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Isoforms Recommended: USP14
Results for "

USP14

" in MedChemExpress (MCE) Product Catalog:

7

Inhibitors & Agonists

3

Recombinant Proteins

1

Antibodies

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-13817
    IU1
    5+ Cited Publications

    		 Deubiquitinase Autophagy Cardiovascular Disease
    IU1 is a special Usp14 inhibitor with an IC50 of 4-5 μM.
    IU1
  • HY-13989
    b-AP15
    5+ Cited Publications

    NSC 687852

    		 Deubiquitinase Apoptosis Cancer
    b-AP15 is a specific inhibitor of the deubiquitinating enzymes UCHL5 and Usp14.
    b-AP15
  • HY-122885
    IU1-248
    1 Publications Verification

    		 Deubiquitinase Cancer
    IU1-248, a derivative of IU1, is a potent and selective USP14 inhibitor with an IC50 of 0.83?μM.
    IU1-248
  • HY-13264
    Degrasyn
    Maximum Cited Publications
    12 Publications Verification

    WP1130

    		 Deubiquitinase Bcr-Abl Autophagy Apoptosis Cancer
    Degrasyn (WP1130) is a cell-permeable deubiquitinase (DUB) inhibitor, directly inhibiting DUB activity of USP9x, USP5, USP14, and UCH37. Degrasyn has been shown to downregulate the antiapoptotic proteins Bcr-Abl and JAK2.
    Degrasyn
  • HY-122243
    IU1-47
    2 Publications Verification

    		 Deubiquitinase Neurological Disease
    IU1-47 is a potent and specific USP14 inhibitor with an IC50 of 0.6 μM. IU1-47 inhibits IsoT/USP5 with an IC50 of 20 μM. IU1-47 induces tau elimination in cultured neurons .
    IU1-47
  • HY-RS15525
    USP14 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    USP14 Human Pre-designed siRNA Set A contains three designed siRNAs for USP14 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    USP14 Human Pre-designed siRNA Set A
    USP14 Human Pre-designed siRNA Set A
  • HY-164689
    Cadmium pyrithione

    		Proteasome Cancer
    Cadmium pyrithione is a metal compound that inhibits protein deubiquitinase activity. Cadmium pyrithione treatment results in significant accumulation of ubiquitinated proteins in cancer cells and primary leukemia cells. Cadmium pyrithione strongly inhibits the activity of proteasome deubiquitinase (such as USP14 and UCHL5), but has a smaller inhibitory effect on 20S proteasome activity. The anticancer activity of Cadmium pyrithione is associated with the induction of apoptosis through caspase activation. Furthermore, Cadmium pyrithione inhibition inhibited proteasome function and suppressed tumor growth in animal xenograft models .
    Cadmium pyrithione

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