2. Membrane Transporter/Ion Channel Neuronal Signaling Anti-infection
  3. TRP Channel Bacterial HIV
  4. Probenecid-d14

Probenecid-d14 is the deuterium labeled Probenecid. Probenecid is a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels. Probenecid also inhibits pannexin 1 channels[1][2].

For research use only. We do not sell to patients.

Probenecid-d<sub>14</sub> Chemical Structure

Probenecid-d14 Chemical Structure

CAS No. : 1189657-87-1

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Based on 1 publication(s) in Google Scholar

Other Forms of Probenecid-d14:

Probenecid-d14 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

Probenecid-d14 is the deuterium labeled Probenecid. Probenecid is a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels. Probenecid also inhibits pannexin 1 channels[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Probenecid-d14 Related Antibodies
Molecular Weight

299.45

Formula

C13H5D14NO4S
CAS No.
Unlabeled CAS

57-66-9
Appearance

Solid

Color

White to off-white

SMILES

S(N(C(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H])C(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H])(=O)(=O)C1=CC=C(C(O)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 30 mg/mL (100.18 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3395 mL 16.6973 mL 33.3946 mL
5 mM 0.6679 mL 3.3395 mL 6.6789 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.0%

COA (261 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3395 mL 16.6973 mL 33.3946 mL 83.4864 mL
5 mM 0.6679 mL 3.3395 mL 6.6789 mL 16.6973 mL
10 mM 0.3339 mL 1.6697 mL 3.3395 mL 8.3486 mL
15 mM 0.2226 mL 1.1132 mL 2.2263 mL 5.5658 mL
20 mM 0.1670 mL 0.8349 mL 1.6697 mL 4.1743 mL
25 mM 0.1336 mL 0.6679 mL 1.3358 mL 3.3395 mL
30 mM 0.1113 mL 0.5566 mL 1.1132 mL 2.7829 mL
40 mM 0.0835 mL 0.4174 mL 0.8349 mL 2.0872 mL
50 mM 0.0668 mL 0.3339 mL 0.6679 mL 1.6697 mL
60 mM 0.0557 mL 0.2783 mL 0.5566 mL 1.3914 mL
80 mM 0.0417 mL 0.2087 mL 0.4174 mL 1.0436 mL
100 mM 0.0334 mL 0.1670 mL 0.3339 mL 0.8349 mL
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Probenecid-d14 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Probenecid-d141189657-87-1TRP ChannelBacterialHIVTransient receptor potential channelsHuman immunodeficiency virusInhibitorinhibitorinhibit

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