2,3-Dehydrosilybin A

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2,3-Dehydrosilybin A is a pro-longevity and anti-aggregation compound.

For research use only. We do not sell to patients.

2,3-Dehydrosilybin A Chemical Structure

CAS No. : 25166-14-7

Size	Stock	Quantity
1 mg	Get quote 3 - 4 weeks 4 - 5 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
5 mg	Get quote 3 - 4 weeks 4 - 5 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
10 mg	Get quote
50 mg	Get quote

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Other Forms of 2,3-Dehydrosilybin A:

2,3-Dehydrosilybin B Get quote
2,3-Dehydrosilybin A (Standard) Get quote

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Biological Activity
Purity & Documentation
References
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Description

2,3-Dehydrosilybin A is a pro-longevity and anti-aggregation compound^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	11.48 μM Compound: 2	Antiproliferative activity against human DU145 cells assessed as reduction in cell viability after 3 days by WST-1 assay Antiproliferative activity against human DU145 cells assessed as reduction in cell viability after 3 days by WST-1 assay	[PMID: 27261177]
HUVEC	IC₅₀	12 μM Compound: 1	Cytotoxicity in HUVEC assessed as reduction in cell viability measured after 24 hrs by MTT assay Cytotoxicity in HUVEC assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 27015547]
HUVEC	IC₅₀	12.2 μM Compound: 1	Antimigratory activity in HUVEC assessed as inhibition of cell migration measured after 16 to 20 hrs by crystal violet staining-based microscopic analysis Antimigratory activity in HUVEC assessed as inhibition of cell migration measured after 16 to 20 hrs by crystal violet staining-based microscopic analysis	[PMID: 27015547]
HUVEC	IC₅₀	5.4 μM Compound: 1	Antiproliferative activity in HUVEC assessed as reduction in cell viability measured after 72 hrs by MTT assay Antiproliferative activity in HUVEC assessed as reduction in cell viability measured after 72 hrs by MTT assay	[PMID: 27015547]
LNCaP	IC₅₀	3.09 μM Compound: 2	Antiproliferative activity against human LNCAP cells assessed as reduction in cell viability after 3 days by WST-1 assay Antiproliferative activity against human LNCAP cells assessed as reduction in cell viability after 3 days by WST-1 assay	[PMID: 27261177]
PC-12	EC₅₀	30.2 μM Compound: DHS	Neuroprotective activity against H2O2-induced injury in rat PC12 cells treated 2 hrs before H2O2 challenge measured after 4 hrs by MTT assay Neuroprotective activity against H2O2-induced injury in rat PC12 cells treated 2 hrs before H2O2 challenge measured after 4 hrs by MTT assay	[PMID: 19673490]
PC-3	IC₅₀	9.45 μM Compound: 2	Antiproliferative activity against human PC3 cells assessed as reduction in cell viability after 3 days by WST-1 assay Antiproliferative activity against human PC3 cells assessed as reduction in cell viability after 3 days by WST-1 assay	[PMID: 27261177]
Rat1	IC₅₀	155 μM Compound: DHS, enantiomeric mixture	Cytotoxicity against rat immortalized Rat1 cells after 48 hrs by MTT assay Cytotoxicity against rat immortalized Rat1 cells after 48 hrs by MTT assay	[PMID: 21737270]

In Vitro

2,3-dehydrosilybin A (DHS A) promotes lifespan extension in C. elegans^[1].
2,3-dehydrosilybin A promotes resistance to stress in human cells and in C. elegans^[1].
2,3-dehydrosilybin A exerts anti-aggregation properties in human cells and nematodes^[1].
2,3-dehydrosilybin A leads to decelerated progression of Alzheimer's disease phenotype^[1].
2,3-dehydrosilybin A outcomes in C. elegans are FGT-1- and DAF-16- dependent^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

480.42

Formula

C₂₅H₂₀O₁₀

CAS No.

25166-14-7

SMILES

OC[C@@H]1[C@@H](C2=CC(OC)=C(C=C2)O)OC3=CC(C(OC4=CC(O)=CC(O)=C45)=C(O)C5=O)=CC=C3O1

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Konstantina Filippopoulou, et al. 2,3-Dehydrosilybin A/B as a pro-longevity and anti-aggregation compound. Free Radic Biol Med. 2017 Feb:103:256-267. [Content Brief]