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Results for "

Vanilloid

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Apoptosis (2) Bacterial (4) Bcl-2 Family (2) Calcium Channel (2) Cannabinoid Receptor (3) Caspase (2) CGRP Receptor (1) COX (1) Endogenous Metabolite (8) FAAH (1) Histamine Receptor (1) HIV (3) Insulin Receptor (1) Isotope-Labeled Compounds (1) PI3K (2) Reactive Oxygen Species (2) Small Interfering RNA (siRNA) (1) TRP Channel (48)
By Research Areas:	Cancer (7) Cardiovascular Disease (6) Endocrinology (1) Infection (1) Inflammation/Immunology (14) Metabolic Disease (9) Neurological Disease (33)
Oligonucleotides:	siRNAs (2)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-114017

Vanilloid receptor antagonist 1	TRP Channel	Inflammation/Immunology
Vanilloid receptor antagonist 1 is a potent vanilloid receptor TRPV1 antagonist extracted from patent US8349852B2, compound B8 .

HY-101323

Olvanil NE-19550; N-Vanillyloleamide	TRP Channel	Neurological Disease
Olvanil (NE-19550) is an analgesic and an agonist of transient receptor potential vanilloid type 1 (TRPV1) channels with an EC₅₀ of 0.7 nM .

HY-12245

SB-366791 3 Publications Verification	TRP Channel	Inflammation/Immunology
SB-366791 is a potent and selective vanilloid receptor (VR1/TRPV1) antagonist (IC₅₀=5.7 nM). SB-366791 can be used for the research of inflammation .

HY-19608

GSK1016790A Maximum Cited Publications 21 Publications Verification	TRP Channel Calcium Channel	Cardiovascular Disease Metabolic Disease
GSK1016790A is a potent and selective *transient receptor potential vanilloid* 4 (TRPV4)** channel agonist. GSK1016790A can elicit Ca ²⁺ influx and elevate intracellular Ca ²⁺ in HEK cells .

HY-P3702

CEDAEVFKDSMVPGEK	TRP Channel	Others
CEDAEVFKDSMVPGEK is the rat vanilloid receptor subtype 1 (VR1) peptides sequence, can be used to determine the presence and distribution of VR1 .

HY-118299

JYL 1511	TRP Channel	Inflammation/Immunology
JYL 1511 is a partial agonist of vanilloid receptor VR1 .

HY-101389

(R)-Methanandamide AM-356	Cannabinoid Receptor TRP Channel	Neurological Disease
(R)-Methanandamide (AM-356), an analog of the endocannabinoid ligand Anandamide, is a potent CB1 agonist with a K_i of 20 nM. (R)-Methanandamide also activates vanilloid (TRPV1) receptors .

HY-P1175

L-R4W2	TRP Channel	Neurological Disease
L-R4W2 is a potent antagonist of vanilloid receptor 1 (VR1, TRPV1), with an IC₅₀ of 0.1 μM. L-R4W2 may act as a potent analgesic .

HY-P1175A

L-R4W2 TFA	TRP Channel	Neurological Disease
L-R4W2 TFA is a potent antagonist of vanilloid receptor 1 (VR1, TRPV1), with an IC₅₀ of 0.1 μM. L-R4W2 TFA may act as a potent analgesic .

HY-N3230

Murpanicin Murraxocin	TRP Channel	Inflammation/Immunology
Murpanicin (murraxocin) is a coumarin that is a thermosensitive transient receptor potential vanilloid 2 (TRPV2) channel inhibitor. Murpanicin has significant anti-inflammatory and insecticidal effects.

HY-161273

TRPV1 antagonist 6	TRP Channel	Neurological Disease
TRPV1 antagonist 6 (compound 51) is a mode-selective antagonist for transient receptor potential vanilloid member 1 (TRPV1), which shows antagonism with IC₅₀ of 2.85 nM to capsaicin activation and 28.48 % inhibition against proton activation at a 3 µM concentration .

HY-19589

JTS-653	TRP Channel	Neurological Disease Inflammation/Immunology
JTS-653 is a highly potent and selective transient receptor potential vanilloid 1 (TRPV1) antagonist in vitro and in vivo. JTS-653 attenuates chronic pain refractory to non-steroidal anti-inflammatory agents .

HY-135882

OMDM-6	TRP Channel Cannabinoid Receptor Endogenous Metabolite	Neurological Disease
OMDM-6 is a hybrid agonist of vanilloid receptor type 1 (VR1, TRPV1) (EC₅₀=75 nM) and cannabinoid receptor type 1 (CB1) (K_i=3.2 μM). OMDM-6 inhibits anandamide cellular uptake (ACU) with a K_i of 7.0 μM .

HY-135881

OMDM-5	TRP Channel Endogenous Metabolite	Neurological Disease
OMDM-5 is a selective inhibitor of anandamide cellular uptake (ACU), with a K_i of 4.8 μM. OMDM-5 is also a potent vanilloid receptor type 1 (VR1, TRPV1) agonist, with an EC₅₀ of 75 nM, and shows weakly active as cannabinoid receptor type 1 (CB1) ligand (K_i=4.9 μM) .

HY-112202

GSK3395879	TRP Channel	Cardiovascular Disease
GSK3395879 is a selective and orally bioavailable transient receptor potential vanilloid-4 (TRPV4) antagonist with an IC₅₀ of 1 nM for hTRPV4 .

HY-U00330

TRPV antagonist 1	TRP Channel	Inflammation/Immunology
TRPV antagonist 1 is a transient receptor potential vanilloid (TRPV) antagonist, with an IC₅₀ of < 250 nM.

HY-10634

AMG 517 5+ Cited Publications	TRP Channel	Neurological Disease
AMG 517 is a potent and selective vanilloid receptor-1 (TRPV1) antagonist with an IC₅₀ of 0.5 nM.

HY-12777

Asivatrep PAC-14028	TRP Channel	Inflammation/Immunology
Asivatrep (PAC-14028) is a potent and selective transient receptor potential vanilloid type I (TRPV1) antagonist.

HY-19960

BCTC 3 Publications Verification	TRP Channel Insulin Receptor CGRP Receptor	Neurological Disease Metabolic Disease Cancer
BCTC is an orally active current inhibitor of vanilloid receptor type 1 (VR1). BCTC is a transient receptor potential cation channel subfamily M member 8 (TRPM8) and *transient receptor potential vanilloid* 1 (TRPV1)** antagonist. BCTC is an insulin sensitizer and secretor. BCTC has anticancer and analgesic effects .

HY-108460

A-784168	TRP Channel	Neurological Disease
A-784168 is a potent and orally active inhibitor of vanilloid receptor type 1 (TRPV1). Vanilloid receptor type 1 (TRPV1) is a ligand-gated nonselective cation channel that is considered to be an important integrator of various pain stimuli such as endogenous lipids, capsaicin, heat, and low pH. A-784168 has good CNS penetration .

HY-B0545

Probenecid 15+ Cited Publications	TRP Channel Bacterial HIV	Metabolic Disease Cancer
Probenecid is a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels. Probenecid also inhibits pannexin 1 channels.

HY-103333

Arvanil N-Vanillylarachidonamide	TRP Channel Cannabinoid Receptor	Neurological Disease
Arvanil is a ligand for vanilloid receptor 1 (VR1) and cannabinoid 1 (CB1). Arvanil can inhibit spasticity, as a potent neuroprotectant .

HY-132596A

Tivanisiran sodium SYL1001 sodium	TRP Channel	Neurological Disease
Tivanisiran sodium is a siRNA used for the study of dry eye disease. Tivanisiran sodium was designed to silence *transient receptor potential vanilloid* 1 (TRPV1) mRNA** .

HY-10633

SB-705498 5+ Cited Publications	TRP Channel	Neurological Disease
SB-705498 is a potent, selective and orally bioavailable *transient receptor potential vanilloid* 1 (TRPV1) receptor antagonist with a pIC₅₀** of 7.1.

HY-132596

Tivanisiran SYL1001	Small Interfering RNA (siRNA) TRP Channel	Neurological Disease
Tivanisiran (SYL1001) is a siRNA used for the study of dry eye disease. Tivanisiran was designed to silence *transient receptor potential vanilloid* 1 (TRPV1)** .

HY-101736

AMG9810 4 Publications Verification	TRP Channel	Neurological Disease
AMG9810 is a selective and competitive vanilloid receptor 1 (TRPV1) antagonist with IC₅₀ values of 24.5 and 85.6 nM for human and rat TRPV1, repectively.

HY-12195

ABT-239 2 Publications Verification	Histamine Receptor TRP Channel	Neurological Disease Endocrinology
ABT-239 is a novel, highly efficacious, non-imidazole class of H3R antagonist and a transient receptor potential vanilloid type 1 (TRPV1) antagonist.

HY-114400A

TRPV4 agonist-1	TRP Channel	Inflammation/Immunology
TRPV4 agonist-1 is a transient receptor potential vanilloid 4 (TRPV4) agonist with an EC50 of 60 nM in the hTRPV4 Ca2+ assay[1].

HY-120962

N-Arachidonoyl Taurine	TRP Channel	Metabolic Disease
N-Arachidonoyl Taurine is an activator of the transient receptor potential vanilloid TRPV1 and TRPV4, with EC₅₀s value of 28 μM and 21 μM, respectively .

HY-114400

TRPV4 agonist-1 free base	TRP Channel	Inflammation/Immunology
TRPV4 agonist-1 free base is a transient receptor potential vanilloid 4 (TRPV4) agonist with an EC₅₀ of 60 nM in the hTRPV4 Ca ²⁺ assay .

HY-110270A

RN-9893 hydrochloride	TRP Channel	Inflammation/Immunology
RN-9893 Hydrochloride is an orally active antagonist of transient receptor potential vanilloid 4 (TRPV4), with IC₅₀ values of 0.42 and 0.66 μM, for humans and rats, respectively .

HY-B0545S

Probenecid-d14	TRP Channel Bacterial HIV	Metabolic Disease
Probenecid-d₁₄ is the deuterium labeled Probenecid. Probenecid is a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels. Probenecid also inhibits pannexin 1 channels[1][2].

HY-B0545R

Probenecid (Standard) 15+ Cited Publications	TRP Channel Bacterial HIV	Metabolic Disease Cancer
Probenecid (Standard) is the analytical standard of Probenecid. This product is intended for research and analytical applications. Probenecid is a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels. Probenecid also inhibits pannexin 1 channels.

HY-N6825

Hydroxy-α-sanshool 3 Publications Verification	TRP Channel Endogenous Metabolite	Neurological Disease
Hydroxy-α-sanshool is a transient receptor potential ankyrin 1 (TRPA1) and *TRP vanilloid* 1 (TRPV1) agonist with EC₅₀**s of 69 and 1.1 μM, respectively. Hydroxy-α-sanshool can be used for pain research .

HY-113654

AMG 7905	TRP Channel	Others
AMG 7905 is a hypothermia-inducing transient receptor potential vanilloid type 1 (TRPV1) antagonist. AMG 7905 potentiates TRPV1 channels activation by protons and drives the reflectory inhibition of thermogenesis and tail-skin vasoconstriction, while potently blocking channel activation by capsaicin .

HY-N2333

Resiniferatoxin 1 Publications Verification (+)-Resiniferatoxin	TRP Channel	Cardiovascular Disease Cancer
Resiniferatoxin ((+)-Resiniferatoxin), is a selective agonist of *transient receptor potential vanilloid* 1 (TRPV1) receptor** agonist. Resiniferatoxin can be isolated from the Euphorbia resinifera plant. Resiniferatoxin eliminates TRPV1+ primary sensory afferents and blunt cardiac sympathetic afferent reflex for a relatively long period .

HY-19765

GSK2798745 5 Publications Verification	TRP Channel	Cardiovascular Disease
GSK2798745 is a potent, selective, and orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker with IC₅₀s of 1.8 and 1.6 nM for hTRPV4 and rTRPV4, respectively. GSK2798745 can be used in cardiac and respiratory diseases research .

HY-P1651B

SOR-C13 acetate	TRP Channel	Cancer
SOR-C13 acetate is the acetate salt form of SOR-C13 (HY-P1651). SOR-C13 acetate is an antagonist for transient receptor potential vanilloid 6 (TRPV 6), with an IC₅₀ of 14 nM. SOR-C13 acetate inhibits tumor growth in SKOV-3 xenograft mouse model .

HY-136363

MDR-652	TRP Channel	Neurological Disease
MDR-652 is a highly specific and efficacious *transient receptor potential vanilloid* 1 (TRPV1) ligand with agonist activity. The K_is are 11.4 and 23.8 nM for hTRPV1 and rTRPV1, respectively. The EC₅₀**s are 5.05 and 93 nM for hTRPV1 and rTRPV1, respectively. Potent topical analgesic activity .

HY-10635

ABT-102	TRP Channel	Inflammation/Immunology Cancer
ABT-102 is a potent and highly selective Vanilloid Receptor (TRPV1) receptor antagonist. ABT-102 potently and reversibly increases heat pain thresholds and reduced painfulness of suprathreshold oral/cutaneous heat. ABT-102 reduces nociceptive responses of animals in models of inflammatory, bone cancer, postoperative, and osteoarthritic pain .

HY-128479

JYL-273	Others	Neurological Disease
JYL-273 is a TRPV1 agonist, with the IC₅₀ of 361 nM in CHO-TRPV1 cell lines .

HY-103337

N-Arachidonoylserotonin Arachidonyl serotonin; AA-5-HT	FAAH TRP Channel	Neurological Disease
N-Arachidonoylserotonin (Arachidonyl serotonin; AA-5-HT) is a potent fatty acid amide hydrolase (FAAH) inhibitor with an IC₅₀ value of 1~12 µM. N-Arachidonoylserotonin acts also as an antagonist of transient receptor potential vanilloid-type 1 (TRPV1) channels (IC₅₀=70~100 nM). N-Arachidonoylserotonin is analgesic in rodents .

HY-N8264

Moringin 1 Publications Verification	TRP Channel	Neurological Disease Inflammation/Immunology Cancer
Moringin is a potent and selective TRPA1 ion channel natural agonist with an EC₅₀ of 3.14 μM. Moringin does not activate or activates very weakly the vanilloids somatosensory channels TRPV1, TRPV2, TRPV3 and TRPV4, and the melastatin cooling receptor TRPM8. Moringin has hypoglycemic, antimicrobial, anti-inflammatory, anticancer and neuroprotection activities .

HY-12914

V116517	TRP Channel	Neurological Disease Inflammation/Immunology
V116517 is a potent, orally active transient receptor potential vanilloid (TRPV1) antagonist. V116517 shows potent activity in inhibiting both capsaicin (CAP)- and acid (pH 5)-induced currents in rat DRG neurons expressing native TRPV (IC₅₀=423.2 nM for CAP; IC₅₀=180.3 nM for acid). V116517 can be used for the research of pain .

HY-N0361

Dihydrocapsaicin 2 Publications Verification	TRP Channel Reactive Oxygen Species Apoptosis Caspase Bcl-2 Family Akt PI3K	Cardiovascular Disease Neurological Disease
Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat .

HY-N6962

α-Spinasterol	TRP Channel COX Bacterial	Infection Neurological Disease Metabolic Disease
α-Spinasterol is an orally taken antagonist of transient receptor potential vanilloid 1 ( TRPV1), and it's also an inhibitor of COX-1 and COX-2, with IC₅₀ values of 16.17 μM and 7.76 μM, respectively. α-Spinasterol exhibits antibacterial, anti-inflammatory, antidepressant, and antioxidant effects, has the ability to cross the blood-brain barrier, and can improve diabetes in mice .

HY-130358

PDDHV	Calcium Channel	Neurological Disease
PDDHV is a calcium absorption inducer and may achieve 45Ca ²⁺ influx by stimulating vanillic acid receptor VR1. PDDHV induces 45Ca ²⁺ uptake (EC₅₀: 70 nM) in rat dorsal root ganglion neurons (expressing native vanilloid receptors) and calcium mobilization (EC₅₀: 125 nM) in VR1-transfected CHO cells. PDDHV also inhibits [3H]-resiniferatoxin (RTX) binding to the dorsal root ganglion membrane in rats .

HY-N0361S

Dihydrocapsaicin-d3	Isotope-Labeled Compounds	Others
Dihydrocapsaicin-d₃is the deuterium labeledDihydrocapsaicin(HY-N0361) . Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat .

HY-121888

20-HEPE	Others	Metabolic Disease
20-HEPE is a metabolite of eicosapentaenoic acid formed by ω-oxidation of EPA by cytochrome P450 (CYP) ω-oxidases, including human CYP4F3B. At 10 μM, it activates peroxisome proliferator-activated receptor α (PPARα) in COS-7 cells expressing a luciferase reporter gene. 20-HEPE also activates mouse transient receptor potential vanilloid receptor 1 (mTRPV1) in vitro but lacks analgesic activity in rats.

HY-N0361R

Dihydrocapsaicin (Standard)	TRP Channel Reactive Oxygen Species Apoptosis Caspase Bcl-2 Family Akt PI3K	Cardiovascular Disease Neurological Disease
Dihydrocapsaicin (Standard) is the analytical standard of Dihydrocapsaicin. This product is intended for research and analytical applications. Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat .

Cat. No.	Product Name	Target	Research Area

HY-P1651B

SOR-C13 acetate	TRP Channel	Cancer
SOR-C13 acetate is the acetate salt form of SOR-C13 (HY-P1651). SOR-C13 acetate is an antagonist for transient receptor potential vanilloid 6 (TRPV 6), with an IC₅₀ of 14 nM. SOR-C13 acetate inhibits tumor growth in SKOV-3 xenograft mouse model .

HY-P3702

CEDAEVFKDSMVPGEK	TRP Channel	Others
CEDAEVFKDSMVPGEK is the rat vanilloid receptor subtype 1 (VR1) peptides sequence, can be used to determine the presence and distribution of VR1 .

HY-P1175

L-R4W2	TRP Channel	Neurological Disease
L-R4W2 is a potent antagonist of vanilloid receptor 1 (VR1, TRPV1), with an IC₅₀ of 0.1 μM. L-R4W2 may act as a potent analgesic .

HY-P1175A

L-R4W2 TFA	TRP Channel	Neurological Disease
L-R4W2 TFA is a potent antagonist of vanilloid receptor 1 (VR1, TRPV1), with an IC₅₀ of 0.1 μM. L-R4W2 TFA may act as a potent analgesic .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6825

Hydroxy-α-sanshool 3 Publications Verification	Zanthoxylum bungeanum Maxim. Alkaloids Structural Classification Other Alkaloids Source classification Rutaceae Plants Endogenous metabolite	TRP Channel Endogenous Metabolite
Hydroxy-α-sanshool is a transient receptor potential ankyrin 1 (TRPA1) and *TRP vanilloid* 1 (TRPV1) agonist with EC₅₀**s of 69 and 1.1 μM, respectively. Hydroxy-α-sanshool can be used for pain research .

HY-N2333

Resiniferatoxin 1 Publications Verification (+)-Resiniferatoxin	Cardiovascular Disease Euphorbia resinifera O. Berg Classification of Application Fields Source classification Euphorbiaceae Plants Disease Research Fields	TRP Channel
Resiniferatoxin ((+)-Resiniferatoxin), is a selective agonist of *transient receptor potential vanilloid* 1 (TRPV1) receptor** agonist. Resiniferatoxin can be isolated from the Euphorbia resinifera plant. Resiniferatoxin eliminates TRPV1+ primary sensory afferents and blunt cardiac sympathetic afferent reflex for a relatively long period .

HY-N8264

Moringin 1 Publications Verification	Structural Classification Natural Products Neurological Disease Classification of Application Fields Moringa oleifera Lam. Source classification Moringaceae Plants Inflammation/Immunology Disease Research Fields	TRP Channel
Moringin is a potent and selective TRPA1 ion channel natural agonist with an EC₅₀ of 3.14 μM. Moringin does not activate or activates very weakly the vanilloids somatosensory channels TRPV1, TRPV2, TRPV3 and TRPV4, and the melastatin cooling receptor TRPM8. Moringin has hypoglycemic, antimicrobial, anti-inflammatory, anticancer and neuroprotection activities .

HY-N0361

Dihydrocapsaicin 2 Publications Verification	Alkaloids Structural Classification Monophenols Capsicum annuum L. Classification of Application Fields Other Alkaloids Source classification Phenols Metabolic Disease Solanaceae Plants Disease Research Fields	TRP Channel Reactive Oxygen Species Apoptosis Caspase Bcl-2 Family Akt PI3K
Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat .

HY-N6962

α-Spinasterol	Structural Classification Natural Products Plants Caryophyllaceae Melandrium firmum (S. et Z . ) Rohrb.	TRP Channel COX Bacterial
α-Spinasterol is an orally taken antagonist of transient receptor potential vanilloid 1 ( TRPV1), and it's also an inhibitor of COX-1 and COX-2, with IC₅₀ values of 16.17 μM and 7.76 μM, respectively. α-Spinasterol exhibits antibacterial, anti-inflammatory, antidepressant, and antioxidant effects, has the ability to cross the blood-brain barrier, and can improve diabetes in mice .

HY-N3230

Murpanicin Murraxocin	Structural Classification Source classification Rutaceae Coumarins Phenylpropanoids Plants Murraya alata Drake	TRP Channel
Murpanicin (murraxocin) is a coumarin that is a thermosensitive transient receptor potential vanilloid 2 (TRPV2) channel inhibitor. Murpanicin has significant anti-inflammatory and insecticidal effects.

HY-135882

OMDM-6	Structural Classification Alkaloids Monophenols Neurological Disease Classification of Application Fields Other Alkaloids Source classification Phenols Endogenous metabolite Disease Research Fields	TRP Channel Cannabinoid Receptor Endogenous Metabolite
OMDM-6 is a hybrid agonist of vanilloid receptor type 1 (VR1, TRPV1) (EC₅₀=75 nM) and cannabinoid receptor type 1 (CB1) (K_i=3.2 μM). OMDM-6 inhibits anandamide cellular uptake (ACU) with a K_i of 7.0 μM .

HY-135881

OMDM-5	Structural Classification Alkaloids Monophenols Neurological Disease Classification of Application Fields Other Alkaloids Source classification Phenols Endogenous metabolite Disease Research Fields	TRP Channel Endogenous Metabolite
OMDM-5 is a selective inhibitor of anandamide cellular uptake (ACU), with a K_i of 4.8 μM. OMDM-5 is also a potent vanilloid receptor type 1 (VR1, TRPV1) agonist, with an EC₅₀ of 75 nM, and shows weakly active as cannabinoid receptor type 1 (CB1) ligand (K_i=4.9 μM) .

HY-N0361R

Dihydrocapsaicin (Standard)	Alkaloids Structural Classification Monophenols Capsicum annuum L. Other Alkaloids Source classification Phenols Solanaceae Plants	TRP Channel Reactive Oxygen Species Apoptosis Caspase Bcl-2 Family Akt PI3K
Dihydrocapsaicin (Standard) is the analytical standard of Dihydrocapsaicin. This product is intended for research and analytical applications. Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat .

HY-135880A

OMDM-4	Structural Classification Alkaloids Monophenols Neurological Disease Classification of Application Fields Other Alkaloids Source classification Phenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
OMDM-4 is a selective and metabolically stable inhibitor of anandamide cellular uptake (ACU), with a K_i 17.7 μM .

HY-121557

OMDM-1	Structural Classification Alkaloids Monophenols Neurological Disease Classification of Application Fields Other Alkaloids Source classification Phenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
OMDM-1 is a potent, selective and metabolically stable inhibitor of anandamide cellular uptake (ACU), with a K_i of 2.4 μM .

HY-135880

OMDM-3	Structural Classification Alkaloids Monophenols Neurological Disease Classification of Application Fields Other Alkaloids Source classification Phenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
OMDM-3 is a selective and metabolically stable inhibitor of anandamide cellular uptake (ACU), with a K_i of 16.6 μM .

HY-103342

OMDM-2	Structural Classification Alkaloids Monophenols Neurological Disease Classification of Application Fields Other Alkaloids Source classification Phenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
OMDM-2 is a potent, selective and metabolically stable inhibitor of anandamide cellular uptake (ACU), with a K_i of 3.0 μM .

Cat. No.	Product Name	Chemical Structure

HY-B0545S

Probenecid-d14
Probenecid-d₁₄ is the deuterium labeled Probenecid. Probenecid is a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels. Probenecid also inhibits pannexin 1 channels[1][2].

HY-N0361S

Dihydrocapsaicin-d3

Dihydrocapsaicin-d₃is the deuterium labeledDihydrocapsaicin(HY-N0361) . Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat .

Cat. No.	Product Name		Classification

HY-132596A

Tivanisiran sodium SYL1001 sodium		siRNAs
Tivanisiran sodium is a siRNA used for the study of dry eye disease. Tivanisiran sodium was designed to silence *transient receptor potential vanilloid* 1 (TRPV1) mRNA** .

HY-132596

Tivanisiran SYL1001		siRNAs
Tivanisiran (SYL1001) is a siRNA used for the study of dry eye disease. Tivanisiran was designed to silence *transient receptor potential vanilloid* 1 (TRPV1)** .

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