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Results for "

hPBMCs

" in MedChemExpress (MCE) Product Catalog:

10

Inhibitors & Agonists

2

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N1346
    Robinin
    2 Publications Verification

    		 Toll-like Receptor (TLR) Apoptosis Inflammation/Immunology
    Robinin is a flavonoid that can be extracted from the leaves of purple cowpea, inhibiting TGF-β, TLR4/NF-κB and TLR2-PI3k-AKT signaling pathways. Robinin exerts anti-inflammatory and anti-tumor effects. The combination of Robinin and Methotrexate (HY-14519) reduces inflammation in experimental arthritis, Robinin can decrease the Doxorubicin (HY-15142A) induced cardiac toxicity effect .
    Robinin
  • HY-162074
    Nipamovir

    		HIV Infection
    Nipamovir is a nitroimidazole prodrug. Nipamovir shows comparable antiviral activity to SAMT-247 (HY-102077) and NS-1040 in both cellular assays and a human ex vivo model of HIV infection, along with low toxicity. Nipamovir has EC50 values of 3.64±3.28 and 3.23±2.81 μM for CEM-SS/HIV-1RF and hPBMC/HIV-192HT599, respectively .
    Nipamovir
  • HY-17015A
    Peramivir
    Maximum Cited Publications
    10 Publications Verification

    RWJ-270201; BCX-1812

    		 IKK JNK STAT p38 MAPK ERK Infection Inflammation/Immunology
    Peramivir is an novel cyclopentane neuraminidase inhibitor of influenza virus. Peramivir has antiviral activity and anti-cytokines stom effects. Peramivir can be used for the research of COVID-19 .
    Peramivir
  • HY-17015
    Peramivir trihydrate
    Maximum Cited Publications
    10 Publications Verification

    RWJ 270201 trihydrate; BCX 1812 trihydrate

    		 Influenza Virus IKK JNK STAT p38 MAPK ERK Infection Inflammation/Immunology
    Peramivir trihydrate (RWJ-270201 trihydrate) is a highly potent, selective and orally active influenza virus neuraminidase (NA) inhibitor, with IC50 values ranging from 0.9 to 4.3 nM for nine NA subtypes .
    Peramivir trihydrate
  • HY-156174
    E104

    		Toll-like Receptor (TLR) ADC Cytotoxin Cancer
    E104 (compound 1) is a potent and selective TLR7 agonist. E104 can be delivered by antibody-drug conjugate (ADC) technology to elicit potent anticancer activity. E104 induces the activation of mouse macrophages and hPBMCs .
    E104
  • HY-156175
    TLR7 agonist 14

    		Toll-like Receptor (TLR) Inflammation/Immunology
    TLR7 agonist 14 (compound 17b) is a highly potent TLR7 agonist with an EC50 of 18 nM. TLR7 agonist 14 potently induces the activation of mouse macrophages and hPBMCs at low-nanomolar concentrations .
    TLR7 agonist 14
  • HY-156176
    TLR7 agonist 15

    		Toll-like Receptor (TLR) Inflammation/Immunology
    TLR7 agonist 15 (compound 16b) is a highly potent TLR7 agonist with an EC50 of 18 nM. TLR7 agonist 15 potently induces the activation of mouse macrophages and hPBMCs at low-nanomolar concentrations .
    TLR7 agonist 15
  • HY-156177
    TLR7 agonist 16

    		Toll-like Receptor (TLR) Inflammation/Immunology
    TLR7 agonist 16 (compound 16d) is a highly potent TLR7 agonist with an EC50 of 18 nM. TLR7 agonist 16 potently induces the activation of mouse macrophages and hPBMCs at low-nanomolar concentrations .
    TLR7 agonist 16
  • HY-153952
    Immuno modulator-1

    		TNF Receptor Interleukin Related Potassium Channel Inflammation/Immunology Cancer
    Immuno modulator-1 (compound 22) inhibits TNFα and IL-2 secretion in human peripheral blood mononuclear cells (hPBMC), with IC50 values of 4.7 and 26 nM, respectively. Immuno modulator-1 shows hERG potassium channel blocking effect, with Inhibitory percentage of 20% at 3 μM .
    Immuno modulator-1
  • HY-N1346R
    Robinin (Standard)

    		Toll-like Receptor (TLR) Apoptosis Inflammation/Immunology
    Robinin (Standard) is the analytical standard of Robinin. This product is intended for research and analytical applications. Robinin is a flavonoid that can be extracted from the leaves of purple cowpea, inhibiting TGF-β, TLR4/NF-κB and TLR2-PI3k-AKT signaling pathways. Robinin exerts anti-inflammatory and anti-tumor effects. The combination of Robinin and Methotrexate (HY-14519) reduces inflammation in experimental arthritis, Robinin can decrease the Doxorubicin (HY-15142A) induced cardiac toxicity effect .
    Robinin (Standard)

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