2. GPCR/G Protein Neuronal Signaling Membrane Transporter/Ion Channel
  3. Cannabinoid Receptor TRP Channel
  4. (R)-Methanandamide

(R)-Methanandamide (AM-356), an analog of the endocannabinoid ligand Anandamide, is a potent CB1 agonist with a Ki of 20 nM. (R)-Methanandamide also activates vanilloid (TRPV1) receptors.

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(R)-Methanandamide Chemical Structure

(R)-Methanandamide Chemical Structure

CAS No. : 157182-49-5

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Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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(R)-Methanandamide Related Antibodies

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Description

(R)-Methanandamide (AM-356), an analog of the endocannabinoid ligand Anandamide, is a potent CB1 agonist with a Ki of 20 nM. (R)-Methanandamide also activates vanilloid (TRPV1) receptors[1][2].

IC50 & Target[1][2]

CB1

20 nM (Ki)

TRPV1

 

In Vitro

The endogenous cannabinoid (R)-Methanandamide exerts differential anti- and pronociceptive effects by activating both cannabinoid (CB1) and vanilloid (TRPV1) receptors of nociceptive primary afferents[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(R)-Methanandamide Related Antibodies
Molecular Weight

361.56

Formula

C23H39NO2
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(N[C@H](C)CO)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (553.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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  • Dilution Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7658 mL 13.8290 mL 27.6579 mL 69.1448 mL
5 mM 0.5532 mL 2.7658 mL 5.5316 mL 13.8290 mL
10 mM 0.2766 mL 1.3829 mL 2.7658 mL 6.9145 mL
15 mM 0.1844 mL 0.9219 mL 1.8439 mL 4.6097 mL
20 mM 0.1383 mL 0.6914 mL 1.3829 mL 3.4572 mL
25 mM 0.1106 mL 0.5532 mL 1.1063 mL 2.7658 mL
30 mM 0.0922 mL 0.4610 mL 0.9219 mL 2.3048 mL
40 mM 0.0691 mL 0.3457 mL 0.6914 mL 1.7286 mL
50 mM 0.0553 mL 0.2766 mL 0.5532 mL 1.3829 mL
60 mM 0.0461 mL 0.2305 mL 0.4610 mL 1.1524 mL
80 mM 0.0346 mL 0.1729 mL 0.3457 mL 0.8643 mL
100 mM 0.0277 mL 0.1383 mL 0.2766 mL 0.6914 mL
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(R)-Methanandamide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-Methanandamide157182-49-5AM-356AM356AM 356Cannabinoid ReceptorTRP ChannelTransient receptor potential channelsCB1endocannabinoidAnandamidevanilloidTRPV1Inhibitorinhibitorinhibit

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