2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. Olvanil

Olvanil  (Synonyms: NE-19550; N-Vanillyloleamide)

Cat. No.: HY-101323 Purity: ≥98.0%
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Olvanil (NE-19550) is an analgesic and an agonist of transient receptor potential vanilloid type 1 (TRPV1) channels with an EC50 of 0.7 nM.

For research use only. We do not sell to patients.

Olvanil Chemical Structure

Olvanil Chemical Structure

CAS No. : 58493-49-5

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Based on 1 publication(s) in Google Scholar

Olvanil Related Antibodies

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Description

Olvanil (NE-19550) is an analgesic and an agonist of transient receptor potential vanilloid type 1 (TRPV1) channels with an EC50 of 0.7 nM[1].

IC50 & Target[1]

TRPV1

0.7 nM (EC50)

In Vitro

Olvanil affects C6 glioma cell proliferation (IC50?value of 5.5 μM)[2]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Olvanil Related Antibodies
In Vivo

Olvanil is one capsaicin analog, which acts as an agonist at the vanilloid receptor.?Olvanil may have causes an anxiogenic-like effect.?Doses of 0, 0.2, 1.0 and 5.0 mg/kg Olvanil, respectively, yielded percent open arm entries at 5 min of 25±10.1, 19.3±7.1, 14.9±5.9 and 0±0[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats weighing approximately 200 g[3]
Dosage: 0, 0.2, 1.0 and 5.0 mg/kg
Administration: Injected intraperitoneally 30 min before the behavioral tests
Result: The percent open arm times at 5 min were 12.9±8.1 for the 0 mg/kg dose, 8.9±4.2 for the 0.2 mg/kg dose, 15.2±7.9 for the 1 mg/kg dose and 0±0 for the 5 mg/kg dose.
The mean number of entries into the closed arm at 5 min were 1.7±0.3, 3.3±0.8, 2.7±0.3 and 0.25±0.1 for doses of 0, 0.2, 1 and 5 mg/kg, respectively. 
Clinical Trial
Molecular Weight

417.62

Formula

C26H43NO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCC/C=C\CCCCCCCC(NCC1=CC=C(O)C(OC)=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (239.45 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3945 mL 11.9726 mL 23.9452 mL
5 mM 0.4789 mL 2.3945 mL 4.7890 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (239 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3945 mL 11.9726 mL 23.9452 mL 59.8630 mL
5 mM 0.4789 mL 2.3945 mL 4.7890 mL 11.9726 mL
10 mM 0.2395 mL 1.1973 mL 2.3945 mL 5.9863 mL
15 mM 0.1596 mL 0.7982 mL 1.5963 mL 3.9909 mL
20 mM 0.1197 mL 0.5986 mL 1.1973 mL 2.9932 mL
25 mM 0.0958 mL 0.4789 mL 0.9578 mL 2.3945 mL
30 mM 0.0798 mL 0.3991 mL 0.7982 mL 1.9954 mL
40 mM 0.0599 mL 0.2993 mL 0.5986 mL 1.4966 mL
50 mM 0.0479 mL 0.2395 mL 0.4789 mL 1.1973 mL
60 mM 0.0399 mL 0.1995 mL 0.3991 mL 0.9977 mL
80 mM 0.0299 mL 0.1497 mL 0.2993 mL 0.7483 mL
100 mM 0.0239 mL 0.1197 mL 0.2395 mL 0.5986 mL
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Olvanil Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Olvanil58493-49-5NE-19550 N-VanillyloleamideNE19550NE 19550TRP ChannelTransient receptor potential channelsvanilloidTRPV1channelanalgesicInhibitorinhibitorinhibit

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