(R)-Methanandamide (Synonyms: AM-356)

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(R)-Methanandamide (AM-356), an analog of the endocannabinoid ligand Anandamide, is a potent CB1 agonist with a K_i of 20 nM. (R)-Methanandamide also activates vanilloid (TRPV1) receptors.

For research use only. We do not sell to patients.

(R)-Methanandamide Chemical Structure

CAS No. : 157182-49-5

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5 mg	USD 110	Ask For Quote & Lead Time
10 mg	USD 170	Ask For Quote & Lead Time
25 mg	USD 340	Ask For Quote & Lead Time

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target^[1]^[2]

CB1

20 nM (Ki)

TRPV1

In Vitro

The endogenous cannabinoid (R)-Methanandamide exerts differential anti- and pronociceptive effects by activating both cannabinoid (CB1) and vanilloid (TRPV1) receptors of nociceptive primary afferents^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

361.56

Formula

C₂₃H₃₉NO₂

CAS No.

157182-49-5

SMILES

CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(N[C@H](C)CO)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. V Abadji, et al. (R)-methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability. J Med Chem. 1994 Jun 10;37(12):1889-93. [Content Brief]

[2]. M J M Fischer, et al. Cannabinoid and vanilloid effects of R(+)-methanandamide in the hemisected meningeal preparation. Cephalalgia. 2007 May;27(5):422-8. [Content Brief]

(R)-Methanandamide Related Classifications

Neurological Disease

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-Methanandamide157182-49-5AM-356AM356AM 356Cannabinoid ReceptorTRP ChannelTransient receptor potential channelsCB1endocannabinoidAnandamidevanilloidTRPV1Inhibitorinhibitorinhibit

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