PSB-6426

Cat. No.: HY-123549: FAQs
Data Sheet Handling Instructions

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PSB-6426 (compund 19a) is a selective human NTPDase2 inhibitor (K_i=8.2 μM). PSB-6426 can be used in stroke and cancer research.

For research use only. We do not sell to patients.

PSB-6426 Chemical Structure

CAS No. : 958459-33-1

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Description

PSB-6426 (compund 19a) is a selective human NTPDase2 inhibitor (K_i=8.2 μM). PSB-6426 can be used in stroke and cancer research^[1].

IC₅₀ & Target^[1]

NTPDase2

8.2 μM (Ki)

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	42 μM Compound: 19a, PSB-6426	Inhibition of human NTPDase 2 expressed in HEK293 cells assessed as residual activity by capillary electrophoresis Inhibition of human NTPDase 2 expressed in HEK293 cells assessed as residual activity by capillary electrophoresis	[PMID: 18630897]

Molecular Weight

540.46

Formula

C₂₂H₂₉N₄O₁₀P

CAS No.

958459-33-1

SMILES

CCOP(CC(C=C1)=CC=C1NC(CNC([C@@H]2[C@@H](O)[C@@H](O)[C@H](N3C(NC(C=C3)=O)=O)O2)=O)=O)(OCC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Brunschweiger, et al. "Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5′-carboxamide." Journal of medicinal chemistry 51.15 (2008): 4518-4528. [Content Brief]

PSB-6426 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PSB-6426958459-33-1PSB6426PSB 6426NTPDaseSelectiveinhibitorsstrokecancerInhibitorinhibitorinhibit

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