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PIN1 degrader-1

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-164895
    PIN1 degrader-1

    		PIN1 Cancer
    PIN1 degrader-1 (Compound 158H9) is the inhibitor for proline cis trans isomerase (Pin1) with an IC50 of 21.5 nM. PIN1 degrader-1 forms covalent bond with Cys113 of Pin1, induces conformational changes in Pin1, reduces its stability, and leads to a proteasome-dependently degradation. PIN1 degrader-1 inhibits the cell viability of multi cancer cells, and can be used in cancer research [1].
    PIN1 degrader-1
  • HY-168037
    PROTAC PIN1 degrader-1

    		PROTACs PIN1 Cancer
    PROTAC PIN1 degrader-1 (compound D4) is a PROTAC targeting PIN1, with a DC50=1.8 nM. The GI50 of PROTAC PIN1 degrader-1 to MDA-MB-468 is >30 μM. PROTAC PIN1 degrader-1 is composed of target protein ligand PIN1 ligand-1 (HY-168038) (red part), E3 ligase ligand Thalidomide (HY-14658) (blue part), and PROTAC linker (black part) [1] .
    PROTAC PIN1 degrader-1
  • HY-168038
    PIN1 ligand-1

    		Ligands for Target Protein for PROTAC Cancer
    PIN1 ligand-1 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). PIN1 ligand-1 can be used for synthesis PROTAC PIN1 degrader-1 (HY-168037) [1].
    PIN1 ligand-1
  • HY-168039
    Boc-NH-Piperidine-C5-OH

    		PROTAC Linkers Cancer
    Boc-NH-Piperidine-C5-OH is a PROTAC linker. Boc-NH-Piperidine-C5-OH can be used in the synthesis of PROTAC PIN1 degrader-1 (HY-168037) [1].
    Boc-NH-Piperidine-C5-OH
  • HY-170429
    BJP-07-017-3

    		PIN1 Cancer
    BJP-07-017-3 is the inhibitor for proline cis trans isomerase (Pin1) with an IC50 of 9 nM. BJP-07-017-3 forms covalent bond with Cys113 of Pin1, induces conformational changes in Pin1, reduces its stability, and leads to a proteasome-dependently degradation .
    BJP-07-017-3
  • HY-168040
    Thalidomide-O-C5-piperidine-NH-Boc

    		E3 Ligase Ligand-Linker Conjugates Cancer
    Thalidomide-O-C5-piperidine-NH-Boc is an E3 Ligase Ligand-Linker Conjugate. Thalidomide-O-C5-piperidine-NH-Boc can be used to synthesize PROTAC PIN1 degrader-1 (HY-168037) [1].
    Thalidomide-O-C5-piperidine-NH-Boc

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