fetal hemoglobin

By Targets:	Antibiotic (3) Autophagy (2) Biochemical Assay Reagents (1) HIF/HIF Prolyl-Hydroxylase (1) Histone Acetyltransferase (3) Histone Demethylase (1) Histone Methyltransferase (4) Influenza Virus (2) Molecular Glues (2) VSV (2)
By Research Areas:	Cancer (6) Cardiovascular Disease (3) Infection (2) Inflammation/Immunology (1) Metabolic Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113427A

cis-Vaccenic acid	Antibiotic	Cancer
cis-Vaccenic acid, the antiviral extract from Rhodopseudomonas capsulate and the predominant active component of Rhodopseudomonas capsulate , acts a potential fetal hemoglobin inducer .

HY-15641

FG-2216 3 Publications Verification IOX3; YM311	HIF/HIF Prolyl-Hydroxylase	Metabolic Disease
FG-2216 (IOX3) is a potent and orally active inhibitor of HIF prolyl hydroxylase-2 (PHD2), with an IC₅₀ of 3.9 μM. FG-2216 induces robust erythropoietin and modest fetal hemoglobin in vivo .

HY-P3180

Hemoglobin S	Biochemical Assay Reagents	Others
Abnormality of Hemoglobin is the main cause of sickle cell disease (SCD). Hemoglobin can be used in the determination of fetal hemoglobin by time-resolved immunofluorescence assay .

HY-100826

TN1	Others	Cardiovascular Disease
TN1 is a potent fetal hemoglobin (HbF) inducer.

HY-167874

ASP-8731	Others	Inflammation/Immunology
ASP8731 is a selective inhibitor of BACH1. ASP8731 inhibits inflammation and vaso-occlusion and induces fetal hemoglobin in sickle cell disease .

HY-113427AR

cis-Vaccenic acid (Standard)	Antibiotic	Cancer
cis-Vaccenic acid (Standard) is the analytical standard of cis-Vaccenic acid. This product is intended for research and analytical applications. cis-Vaccenic acid, the antiviral extract from Rhodopseudomonas capsulate and the predominant active component of Rhodopseudomonas capsulate , acts a potential fetal hemoglobin inducer .

HY-145356

HbF inducer-1	Others	Others
HbF inducer-1 is an orally bioavailable fetal hemoglobin inducer.

HY-113427AS

cis-Vaccenic acid-d13	Antibiotic	Cancer
cis-Vaccenic acid-d₁₃ is the deuterium labeled cis-Vaccenic acid. cis-Vaccenic acid, the antiviral extract from Rhodopseudomonas capsulate and the predominant active component of Rhodopseudomonas capsulate[1], acts a potential fetal hemoglobin inducer[2].

HY-162665

WIZ degrader 1	Histone Methyltransferase	Others
WIZ degrader 1 (Compound 141) is a degrader for widely interspaced zinc finger motifs (WIZ) with an AC₅₀ of 2 nM. WIZ degrader 1 induces the expression of fetal hemoglobin (HbF) with an EC₅₀ of 6 mM. WIZ degrader 1 is used in research of inherited blood disorders .

HY-163818

WIZ degrader 2	Histone Methyltransferase	Others
WIZ degrader 2 (Compound 142) is a degrader for widely interspaced zinc finger motifs with an AC₅₀ of 0.011 μM. WIZ degrader 2 induces the expression of **fetal hemoglobin (HbF) with an EC₅₀** of 0.038 μM. WIZ degrader 2 can be used in research about inherited blood disorders .

HY-163819

WIZ degrader 3	Histone Acetyltransferase	Cardiovascular Disease
WIZ degrader 3 (Compound 29) is a degrader for widely interspaced zinc finger motifs (WIZ), with an AC₅₀ of 6.4 nM. WIZ degrader 3 induces the expression of fetal hemoglobin (HbF), with an EC₅₀ of 45 nM. WIZ degrader 3 can be used for the research of blood disorders, such as sickle cell disease and β- thalassemia .

HY-159098

dWIZ-1	Molecular Glues Histone Acetyltransferase	Others
dWIZ-1 is a potent WIZ molecular glue degrader. dWIZ-1 recruitments WIZ(ZF7) to cereblon (CRBN) induces WIZ degradation. dWIZ-1 has the potential for the research of sickle cell disease (SCD) .

HY-159099

HbF inducer 2	Molecular Glues Histone Acetyltransferase	Others
HbF inducer 3 (Compound dWIZ-2) is an orally active molecular glue, which degrades the WIZ transcription factor (DC₅₀=13 nM in primary human erythroid precursor cell) and induces the expression of fetal hemoglobin (HbF) (EC₅₀=100 nM). HbF inducer 3 exhibits good pharmacokinetic characteristics in cynomolgus monkeys .

HY-110130

RN-1 dihydrochloride	Histone Demethylase	Cardiovascular Disease Cancer
RN-1 dihydrochloride is a potent, brain-penetrant, irreversible and selective lysine-specific demethylase 1 (LSD1) inhibitor with an IC₅₀ of 70 nM. RN-1 dihydrochloride exhibits selectivity for LSD1 over MAO-A and MAO-B with IC₅₀ values of 0.51 μM and 2.785 μM respectively .

HY-15273

UNC0638 Maximum Cited Publications 8 Publications Verification	VSV Histone Methyltransferase Autophagy Influenza Virus	Infection Cancer
UNC0638 selectively inhibits G9a and GLP histone methyltransferases with IC₅₀ of 15 nM and 19 nM, respectively. UNC0638 inhibits TNBC cell invasion and migration in vitro. UNC0638 is also an inhibitor of EHMT1/2 and induces fetal hemoglobin (HbF) expression in human erythroid progenitor cell culture. In addition, UNC0638 has anti-FMDV (foot-and-mouth disease virus) and anti-VSV (vesicular stomatitis virus) activities, with excellent potency and selectivity against multiple epigenetic and non-epigenetic targets .

HY-110093

UNC0638 hydrate	VSV Histone Methyltransferase Autophagy Influenza Virus	Infection Cancer
UNC0638 hydrate selectively inhibits G9a and GLP histone methyltransferases with IC₅₀ of 15 nM and 19 nM, respectively. UNC0638 hydrate inhibits TNBC cell invasion and migration in vitro. UNC0638 hydrate is also an inhibitor of EHMT1/2 and induces fetal hemoglobin (HbF) expression in human erythroid progenitor cell culture. In addition, UNC0638 hydrate has anti-FMDV (foot-and-mouth disease virus) and anti-VSV (vesicular stomatitis virus) activities, with excellent potency and selectivity against multiple epigenetic and non-epigenetic targets .

Cat. No.	Product Name	Type

HY-P3180

Hemoglobin S	Native Proteins
Abnormality of Hemoglobin is the main cause of sickle cell disease (SCD). Hemoglobin can be used in the determination of fetal hemoglobin by time-resolved immunofluorescence assay .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113427A

cis-Vaccenic acid	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Cancer	Antibiotic
cis-Vaccenic acid, the antiviral extract from Rhodopseudomonas capsulate and the predominant active component of Rhodopseudomonas capsulate , acts a potential fetal hemoglobin inducer .

HY-113427AR

cis-Vaccenic acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Antibiotic
cis-Vaccenic acid (Standard) is the analytical standard of cis-Vaccenic acid. This product is intended for research and analytical applications. cis-Vaccenic acid, the antiviral extract from Rhodopseudomonas capsulate and the predominant active component of Rhodopseudomonas capsulate , acts a potential fetal hemoglobin inducer .

Cat. No.	Product Name	Chemical Structure

HY-113427AS

cis-Vaccenic acid-d13
cis-Vaccenic acid-d₁₃ is the deuterium labeled cis-Vaccenic acid. cis-Vaccenic acid, the antiviral extract from Rhodopseudomonas capsulate and the predominant active component of Rhodopseudomonas capsulate[1], acts a potential fetal hemoglobin inducer[2].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82819

	Fetal Hemoglobin Antibody (YA2564) Gamma 1 globin; Gamma 2 globin; Gamma A hemoglobin; Gamma globin; Hb F Agamma; Hb F Ggamma; HBG1; HBG2; HBGA; HBGR	WB	Human
	Fetal Hemoglobin Antibody (YA2564) is a biotin-conjugated non-conjugated IgG antibody, targeting Fetal Hemoglobin, with a predicted molecular weight of 16 kDa (observed band size: 12 kDa). Fetal Hemoglobin Antibody (YA2564) can be used for WB experiment in human background.

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fetal hemoglobin

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