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SQSTM1/p62

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By Targets:	p62 (1) Androgen Receptor (1) AUTACs (3) AUTOTACs (1) Nuclear Hormone Receptor 4A/NR4A (1)
By Research Areas:	Cancer (4) Inflammation/Immunology (1)

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Natural
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2

Antibodies

Targets Recommended: p62

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Triptohypol C	Nuclear Hormone Receptor 4A/NR4A p62	Inflammation/Immunology
Triptohypol C, a Tripterin (HY-13067) derivative, is a potent Nur77-targeting anti-inflammatory agent with an K_d value of 0.87 μM. Triptohypol C inhibits inflammatory response by promoting the interactions of Nur77 with TRAF2 and p62/SQSTM1 ^[1].

YT 6-2	AUTACs	Cancer
YT 6-2 is the p62/SQSTM1 targeting, autophagy-targeting ligand (ATL) of AUTOTAC ATC-324 (HY-169385), which is an bivalent AR (Androgen Receptor) degrader. ATC-324 can reduce nuclear AR levels and downregulate target gene expression of AR and AR-v7, and also has a degradation effect on common AR mutants in PCa ^[1].

*YT 6-2* analog-1**	AUTACs	Cancer
YT 6-2 analog-1 (compound 2-3) is the p62/SQSTM1 targeting, autophagy-targeting ligand (ATL) of AUTOTAC ATC-324 (HY-169385), which is an bivalent AR (Androgen Receptor) degrader. ATC-324 can reduce nuclear AR levels and downregulate target gene expression of AR and AR-v7, and also has a degradation effect on common AR mutants in PCa ^[1].

YT 6-2-PEG3-C2-NH2	AUTACs	Cancer
YT 6-2-PEG3-C2-NH2 is the *p62/SQSTM1* targeting, autophagy-targeting ligand-linker conjugate of AUTOTAC ATC-324 (HY-169385), which is an bivalent AR (Androgen Receptor) degrader. ATC-324 can reduce nuclear AR levels and downregulate target gene expression of AR and AR-v7, and also has a degradation effect on common AR mutants in PCa ^[1].

ATC-324	AUTOTACs Androgen Receptor	Cancer
ATC-324 is an bivalent AR (Androgen Receptor) degrader based on the protein degradation technology platform AUTOphagy-TArgeting Chimera (AUTOTAC). ATC-324 induces the formation of AR/p62 complex, leading to autophagy-lysosomal degradation of AR. ATC-324 can reduce nuclear AR levels and downregulate target gene expression of AR and AR-v7, and also has a degradation effect on common AR mutants in PCa ^[1]. ATC-324 is composed of target-binding ligand (TBL) Enzalutamide (HY-70002) and p62/SQSTM1 autophagy-targeting ligand (ATL) YT 6-2 analog-1 (HY-169386), connected by Boc-NH-PEG4-CH2CH2NH2 (HY-W008352). Among them, the active control of the target protein ligand is Enzalutamide carboxylic acid (HY-70002B), and the conjugate composed of the autophagy-targeting ligand and the linker is YT 6-2-PEG3-C2-NH2 (HY-169387).

Cat. No.	Compare	Product Name	Application	Reactivity

	SQSTM1/p62 Antibody (YA062) p60; p62; A170; DMRV; OSIL; PDB3; ZIP3; p62B; NADGP; FTDALS3	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse
	SQSTM1/p62 Antibody (YA062) is a non-conjugated and Rabbit origined monoclonal antibody about 48 kDa, targeting to SQSTM1/p62. It can be used for WB,IHC-F,IHC-P,ICC/IF,IP assays with tag free, in the background of Human, Mouse.

	SQSTM1/p62 Antibody (YA669) 1 Publications Verification	IHC-P, FC	Human, Mouse, Rat
	SQSTM1/p62 Antibody (YA669) is a non-conjugated and Mouse origined monoclonal antibody about 62 kDa, targeting to SQSTM1 / p62. It can be used for IHC-P,FC assays with tag free, in the background of Human, Mouse, Rat.

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