2. Membrane Transporter/Ion Channel Neuronal Signaling Anti-infection Apoptosis
  3. Calcium Channel Bacterial Apoptosis Antibiotic
  4. 4-Bromo A23187

4-Bromo A23187 is a halogenated analog of the highly selective calcium ionophore A-23187. 4-Bromo A23187, a calcium modulator, induces apoptosis in different cells, including HL-60 cells.

For research use only. We do not sell to patients.

4-Bromo A23187 Chemical Structure

4-Bromo A23187 Chemical Structure

CAS No. : 76455-48-6

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Based on 1 publication(s) in Google Scholar

4-Bromo A23187 Related Antibodies

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Description

4-Bromo A23187 is a halogenated analog of the highly selective calcium ionophore A-23187. 4-Bromo A23187, a calcium modulator, induces apoptosis in different cells, including HL-60 cells[1].

Molecular Weight

602.52

Formula

C29H36BrN3O6
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

C[C@H]1[C@@]2(O[C@@H]([C@@H](CC2)C)CC3=NC4=C(C(O)=O)C(NC)=C(Br)C=C4O3)O[C@]([C@@H](C1)C)([H])[C@H](C)C(C5=CC=CN5)=O
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (165.97 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6597 mL 8.2985 mL 16.5970 mL
5 mM 0.3319 mL 1.6597 mL 3.3194 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

SDS (251 KB)

COA (252 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6597 mL 8.2985 mL 16.5970 mL 41.4924 mL
5 mM 0.3319 mL 1.6597 mL 3.3194 mL 8.2985 mL
10 mM 0.1660 mL 0.8298 mL 1.6597 mL 4.1492 mL
15 mM 0.1106 mL 0.5532 mL 1.1065 mL 2.7662 mL
20 mM 0.0830 mL 0.4149 mL 0.8298 mL 2.0746 mL
25 mM 0.0664 mL 0.3319 mL 0.6639 mL 1.6597 mL
30 mM 0.0553 mL 0.2766 mL 0.5532 mL 1.3831 mL
40 mM 0.0415 mL 0.2075 mL 0.4149 mL 1.0373 mL
50 mM 0.0332 mL 0.1660 mL 0.3319 mL 0.8298 mL
60 mM 0.0277 mL 0.1383 mL 0.2766 mL 0.6915 mL
80 mM 0.0207 mL 0.1037 mL 0.2075 mL 0.5187 mL
100 mM 0.0166 mL 0.0830 mL 0.1660 mL 0.4149 mL
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4-Bromo A23187 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-Bromo A2318776455-48-6Calcium ChannelBacterialApoptosisAntibioticCa2+ channelsCa channelsInhibitorinhibitorinhibit

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