N,N,N′,N′-Tetracyclohexyl-3-oxapentanediamide (Synonyms: Calcium ionophore II)

Name: N,N,N′,N′-Tetracyclohexyl-3-oxapentanediamide
Brand: MedChemExpress
SKU: HY-139728
Rating: 4.5 (1 reviews)

Cat. No.: HY-139728 Purity: 98.07%: FAQs
Data Sheet SDS COA Handling Instructions

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N,N,N′,N′-Tetracyclohexyl-3-oxapentanediamide (Calcium ionophore II) is a lipophilic ionophore that can be used in preparing calcium ion-selective electrode.

For research use only. We do not sell to patients.

N,N,N′,N′-Tetracyclohexyl-3-oxapentanediamide Chemical Structure

CAS No. : 74267-27-9

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Based on 1 publication(s) in Google Scholar

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Description

N,N,N′,N′-Tetracyclohexyl-3-oxapentanediamide (Calcium ionophore II) is a lipophilic ionophore that can be used in preparing calcium ion-selective electrode^[1].

In Vitro

Calcium ion-selective electrode can be used to measure the intracellular free calcium^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

460.69

Formula

C₂₈H₄₈N₂O₃

CAS No.

74267-27-9

Appearance

Solid

Color

White to off-white

SMILES

O=C(COCC(N(C1CCCCC1)C2CCCCC2)=O)N(C3CCCCC3)C4CCCCC4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 2.94 mg/mL (6.38 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1707 mL	10.8533 mL	21.7066 mL
5 mM	0.4341 mL	2.1707 mL	4.3413 mL
10 mM	---	---	---

View the Complete Stock Solution Preparation Table

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 0.29 mg/mL (0.63 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 0.29 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (2.9 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 0.29 mg/mL (0.63 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 0.29 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (2.9 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 0.29 mg/mL (0.63 mM); Clear solution

This protocol yields a clear solution of ≥ 0.29 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (2.9 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.05%

Select Batch:

Data Sheet (271 KB) SDS (393 KB)

COA (248 KB) HNMR (237 KB) RP-HPLC (256 KB) LCMS (88 KB)

Handling Instructions (2659 KB)

References

[1]. Ma YL, et, al. A study of calcium ion-selective PVC membrane electrode based on neutral carrier N,n,n',n'-tetracyclo-3-oxapentanediamide (correction of oxapetanediamide). J Tongji Med Univ. 1992;12(2):98-102. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1707 mL	10.8533 mL	21.7066 mL	54.2664 mL
DMSO	5 mM	0.4341 mL	2.1707 mL	4.3413 mL	10.8533 mL

N,N,N′,N′-Tetracyclohexyl-3-oxapentanediamide Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N,N,N′,N′-Tetracyclohexyl-3-oxapentanediamide74267-27-9Calcium ionophore IIOthersInhibitorinhibitorinhibit

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N,N,N′,N′-Tetracyclohexyl-3-oxapentanediamide (Synonyms: Calcium ionophore II)

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Complete Stock Solution Preparation Table

N,N,N′,N′-Tetracyclohexyl-3-oxapentanediamide Related Classifications

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