2. Anti-infection
  3. Bacterial Antibiotic Parasite
  4. Chlortetracycline hydrochloride

Chlortetracycline hydrochloride  (Synonyms: 7-Chlorotetracycline hydrochloride)

Cat. No.: HY-B1327 Purity: ≥95.0%
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Chlortetracycline hydrochloride (7-Chlorotetracycline hydrochloride) is an orally active, effective and selectively methanogenic bacteria inhibitor with bactericidal effects. Chlortetracycline hydrochloride is also a antibiotic that acts by inhibiting bacterial protein synthesis. Additionally, Chlortetracycline hydrochloride is a specific and potent calcium ionophore antibiotic, inhibiting binding of aminoacyl-tRNA to ribosomes.

For research use only. We do not sell to patients.

Chlortetracycline hydrochloride Chemical Structure

Chlortetracycline hydrochloride Chemical Structure

CAS No. : 64-72-2

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Solution
10 mM * 1 mL in Water USD 28 In-stock
Solid
1 g USD 25 In-stock
5 g USD 40 In-stock
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Based on 3 publication(s) in Google Scholar

Other Forms of Chlortetracycline hydrochloride:

Chlortetracycline hydrochloride Related Antibodies

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Description

Chlortetracycline hydrochloride (7-Chlorotetracycline hydrochloride) is an orally active, effective and selectively methanogenic bacteria inhibitor with bactericidal effects. Chlortetracycline hydrochloride is also a antibiotic that acts by inhibiting bacterial protein synthesis. Additionally, Chlortetracycline hydrochloride is a specific and potent calcium ionophore antibiotic, inhibiting binding of aminoacyl-tRNA to ribosomes[1][2][3][4].

IC50 & Target

Tetracycline

 

In Vitro

Chlortetracycline hydrochloride (10, 50, 100, 200 mg/L, 18 days) inhibits methane (a main component of biogas) production and is degradated and metabolized by anaerobic digestion (AD) at high concentrations and incubation temperatures[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chlortetracycline hydrochloride Related Antibodies
In Vivo

Chlortetracycline hydrochloride (50 mg/kg, p.o., administration for 42 consecutive days) significantly increases the IgM antibody levels and decreases the IgA antibody levels in serum of mice[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SPF level Kunming mice (KM)[4]
Dosage: 50 mg/kg
Administration: p.o., administration for 42 consecutive days
Result: Significantly increased the IgM antibody levels, decreased the IgA antibody levels and not influenced IgG antibody levels in serum of mice.
Molecular Weight

515.34

Formula

C22H24Cl2N2O8
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C(C1=O)=C(O)[C@@H](N(C)C)[C@]2([H])C[C@]3([H])[C@](C)(O)C4=C(C(C3=C(O)[C@@]21O)=O)C(O)=CC=C4Cl)N.[H]Cl
Structure Classification
Initial Source

Streptomyces aureofaciens
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 5 mg/mL (9.70 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9405 mL 9.7023 mL 19.4047 mL
5 mM 0.3881 mL 1.9405 mL 3.8809 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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Animal weight
(per animal)

g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥95.0%

SDS (393 KB)

COA (257 KB) HNMR (305 KB) MS (69 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.9405 mL 9.7023 mL 19.4047 mL 48.5117 mL
5 mM 0.3881 mL 1.9405 mL 3.8809 mL 9.7023 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Chlortetracycline hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chlortetracycline64-72-27-ChlorotetracyclineBacterialAntibioticParasiteorally activemethanogenic bacteria inhibitorbactericidal effectsantibioticribosomesInhibitorinhibitorinhibit

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