PROTAC PIN1 degrader-1

Cat. No.: HY-168037: FAQs
Data Sheet Handling Instructions

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PROTAC PIN1 degrader-1 (compound D4) is a PROTAC targeting PIN1, with a DC50=1.8 nM. The GI50 of PROTAC PIN1 degrader-1 to MDA-MB-468 is >30 μM. PROTAC PIN1 degrader-1 is composed of target protein ligand PIN1 ligand-1 (HY-168038) (red part), E3 ligase ligand Thalidomide (HY-14658) (blue part), and PROTAC linker (black part)^{[1]^.}

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PROTAC PIN1 degrader-1 Chemical Structure

CAS No. : 3038591-59-9

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Description	PROTAC PIN1 degrader-1 (compound D4) is a PROTAC targeting PIN1, with a DC50=1.8 nM. The GI50 of PROTAC PIN1 degrader-1 to MDA-MB-468 is >30 μM. PROTAC PIN1 degrader-1 is composed of target protein ligand PIN1 ligand-1 (HY-168038) (red part), E3 ligase ligand Thalidomide (HY-14658) (blue part), and PROTAC linker (black part)^{[1]^.}
IC₅₀ & Target	PIN1^[1]
Molecular Weight	917.02
Formula	C₅₁H₅₂N₁₀O₇
CAS No.	3038591-59-9
SMILES	CC1=CC=CN=C1C2(CC2)C(NC(CC(N=N3)=CN3C(C=C4)=CC=C4C(C=C5)=CC=C5C#N)C(NC(CC6)CCN6CCCCCOC7=CC=CC(C8=O)=C7C(N8C(CC9)C(NC9=O)=O)=O)=O)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (268 KB) Handling Instructions (2659 KB)
References	[1]. Liu C, et al. Re-Evaluating PIN1 as a Therapeutic Target in Oncology Using Neutral Inhibitors and PROTACs. J Med Chem. 2024 Sep 12;67(17):15780-15795. [Content Brief]