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Results for "

ionophore

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (27) Apoptosis (19) Autophagy (9) Bacterial (31) Biochemical Assay Reagents (1) Calcium Channel (4) Cuproptosis (4) Estrogen Receptor/ERR (1) Fluorescent Dye (1) Fungal (10) HIF/HIF Prolyl-Hydroxylase (1) Histamine Receptor (1) HSP (1) Influenza Virus (1) Leukotriene Receptor (1) Lipoxygenase (5) Mitochondrial Metabolism (1) Mitophagy (1) Na+/H+ Exchanger (NHE) (3) NF-κB (2) NOD-like Receptor (NLR) (2) Oxidative Phosphorylation (5) Parasite (14) Phospholipase (1) PKC (2) Potassium Channel (3) Proton Pump (2) Pyroptosis (1) Reactive Oxygen Species (1) Sodium Channel (2) Wnt (8) β-catenin (5)
By Research Areas:	Cancer (25) Cardiovascular Disease (2) Endocrinology (1) Infection (30) Inflammation/Immunology (10) Metabolic Disease (3) Neurological Disease (3)

By Targets:

Antibiotic (27)

Apoptosis (19)

Autophagy (9)

Bacterial (31)

Biochemical Assay Reagents (1)

Calcium Channel (4)

Cuproptosis (4)

Estrogen Receptor/ERR (1)

Fluorescent Dye (1)

Fungal (10)

HIF/HIF Prolyl-Hydroxylase (1)

Histamine Receptor (1)

HSP (1)

Influenza Virus (1)

Leukotriene Receptor (1)

Lipoxygenase (5)

Mitochondrial Metabolism (1)

Mitophagy (1)

Na+/H+ Exchanger (NHE) (3)

NF-κB (2)

NOD-like Receptor (NLR) (2)

Oxidative Phosphorylation (5)

Parasite (14)

Phospholipase (1)

PKC (2)

Potassium Channel (3)

Proton Pump (2)

Pyroptosis (1)

Reactive Oxygen Species (1)

Sodium Channel (2)

Wnt (8)

β-catenin (5)

By Research Areas:

Cancer (25)

Cardiovascular Disease (2)

Endocrinology (1)

Infection (30)

Inflammation/Immunology (10)

Metabolic Disease (3)

Neurological Disease (3)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1071

Lasalocid 2 Publications Verification Lasalocid-A; ionophore X-537A; Antibiotic X-537A	Bacterial Autophagy Antibiotic Parasite	Infection Cancer
Lasalocid (Lasalocid-A; Ionophore X-537A; Antibiotic X-537A) is an antibacterial and anticoccidial agent used in feed additives.

HY-B1071A

Lasalocid sodium 2 Publications Verification Lasalocid-A sodium; ionophore X-537A sodium; Antibiotic X-537A sodium	Bacterial Autophagy Antibiotic Parasite	Infection Cancer
Lasalocid sodium (Lasalocid-A sodium) is an antibacterial agent.

HY-136460

*Calcium ionophore* I** ETH 1001	Calcium Channel	Others
Calcium ionophore I (ETH 1001) is a selective Ca ²⁺ ionophore for biological membranes. Calcium ionophore I can be used in Ca2+-selective microelectrodes that can be used for quantitative intracellular measurements of resting Ca2+-activities and of slowly changing Ca2+-levels .

HY-101109

*Sodium ionophore* III** ETH2120	Sodium Channel	Cardiovascular Disease
Sodium ionophore III (ETH2120) is a Na ⁺ ionophore suitable for the assay of sodium activity in blood, plasma, serum. etc.

HY-D1896

*Chloride Ionophore* IV**	Fluorescent Dye	Others
Chloride Ionophore IV is a thiourea type hydrogen bonding-based receptor. Chloride Ionophore IV is a chloride ionophore .

HY-155254

*Sodium ionophore* VI**	Others	Others
Sodium ionophore VI is a sodium ionophore that has been employed for developing cation optical sensors .

HY-W783917

*Lead Ionophore* IV**	Others
Lead Ionophore IV is an ionophore that has the activity of promoting metal ion transport. Lead Ionophore IV is often used in biological research to study the biological effects of lead ions and their effects on cell function. Lead Ionophore IV can also be used to develop drug delivery systems to improve the bioavailability of compounds.

HY-137980

*Carbonate ionophore* VII**	Others	Others
Carbonate ionophore VII is primarily utilized in the fabrication of ion-selective electrodes.

HY-49457

*Copper(II) ionophore* I**	Others	Others
Copper(II) ionophore I is an active compound.

HY-W783680

*Potassium ionophore* III**	Potassium Channel	Others
Potassium ionophore III (BME-44) is a specific potassium ion carrier with high selectivity for sodium and ammonium ions and high lipophilicity .

HY-W923366

*Magnesium ionophore* III** ETH 4030	Others
Magnesium ionophore III (ETH 4030) is an ionophore that has the activity of regulating the intracellular magnesium concentration. Magnesium ionophore III can promote the permeability of cell membranes to magnesium ions and enhance cell functions and metabolic activities. Magnesium ionophore III is also used to study the importance of magnesium ions in biological processes and its effects on cell physiology.

HY-W020249

*Sodium ionophore* X**	Others	Others
Sodium ionophore X, a substituted calixarene, exhibits remarkably high ionophoric properties for metal ions and serves as a synergistic agent in the solvent extraction of lanthanoids alongside a thenoyltrifluoroacetone compound. Additionally, it plays a crucial role in the preparation of potentiometric membranes.

HY-139728

N,N,N′,N′-Tetracyclohexyl-3-oxapentanediamide Calcium ionophore II	Others	Others
N,N,N′,N′-Tetracyclohexyl-3-oxapentanediamide (Calcium ionophore II) is a lipophilic ionophore that can be used in preparing calcium ion-selective electrode .

HY-W674112

*Magnesium ionophore* I** ETH 1117	Others	Others
Magnesium ionophore I (ETH 1117) serves as the primary component for the development of calcium-magnesium selective electrodes.

HY-N6790

Nonactin Ammonium ionophore I	Oxidative Phosphorylation Potassium Channel Mitochondrial Metabolism Bacterial Influenza Virus Apoptosis Antibiotic HSP	Infection Cancer
Nonactin is a naturally occurring macrotetrolide antibiotic from Streptomyces griseus. Nonactin acts as an ionophore for monovalent cations, including K ⁺, and NH₄ ⁺ . Nonactin is able to uncouple the oxidative phosphorylation (OXPHOS) of mitochondria. Nonactin selectively induces apoptosis in cell lines harboring active mutant β-catenin . Nonactin inhibits the surface expression of endogenous HSP60 .

HY-120539

Enofelast BI-L-239	Lipoxygenase Leukotriene Receptor	Inflammation/Immunology
Enofelast (BI-L-239), a 5-lipoxygenase (5-LO) inhibitor, exhibits an IC₅₀ of 2.48 μM for inhibition of calcium ionophore-induced LTB₄ generation .

HY-135102

Laidlomycin propionate potassium	Biochemical Assay Reagents	Others
Laidlomycin propionate potassium is a semi-synthetic ionophore, which can be used as a feed additive for cattle to improve the rate of gain and feed conversion efficiency .

HY-111525

Monactin	Oxidative Phosphorylation Bacterial Antibiotic	Infection
Monactin is a mactrotetralide antibiotic and a non-selective ionophore for monovalent cations, including potassium, sodium, and lithium. Monactin is isolated from Streptomyces and has antiproliferative activity .

HY-121410

Narasin	Bacterial Apoptosis Parasite NF-κB Antibiotic	Infection Cancer
Narasin is a cationic ionophore and coccidiostat agent. Narasin inhibits NF-κB signaling and induces tumor cells apoptosis. Narasin has antimicrobial and anticancer activity .

HY-13434

Ionomycin 60+ Cited Publications SQ23377	Calcium Channel PKC Bacterial Apoptosis Antibiotic	Infection Cancer
Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC) .

HY-13434A

Ionomycin calcium 60+ Cited Publications SQ23377 calcium	Calcium Channel PKC Bacterial Apoptosis Antibiotic	Infection Cancer
Ionomycin calcium (SQ23377 calcium) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin calcium (SQ23377 calcium) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin calcium (SQ23377 calcium) also induces the activation of protein kinase C (PKC) .

HY-12361

PF 1022A 1 Publications Verification	Parasite	Infection
PF 1022A is a cyclooctadepsipeptide with broadspectrum anthelmintic properties produced by fermentation of the fungus Mycelia sterilia. PF 1022A is a channel-forming ionophore. PF 1022A showes strong anthelmintic activities against *Ascaridia galli* in chickens. PF 1022A also can be used for angiostrongyliasis research .

HY-N4302

Monensin Monensin A	Bacterial Apoptosis Antibiotic Parasite Na+/H+ Exchanger (NHE) Fungal Wnt	Infection Cancer
Monensin (Monensin A), an orally active antibiotic, is an ionophore that mediates Na ⁺/H ⁺ exchange. Monensin is a potent Wnt signaling inhibitor. Monensin causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion. Monensin can be used for bacterial, fungal, and parasitic infections research, and shows anticancer effects .

HY-105321A

PBT 1033 hydrochloride PBT 2 hydrochloride	Bacterial	Neurological Disease
PBT 1033 hydrochloride is an orally active copper/zinc ionophore. PBT 1033 hydrochloride restores cognition in mouse models of Alzheimer's disease (AD). PB 1033 also has antibacterial activity against Gram-positive bacteria .

HY-105321

PBT 1033 PBT 2	Bacterial	Neurological Disease
PBT 1033 (PBT 2) is an orally active copper/zinc ionophore. PBT 1033 restores cognition in mouse models of Alzheimer's disease (AD). PB 1033 also has antibacterial activity against Gram-positive bacteria .

HY-N6687

Calcimycin 5+ Cited Publications A-23187; Antibiotic A-23187	Oxidative Phosphorylation Bacterial Fungal Apoptosis Autophagy Antibiotic	Infection Cancer
Calcimycin (A-23187) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin induces Ca ²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin induces apoptosis .

HY-N6687B

Calcimycin hemimagnesium A-23187 hemimagnesium; Antibiotic A-23187 hemimagnesium	Oxidative Phosphorylation Bacterial Fungal Apoptosis Autophagy	Infection Cancer
Calcimycin (A-23187) hemimagnesium is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemimagnesium induces Ca ²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemimagnesium inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemimagnesium also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemimagnesium induces apoptosis .

HY-N6687A

Calcimycin hemicalcium salt A-23187 hemicalcium salt; Antibiotic A-23187 hemicalcium salt	Oxidative Phosphorylation Bacterial Fungal Apoptosis Autophagy Antibiotic	Infection Cancer
Calcimycin hemicalcium salt (A-23187 hemicalcium salt) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemicalcium salt induces Ca ²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemicalcium salt inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemicalcium salt also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemicalcium salt induces apoptosis .

HY-15597

Salinomycin 30+ Cited Publications Procoxacin	Bacterial Wnt β-catenin Mitophagy Autophagy Apoptosis Antibiotic Parasite	Cancer
Salinomycin (Procoxacin), a polyether potassium ionophore antibiotic, selectively inhibits the growth of gram-positive bacteria. Salinomycin is a potent inhibitor of Wnt/β-catenin signaling, blocks Wnt-induced LRP6 phosphorylation. Salinomycin (Procoxacin) shows selective activity against human cancer stem cells .

HY-121333

Dinactin	Antibiotic Wnt β-catenin	Infection Neurological Disease Cancer
Dinactin, an antibiotic ionophore produced by Streptomyces species, as an effective small molecule targeting Wnt/β-catenin signaling pathway in cancer cells. Dinactin shows marked inhibition of HCT-116 cell growth with an IC₅₀ of 1.1 µM. Dinactin shows anti-proliferative activity against the cancer cells in apoptosis-independent manner. Dinactin is also an effective agent for the research of neuropathic pain .

HY-100381

Nigericin sodium salt Maximum Cited Publications 119 Publications Verification	Potassium Channel NOD-like Receptor (NLR) Bacterial Antibiotic	Infection Cancer
Nigericin sodium salt is an antibiotic from Streptomyces hygroscopicus that works by acting as an H ⁺, K ⁺, and Pb ²⁺ ionophore, a NLRP3 activator .

HY-125703

Ferutinin	Estrogen Receptor/ERR Apoptosis	Infection Inflammation/Immunology Endocrinology Cancer
Ferutinin, a natural terpenoid compound, is an estrogen receptor ERα agonist and estrogen ERβ-receptor agonist/antagonist with IC₅₀s of 33.1 nM and 180.5 nM, respectively. Ferutinin acts as an electrogenic Ca ²⁺-ionophore that increases calcium permeability of lipid bilayer membranes, mitochondria. Ferutinin possesses estrogenic, antitumor, antibacterial and antiinflammatory activities .

HY-12040

Elesclomol 40+ Cited Publications STA-4783	Reactive Oxygen Species Apoptosis Cuproptosis	Cancer
Elesclomol (STA-4783) is a potent copper ionophore and promotes copper-dependent cell death (cuproptosis). Elesclomol specifically binds ferredoxin 1 (FDX1) α2/α3 helices and β5 strand. Elesclomol inhibits FDX1-mediated Fe-S cluster biosynthesis. Elesclomol is an oxidative stress inducer that induces cancer cell apoptosis. Elesclomol is a reactive oxygen species (ROS) inducer. Elesclomol can be used for Menkes and associated disorders of hereditary copper deficiency research .

HY-112225

Narasin sodium	Antibiotic Bacterial Parasite NF-κB Apoptosis	Infection Cancer
Narasin sodium is a cationic ionophore and coccidiostat agent. Narasin inhibits NF-κB signaling and induces tumor cells apoptosis. Narasin sodium has antimicrobial and anticancer activity .

HY-B1327S

Chlortetracycline-d6 hydrochloride 7-Chlorotetracycline-d₆ hydrochloride	Bacterial Antibiotic	Infection
Chlortetracycline-d₆ (hydrochloride) is the deuterium labeled Chlortetracycline hydrochloride. Chlortetracycline hydrochloride (7-Chlorotetracycline hydrochloride) is a specific and potent calcium ionophore antibiotic, inhibits binding of aminoacyl-tRNA to ribosomes.

HY-B1747

Pyrithione 3 Publications Verification	Bacterial Fungal	Infection
Pyrithione, a Transition metal complexe, is a zinc ionophore that causes increased zinc levels within mammalian cells. Pyrithione has potent bactericidal and anti-fungal activity .

HY-B1327R

Chlortetracycline hydrochloride (Standard)	Bacterial Antibiotic Parasite	Infection Inflammation/Immunology
Chlortetracycline (hydrochloride) (Standard) is the analytical standard of Chlortetracycline (hydrochloride). This product is intended for research and analytical applications. Chlortetracycline hydrochloride (7-Chlorotetracycline hydrochloride) is a specific and potent calcium ionophore antibiotic that inhibits the binding of aminoacyl-tRNA to ribosomes.

HY-B0572

Zinc Pyrithione 5+ Cited Publications	Cuproptosis Proton Pump Bacterial Fungal	Infection Metabolic Disease
Zinc Pyrithione is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump . Zinc Pyrithione is also a copper ionophore that delivers copper into cells and is a useful tool for studying cuproptosis .

HY-10437A

Setileuton tosylate MK-0633 tosylate	Lipoxygenase	Inflammation/Immunology
Setileuton tosylate is an inhibitor for 5-lipoxygenase, that inhibits the oxidation of arachidonic acid by recombinant human 5-LO, and the production of LTB4 in calcium ionophore-stimulated human whole blood, with IC₅₀ of 3.9 and 52 nM, respectively .

HY-N6694

4-Bromo A23187	Calcium Channel Bacterial Apoptosis Antibiotic	Infection Cancer
4-Bromo A23187 is a halogenated analog of the highly selective calcium ionophore A-23187. 4-Bromo A23187, a calcium modulator, induces apoptosis in different cells, including HL-60 cells .

HY-10437

Setileuton MK-0633	Lipoxygenase	Inflammation/Immunology
Setileuton (MK-0633) is an inhibitor for 5-lipoxygenase, that inhibits the oxidation of arachidonic acid by recombinant human 5-LO, and the production of LTB4 in calcium ionophore-stimulated human whole blood, with IC₅₀ of 3.9 and 52 nM, respectively .

HY-123103

Linetastine	Lipoxygenase Histamine Receptor	Inflammation/Immunology
Linetastine is an orally active and potent 5-Lipoxygenase inhibitor. Linetastine shows antihistamine activity. Linetastine inhibits leukotriene production and antagonizes the effect of histamine. Linetastine inhibits the release of leukotrienes B4 and C4 from calcium ionophore-stimulated human leukocytes .

HY-N1204

Soyacerebroside II	Others	Others
Soyacerebroside II is a calcium ionophoretic sphingoglycolipid that can be isolated from Soybean .

HY-B1327

Chlortetracycline hydrochloride 3 Publications Verification 7-Chlorotetracycline hydrochloride	Bacterial Antibiotic Parasite	Infection Inflammation/Immunology
Chlortetracycline hydrochloride (7-Chlorotetracycline hydrochloride) is an orally active, effective and selectively methanogenic bacteria inhibitor with bactericidal effects. Chlortetracycline hydrochloride is also a antibiotic that acts by inhibiting bacterial protein synthesis. Additionally, Chlortetracycline hydrochloride is a specific and potent calcium ionophore antibiotic, inhibiting binding of aminoacyl-tRNA to ribosomes .

HY-B1327A

Chlortetracycline 7-Chlorotetracycline	Bacterial Antibiotic Parasite	Infection Inflammation/Immunology
Chlortetracycline (7-Chlorotetracycline) is an orally active, effective and selectively methanogenic bacteria inhibitor with bactericidal effects. Chlortetracycline is also a antibiotic that acts by inhibiting bacterial protein synthesis. Additionally, Chlortetracycline is a specific and potent calcium ionophore antibiotic, inhibiting binding of aminoacyl-tRNA to ribosomes .

HY-106200

CJ-13,610	Lipoxygenase	Inflammation/Immunology
CJ-13,610, a nonredox-type 5-LO inhibitor, dose dependently suppresses 5-LO product formation in ionophore A23187-stimulated PMNL in the absence of exogenous AA with an IC₅₀ of about 70 nM . PMNL: polymorphonuclear leukocytes; AA: arachidonic acid

HY-B0572R

Zinc Pyrithione (Standard)	Cuproptosis Proton Pump Bacterial Fungal	Infection Metabolic Disease
Zinc Pyrithione (Standard) is the analytical standard of Zinc Pyrithione. This product is intended for research and analytical applications. Zinc Pyrithione is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump . Zinc Pyrithione is also a copper ionophore that delivers copper into cells and is a useful tool for studying cuproptosis .

HY-145473

1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE 15(S)-HETE-SAPE; 15(S)-Hydroxyeicosatetraenoic acid-SAPE; 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-Phosphatidylethanolamine	Others	Metabolic Disease
1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE is a phospholipid that contains stearic acid (HY-B2219) at the sn-1 position and 15(S)-HETE at the sn-2 position. It is formed in human peripheral monocytes activated by the calcium ionophore A23187 (HY-N6687) by direct oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PE (SAPE) by 15-LO. Phosphoethanolamine (PE) HETEs (PE-HETEs), including 1-stearoyl-2-15(S)-HETE-sn-glycero-3-PE, are the main source of esterified HETE in ionophore-activated monocytes.

HY-P2324

Gramicidin A 1 Publications Verification	Bacterial HIF/HIF Prolyl-Hydroxylase Antibiotic	Infection Cancer
Gramicidin A is a peptide component of gramicidin, an antibiotic mixture originally isolated from B. brevis. Gramicidin A is a highly hydrophobic channel-forming ionophore that forms channels in model membranes that are permeable to monovalent cations. Gramicidin A induces degradation of hypoxia inducible factor 1 α (HIF-1α) .

HY-162386

UM4118	Cuproptosis	Cancer
UM4118 is a copper ionophore that can initiate a mitochondrial-based noncanonical form of cell death known as cuproptosis. UM4118 exhibits high sensitivity in SF3B1-mutated and adverse risk acute myeloid leukemia (AML), and can be used for AML research .

Cat. No.	Product Name	Target	Research Area