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longevity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (2) AMPK (1) Amyloid-β (2) Apoptosis (2) Fungal (2) GLUT (1) Insecticide (1) Isotope-Labeled Compounds (1) NF-κB (2) Parasite (2) Proteasome (2)
By Research Areas:	Cancer (3) Cardiovascular Disease (2) Infection (3) Inflammation/Immunology (3) Metabolic Disease (2) Neurological Disease (5)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-133968

24-Methylenecholesterol Ostreasterol	Acyltransferase	Inflammation/Immunology
24-Methylenecholesterol (Ostreasterol), a natural marine sterol, stimulates cholesterol acyltransferase in human macrophages. 24-Methylenecholesterol possess anti-aging effects in yeast. 24-methylenecholesterol enhances honey bee longevity and improves nurse bee physiology .

HY-P2048A

MOTS-c(human) acetate	AMPK GLUT	Metabolic Disease
MOTS-c(human) acetate is a mitochondrial-derived peptide. MOTS-c(human) acetate induces the accumulation of AMP analog AICAR, increases activation of AMPK and expression of its downstream GLUT4. MOTS-c(human) acetate induces glucose uptake and improves insulin sensitivity. MOTS-c(human) acetate has implications in the regulation of obesity, diabetes, exercise, and longevity .

HY-119902

Bistrifluron	Insecticide	Cardiovascular Disease
Bistrifluron has insecticidal effects on the larval stage, and also has an effect on adult longevity, reproduction, and hatchability. Bistrifluron is used for the control of a variety of Lepidopterous pests .

HY-135258

Galactinol dihydrate	Others	Others
Galactinol dihydrate is a marker for seed longevity. Galactinol dihydrate can scavenge hydroxyl radicals and protect plant cells from oxidative damage caused by MV treatment, salinity, or chilling .

HY-N0375

18α-Glycyrrhetinic acid	Proteasome NF-κB Apoptosis	Neurological Disease Inflammation/Immunology Cancer
18α-Glycyrrhetinic acid, a diet-derived compound, is an inhibitor of NF-kB and an activator of proteasome, which serves as pro-longevity and anti-aggregation factor in a multicellular organism. 18α-Glycyrrhetinic acid induces apoptosis .

HY-130221

(25S)-Δ7-Dafachronic acid Dafachronic acid A; Δ7-Dafachronic acid	Others	Others
(25S)-Δ7-Dafachronic acid is a ligand and activator of DAF-12 receptor. DAF-12 is a nuclear hormone receptor that regulates larval diapause, developmental age, and adult longevity in Caenorhabditis elegans .

HY-N12360

2,3-Dehydrosilybin A	Amyloid-β	Neurological Disease
2,3-Dehydrosilybin A is a pro-longevity and anti-aggregation compound .

HY-N12360R

2,3-Dehydrosilybin A (Standard)	Amyloid-β	Neurological Disease
2,3-Dehydrosilybin A (Standard) is the analytical standard of 2,3-Dehydrosilybin A. This product is intended for research and analytical applications. 2,3-Dehydrosilybin A is a pro-longevity and anti-aggregation compound .

HY-119902R

Bistrifluron (Standard)	Others	Cardiovascular Disease
Bistrifluron (Standard) is the analytical standard of Bistrifluron. This product is intended for research and analytical applications. Bistrifluron has insecticidal effects on the larval stage, and also has an effect on adult longevity, reproduction, and hatchability. Bistrifluron is used for the control of a variety of Lepidopterous pests .

HY-N12526

Isolappaol A	Others	Others
Isolappaol A is a natural product that can be isolated from the Arctium lappa. Isolappaol A upregulates the expression of jnk-1, which may promote longevity and stress resistance of C. elegans through the JNK-1-DAF-16 cascade .

HY-N0375R

18α-Glycyrrhetinic acid (Standard)	Proteasome NF-κB Apoptosis	Neurological Disease Inflammation/Immunology Cancer
18α-Glycyrrhetinic acid (Standard) is the analytical standard of 18α-Glycyrrhetinic acid. This product is intended for research and analytical applications. 18α-Glycyrrhetinic acid, a diet-derived compound, is an inhibitor of NF-kB and an activator of proteasome, which serves as pro-longevity and anti-aggregation factor in a multicellular organism. 18α-Glycyrrhetinic acid induces apoptosis .

HY-W020182

α-Terpinene Terpilene	Fungal Parasite	Infection
α-Terpinene (Terpilene) is a monoterpene found in the essential oils of a large variety of foods and aromatic plants such as Mentha piperita. α-Terpinene is active against *Trypanosoma evansi* and has the potential for trypanosomosis treatment. α-Terpinene has antioxidant and antifungal properties .

HY-W020182R

α-Terpinene (Standard)	Fungal Parasite	Infection
α-Terpinene (Standard) is the analytical standard of α-Terpinene. This product is intended for research and analytical applications. α-Terpinene (Terpilene) is a monoterpene found in the essential oils of a large variety of foods and aromatic plants such as Mentha piperita. α-Terpinene is active against Trypanosoma evansi and has the potential for trypanosomosis treatment. α-Terpinene has antioxidant and antifungal properties .

HY-133968S1

24-Methylenecholesterol-13C Ostreasterol-¹³C	Isotope-Labeled Compounds Acyltransferase	Others
24-Methylenecholesterol- ¹³C (Ostreasterol- ¹³C) is the ¹³C labeled 24-Methylenecholesterol (HY-133968) . 24-Methylenecholesterol (Ostreasterol), a natural marine sterol, stimulates cholesterol acyltransferase in human macrophages. 24-Methylenecholesterol possess anti-aging effects in yeast. 24-methylenecholesterol enhances honey bee longevity and improves nurse bee physiology .

HY-100072

(2E,4E,6Z)-Methyl deca-2,4,6-trienoate Methyl (2E,4E,6Z)-decatrienoate	Others	Infection
(2E,4E,6Z)-Methyl deca-2,4,6-trienoate (Methyl (2E,4E,6Z)-decatrienoate) is the aggregation pheromone of the brown-winged green bug, Plautia stali. (2E,4E,6Z)-Methyl deca-2,4,6-trienoate exposed to daylight in solutions and/or on dispensers used for field trapping can readily isomerize to form complex mixtures of isomers, thus causing a concern about lure stability and longevity .

HY-N12486A

(3S,8R,9R)-Isofalcarintriol	Others	Neurological Disease Metabolic Disease Cancer
(3S,8R,9R)-Isofalcarintriol is a natural polyacetylene compound found in carrot root parts. (3S,8R,9R)-Isofalcarintriol is a potent longevity promoter that improves glucose metabolism and has anti-tumor activity. (3S,8R,9R)-Isofalcarintriol can affect cellular respiration, interact with the α subunit of mitochondrial ATP synthase, and promote mitochondrial biogenesis. (3S,8R,9R)-Isofalcarintriol can be used in the study of neurodegenerative diseases, metabolic diseases, and aging .

Cat. No.	Product Name	Target	Research Area

HY-P2048A

MOTS-c(human) acetate	AMPK GLUT	Metabolic Disease
MOTS-c(human) acetate is a mitochondrial-derived peptide. MOTS-c(human) acetate induces the accumulation of AMP analog AICAR, increases activation of AMPK and expression of its downstream GLUT4. MOTS-c(human) acetate induces glucose uptake and improves insulin sensitivity. MOTS-c(human) acetate has implications in the regulation of obesity, diabetes, exercise, and longevity .

HY-P2048

MOTS-c (human)	Peptides	Others
MOTS-c (human) is a biological active peptide. (Recent advances in high-resolution sequencing have led to the discovery of unique peptides derived from mitochondrial genome.1-2 Currently 8 peptides are identified: humanin, mitochondrial open reading frame of the 12S tRNA-c (MOTS-c), and six small humanin-like peptides (SHLP1-6). 1-2 All of these peptides are released into cytosol from mitochondria and associate with increased longevity and cell viability, reduced apoptosis, and other beneficial functions. 1-3 MOTS-c was found to reduce insulin resistance, decrease obesity, and promote homeostasis.)

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-133968

24-Methylenecholesterol Ostreasterol	Structural Classification Classification of Application Fields Anti-aging Source classification Marine natural products Other marine organisms Plants other families Microorganisms Animals Inflammation/Immunology Disease Research Fields Steroids	Acyltransferase
24-Methylenecholesterol (Ostreasterol), a natural marine sterol, stimulates cholesterol acyltransferase in human macrophages. 24-Methylenecholesterol possess anti-aging effects in yeast. 24-methylenecholesterol enhances honey bee longevity and improves nurse bee physiology .

HY-N0375

18α-Glycyrrhetinic acid	Triterpenes Structural Classification Neurological Disease Classification of Application Fields Leguminosae Terpenoids Source classification Plants Glycyrrhiza uralensis Fisch. Inflammation/Immunology Disease Research Fields	Proteasome NF-κB Apoptosis
18α-Glycyrrhetinic acid, a diet-derived compound, is an inhibitor of NF-kB and an activator of proteasome, which serves as pro-longevity and anti-aggregation factor in a multicellular organism. 18α-Glycyrrhetinic acid induces apoptosis .

HY-W020182

α-Terpinene Terpilene	Infection Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields Biological Pesticide Research Agricultural Research	Fungal Parasite
α-Terpinene (Terpilene) is a monoterpene found in the essential oils of a large variety of foods and aromatic plants such as Mentha piperita. α-Terpinene is active against *Trypanosoma evansi* and has the potential for trypanosomosis treatment. α-Terpinene has antioxidant and antifungal properties .

HY-N12360

2,3-Dehydrosilybin A	Structural Classification Flavonols Flavonoids Source classification Cyamopsis tetragonoloba (L.) Taub. Plants Compositae	Amyloid-β
2,3-Dehydrosilybin A is a pro-longevity and anti-aggregation compound .

HY-N12360R

2,3-Dehydrosilybin A (Standard)	Structural Classification Flavonols Flavonoids Source classification Cyamopsis tetragonoloba (L.) Taub. Plants Compositae	Amyloid-β
2,3-Dehydrosilybin A (Standard) is the analytical standard of 2,3-Dehydrosilybin A. This product is intended for research and analytical applications. 2,3-Dehydrosilybin A is a pro-longevity and anti-aggregation compound .

HY-N12526

Isolappaol A	Structural Classification Source classification Lignans Phenols Polyphenols Phenylpropanoids Plants Compositae Caesalpinia magnifoliolata Metc.	Others
Isolappaol A is a natural product that can be isolated from the Arctium lappa. Isolappaol A upregulates the expression of jnk-1, which may promote longevity and stress resistance of C. elegans through the JNK-1-DAF-16 cascade .

HY-N0375R

18α-Glycyrrhetinic acid (Standard)	Triterpenes Structural Classification Leguminosae Terpenoids Source classification Plants Glycyrrhiza uralensis Fisch.	Proteasome NF-κB Apoptosis
18α-Glycyrrhetinic acid (Standard) is the analytical standard of 18α-Glycyrrhetinic acid. This product is intended for research and analytical applications. 18α-Glycyrrhetinic acid, a diet-derived compound, is an inhibitor of NF-kB and an activator of proteasome, which serves as pro-longevity and anti-aggregation factor in a multicellular organism. 18α-Glycyrrhetinic acid induces apoptosis .

HY-W020182R

α-Terpinene (Standard)	Structural Classification Natural Products other families Source classification Plants	Fungal Parasite
α-Terpinene (Standard) is the analytical standard of α-Terpinene. This product is intended for research and analytical applications. α-Terpinene (Terpilene) is a monoterpene found in the essential oils of a large variety of foods and aromatic plants such as Mentha piperita. α-Terpinene is active against Trypanosoma evansi and has the potential for trypanosomosis treatment. α-Terpinene has antioxidant and antifungal properties .

HY-N12486A

(3S,8R,9R)-Isofalcarintriol	Structural Classification Natural Products Source classification Umbelliferae Plants Mentha suaveolens Ehrh.	Others
(3S,8R,9R)-Isofalcarintriol is a natural polyacetylene compound found in carrot root parts. (3S,8R,9R)-Isofalcarintriol is a potent longevity promoter that improves glucose metabolism and has anti-tumor activity. (3S,8R,9R)-Isofalcarintriol can affect cellular respiration, interact with the α subunit of mitochondrial ATP synthase, and promote mitochondrial biogenesis. (3S,8R,9R)-Isofalcarintriol can be used in the study of neurodegenerative diseases, metabolic diseases, and aging .

Cat. No.	Product Name	Chemical Structure

HY-133968S1

24-Methylenecholesterol-13C
24-Methylenecholesterol- ¹³C (Ostreasterol- ¹³C) is the ¹³C labeled 24-Methylenecholesterol (HY-133968) . 24-Methylenecholesterol (Ostreasterol), a natural marine sterol, stimulates cholesterol acyltransferase in human macrophages. 24-Methylenecholesterol possess anti-aging effects in yeast. 24-methylenecholesterol enhances honey bee longevity and improves nurse bee physiology .

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longevity

Inhibitors & Agonists

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
Products