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Results for "

NTPDase2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Cytochrome P450 (3) Interleukin Related (1) Isotope-Labeled Compounds (1) NTPDase (8) P2X Receptor (1) P2Y Receptor (1) Phosphatase (2) Pyroptosis (2)
By Research Areas:	Cancer (8) Cardiovascular Disease (5) Infection (1) Inflammation/Immunology (5) Neurological Disease (4)

Inhibitors & Agonists

Recombinant Proteins

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-155828

*h-NTPDase-IN-4*	NTPDase	Cancer
h-NTPDase-IN-4 (compound 4c) is a pan-inhibitor of NTPDase with IC50s of 3.58 μM (h-NTPDase1), 10.21 μM (h-NTPDase2), 0.13 μM (h-NTPDase3), 13.57 μM (h- NTPDase8).

HY-100386

Ticlopidine 1 Publications Verification PCR 5332	Cytochrome P450	Cardiovascular Disease
Ticlopidine (PCR 5332), an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC50 of 81.7 μM. Ticlopidine blocks several NTPDase isoenzymes with IC50s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively. Ticlopidine is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine inhibits CYP2C9 and CYP3A4 with IC50s of 26.0 and 32.3 μM, respectively.

HY-123549

PSB-6426	NTPDase	Cancer
PSB-6426 (compund 19a) is a selective human *NTPDase2* inhibitor (K_i=8.2 μM). PSB-6426 can be used in stroke and cancer research .

HY-120566

PSB-16131	Others	Neurological Disease Inflammation/Immunology Cancer
PSB-16131 is a potent inhibitor of human NTPDase2, exhibiting non-competitive inhibition with an IC50 of 539 nM. PSB-16131 has the potential to be a novel therapeutic agent for the treatment of inflammation, neurodegenerative diseases, and cancer.

HY-143289

NTPDase-IN-3	NTPDase	Cardiovascular Disease Cancer
NTPDase-IN-3 (Compound 5e) is a *NTPDase* inhibitor, with IC₅₀ values of: 0.38 μM (NTPDase3), 0.05 μM (NTPDase8), 0.21 μM (NTPDase1), and 1.07 μM (NTPDase2). NTPDase-IN-3 can be used in the research of cancers and thrombosis .

HY-155829

*h-NTPDase-IN-5*	NTPDase	Others
h-NTPDase-IN-5 (compound 3b) is a pan-inhibitor of NTPDase with IC50s of 1.10 μM (h-NTPDase1), 44.73 μM (h-NTPDase2), 26.14 μM (h-NTPDase3), 0.32 μM (h- NTPDase8).

HY-155827

*h-NTPDase-IN-3*	NTPDase	Others
h-NTPDase-IN-3 (compound 4d) is a pan-inhibitor of NTPDase with IC50s of 34.13 μM (h-NTPDase1), 0.33 μM (h-NTPDase2), 23.21 μM (h-NTPDase3), 2.48 μM (h- NTPDase8).

HY-155806

*h-NTPDase-IN-2*	Phosphatase	Others
h-NTPDase-IN-2 (compound 3l) is a pan-inhibitor of h-NTPDase, with IC₅₀s of 0.35 μM (h-NTPDase1), 4.81 μM (h-NTPDase2), 37.73 μM (h-NTPDase3), 10.32 μM (h-NTPDase8), respectively .

HY-100386R

Ticlopidine (Standard)	Cytochrome P450	Cardiovascular Disease
Ticlopidine (Standard) is the analytical standard of Ticlopidine. This product is intended for research and analytical applications. Ticlopidine (PCR 5332), an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC50 of 81.7 μM. Ticlopidine blocks several NTPDase isoenzymes with IC50s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively. Ticlopidine is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine inhibits CYP2C9 and CYP3A4 with IC50s of 26.0 and 32.3 μM, respectively.

HY-100386S

Ticlopidine-d4 PCR 5332-d₄	Isotope-Labeled Compounds Cytochrome P450	Cardiovascular Disease
Ticlopidine-d4 is the deuterium labeled Ticlopidine. Ticlopidine (PCR 5332), an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC50 of 81.7 μM. Ticlopidine blocks several NTPDase isoenzymes with IC50s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively[1]. Ticlopidine is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine inhibits CYP2C9 and CYP3A4 with IC50s of 26.0 and 32.3 μM, respectively[2][3].

HY-103263

PSB-06126	NTPDase	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
PSB-06126 is a selective nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitor, with the K_i values of 0.33 μM for rat NTPDase 1, 19.1 μM for NTPDase 2 and 2.22 μM for NTPDase 3, respectively. PSB-06126 acts on human NTPDase 3 with an IC₅₀ value of 7.76 μM and a K_i value of 4.39 μM ^[2].

HY-143288

NTPDase-IN-2	NTPDase	Infection Inflammation/Immunology Cancer
NTPDase-IN-2 (compound 5g) is a selective *NTPDase* inhibitor with IC₅₀s of 0.04 and 2.27 µM for *h-NTPDase-2/-8, respectively. NTPDase-IN-2 non-competitively inhibits h-NTPDase-1/-2* with a K_m of 74 µM for *h-NTPDase-2. NTPDase*-IN-2 can be used in studies of cancer, immunologic disorders as well as bacterial infections .

HY-103259

Sodium metatungstate Maximum Cited Publications 6 Publications Verification Sodium polyoxotungstate; POM-1	Phosphatase P2X Receptor P2Y Receptor Pyroptosis Interleukin Related	Neurological Disease Inflammation/Immunology Cancer
Sodium metatungstate (Sodium polyoxotungstate) is a *NTPDase* inhibitor, with K_i values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1 (CD39), NTPDase 3 and NTPDase 2 respectively . Sodium metatungstate has anti-inflammatory and anti-cancer effect. Sodium metatungstate inhibits ATP breakdown but also blocks central synaptic transmission ^[2] .

HY-103259A

Sodium metatungstate hydrate Sodium polyoxotungstate hydrate; POM-1 hydrate	NTPDase Pyroptosis	Neurological Disease Inflammation/Immunology Cancer
Sodium metatungstate (Sodium polyoxotungstate; POM-1) hydrate is a *NTPDase* inhibitor, with K_i values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1 (CD39), NTPDase 3 and NTPDase 2 respectively . Sodium metatungstate has anti-inflammatory and anti-cancer effect. Sodium metatungstate inhibits ATP breakdown but also blocks central synaptic transmission ^[2] .

Species:	Human (2) Mouse (1)
Tag:	His (3)
Source:	HEK293 (2) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P72729

	CD39L1/ENTPD2 Protein, Mouse (HEK293, His) Ectonucleoside triphosphate diphosphohydrolase 2; Entpd2; Cd39l1	Mouse	HEK293
	In the nervous system, CD39L1/ENTPD2 protein crucially regulates purinergic neurotransmission by proficiently hydrolyzing ATP and other nucleotides. Remarkably, it exhibits marginal hydrolysis of ADP, emphasizing its specificity and significant role in precisely modulating purinergic signaling pathways. CD39L1/ENTPD2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD39L1/ENTPD2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CD39L1/ENTPD2 Protein, Mouse (HEK293, His) is 437 a.a., with molecular weight of 63-90 kDa.

HY-P72730

	CD39L1/ENTPD2 Protein, Human (HEK293, His) Ectonucleoside triphosphate diphosphohydrolase 2; Entpd2; Cd39l1	Human	HEK293
	CD39L1/ENTPD2 protein, expressed in the nervous system, efficiently hydrolyzes ATP and various nucleotides, while showing limited hydrolysis of ADP. Its substrate specificity hierarchy highlights its regulatory role in purinergic signaling and selective nucleotide hydrolysis, contributing to precise control of neurotransmission. CD39L1/ENTPD2 Protein, Human (HEK293, His) is the recombinant human-derived CD39L1/ENTPD2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CD39L1/ENTPD2 Protein, Human (HEK293, His) is 432 a.a., with molecular weight of ~60 kDa.

HY-P76903

	CD39L1/ENTPD2 Protein, Human (sf9, His) Ectonucleoside triphosphate diphosphohydrolase 2; Entpd2; Cd39l1	Human	Sf9 insect cells
	CD39L1/ENTPD2 protein, expressed in the nervous system, efficiently hydrolyzes ATP and various nucleotides, while showing limited hydrolysis of ADP. Its substrate specificity hierarchy highlights its regulatory role in purinergic signaling and selective nucleotide hydrolysis, contributing to precise control of neurotransmission. CD39L1/ENTPD2 Protein, Human (sf9, His) is the recombinant human-derived CD39L1/ENTPD2 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of CD39L1/ENTPD2 Protein, Human (sf9, His) is 432 a.a., with molecular weight of ~59 kDa.

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Cat. No.	Product Name	Chemical Structure

HY-100386S

Ticlopidine-d4
Ticlopidine-d4 is the deuterium labeled Ticlopidine. Ticlopidine (PCR 5332), an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC50 of 81.7 μM. Ticlopidine blocks several NTPDase isoenzymes with IC50s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively[1]. Ticlopidine is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine inhibits CYP2C9 and CYP3A4 with IC50s of 26.0 and 32.3 μM, respectively[2][3].

Ticlopidine-d4

Ticlopidine-d4 is the deuterium labeled Ticlopidine. Ticlopidine (PCR 5332), an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC50 of 81.7 μM. Ticlopidine blocks several NTPDase isoenzymes with IC50s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively[1]. Ticlopidine is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine inhibits CYP2C9 and CYP3A4 with IC50s of 26.0 and 32.3 μM, respectively[2][3].

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