Tivanisiran (Synonyms: SYL1001)

Cat. No.: HY-132596: FAQs
Data Sheet SDS Handling Instructions

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Tivanisiran (SYL1001) is a siRNA used for the study of dry eye disease. Tivanisiran was designed to silence transient receptor potential vanilloid 1 (TRPV1).

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Tivanisiran sodium) that retains the same biological activity.

For research use only. We do not sell to patients.

RNA, (A-A-G-C-G-C-A-U-C-U-U-C-U-A-C-U-U-C-A), complex with RNA (U-G-A-A-G-U-A-G-A-A-G-A-U-G-C-G-C-U-U) (1:1)

Tivanisiran Chemical Structure

CAS No. : 1848224-71-4

Size	Price	Stock
1 mg	USD 115	Ask For Quote & Lead Time
5 mg	USD 270	Ask For Quote & Lead Time
10 mg	USD 486	Ask For Quote & Lead Time
25 mg	USD 956	Ask For Quote & Lead Time

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other Forms of Tivanisiran:

Tivanisiran sodium Get quote
Tivanisiran triethylamine Get quote

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TRPC TRPM TRPV TRPA TRPML

Biological Activity
Purity & Documentation
References
Customer Review

Description

Tivanisiran (SYL1001) is a siRNA used for the study of dry eye disease. Tivanisiran was designed to silence transient receptor potential vanilloid 1 (TRPV1)^[1].

In Vitro

In vitro transfection of tivanisiran was shown to produce a 50-60% decrease in TRPV1 mRNA levels^[1]^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

12068.30 (AS: 5294.6 + SS: 6125.7)

CAS No.

1848224-71-4

Appearance

Solid

Color

White to off-white

Sequence

RNA, (A-A-G-C-G-C-A-U-C-U-U-C-U-A-C-U-U-C-A), complex with RNA (U-G-A-A-G-U-A-G-A-A-G-A-U-G-C-G-C-U-U) (1:1)

SMILES

[Tivanisiran]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (Need ultrasonic)

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 25 mg/mL; Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Data Sheet (266 KB) SDS (252 KB) Handling Instructions (2659 KB)

References

[1]. Anne-Marie Bleau, et al. Development of tivanisiran, a topical siRNA designed to

[2]. Javier Moreno-Montañés, et al. Tivanisiran, a novel siRNA for the treatment of dry eye disease. Expert Opin Investig Drugs. 2018 Apr;27(4):421-426. [Content Brief]

Tivanisiran Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tivanisiran1848224-71-4SYL1001SYL 1001SYL-1001Small Interfering RNA (siRNA)TRP ChannelTransient receptor potential channelsDryeyediseaseDEDTRPV1Inhibitorinhibitorinhibit

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