity .

TAS4464 hydrochloride 5 Publications Verification	NEDD8-activating Enzyme	Cancer
TAS4464 (hydrochloride) is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE), with an IC₅₀ of 0.955 nM . TAS4464 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

NAE-IN-M22	Apoptosis	Cancer
NAE-IN-M22 is a potent, selective and reversible inhibitor of NEDD8 activating enzyme (NAE), with potency in micromolar range. NAE-IN-M22 inhibits multiple cancer cell lines and induces apoptosis in A549 cells. NAE-IN-M22 also can inhibit tumor growth in vivo .

Tubulin/NEDDylation-IN-1	Microtubule/Tubulin	Cancer
Tubulin/NEDDylation-IN-1 (compound C11) is a dual inhibitor of tubulin (Microtubule/Tubulin)-NEDDylation (IC₅₀ for tubulin=2.40 μM), which has strong anti-proliferative activity. Neddylation is a protein post-translational modification that covalently tags the ubiquitin-like protein NEDD8 to target proteins. Tubulin/NEDDylation-IN-1 forms hydrogen bonds with residues of tubulin and E1 NEDD8 activating enzyme (NAE) through methoxy and dithiocarbamate groups and inhibits NEDDylation and microtubulin in an ATP-dependent manner. tube polymerization .

ZM223	NEDD8-activating Enzyme	Cancer
ZM223 is a potent non-covalent NEDD8 activating enzyme (NAE) inhibitor, orally active .

Cat. No.	Compare	Product Name	Application	Reactivity

	APPBP1 Antibody (YA2131) NEDD8 activating Enzyme E1 subunit 1; HPP1; ula-1; APPBP1; A-116A10.1	WB, IP	Human
	APPBP1 Antibody (YA2131) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2131), targeting APPBP1, with a predicted molecular weight of 60 kDa (observed band size: 60 kDa). APPBP1 Antibody (YA2131) can be used for WB, IP experiment in human background.

	NEDD8 Activating Enzyme E1C Antibody (YA3296) NAE2; UBE1C; hUBA3	WB	Human, Mouse
	NEDD8 Activating Enzyme E1C Antibody (YA3296) is a biotin-conjugated non-conjugated IgG antibody, targeting NEDD8 Activating Enzyme E1C, with a predicted molecular weight of 52 kDa (observed band size: 52 kDa). NEDD8 Activating Enzyme E1C Antibody (YA3296) can be used for WB experiment in human, mouse background.

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