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Results for "

nematodes

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (6) Apoptosis (6) ATP Synthase (1) Autophagy (1) Bacterial (11) CDK (1) Chloride Channel (2) Cholinesterase (ChE) (2) Cytochrome P450 (2) Endogenous Metabolite (1) Fluorescent Dye (1) Fungal (5) Isotope-Labeled Compounds (1) Keap1-Nrf2 (1) Microtubule/Tubulin (2) Mitochondrial Metabolism (1) Monoamine Oxidase (1) nAChR (4) NF-κB (1) P-glycoprotein (2) Parasite (31) Tyrosinase (1) α-synuclein (1)
By Research Areas:	Cancer (10) Cardiovascular Disease (1) Infection (39) Inflammation/Immunology (2) Metabolic Disease (3) Neurological Disease (1)

By Targets:

Antibiotic (6)

Apoptosis (6)

ATP Synthase (1)

Autophagy (1)

Bacterial (11)

CDK (1)

Chloride Channel (2)

Cholinesterase (ChE) (2)

Cytochrome P450 (2)

Endogenous Metabolite (1)

Fluorescent Dye (1)

Fungal (5)

Isotope-Labeled Compounds (1)

Keap1-Nrf2 (1)

Microtubule/Tubulin (2)

Mitochondrial Metabolism (1)

Monoamine Oxidase (1)

nAChR (4)

NF-κB (1)

P-glycoprotein (2)

Parasite (31)

Tyrosinase (1)

α-synuclein (1)

By Research Areas:

Cancer (10)

Cardiovascular Disease (1)

Infection (39)

Inflammation/Immunology (2)

Metabolic Disease (3)

Neurological Disease (1)

Inhibitors & Agonists

Fluorescent Dye

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N8393

Ascr#18	Bacterial Fungal	Infection
Ascr#18, an ascaroside, is a hormone of nematodes. Ascr#18 is expressed during nematode development. Ascr#18 increases resistance in Arabidopsis, tomato, potato and barley to viral, bacterial, oomycete, fungal and nematode infections .

HY-N9441

Ascr#7	Others	Others
Ascr#7, an ascaroside, is a hormone of nematodes. Ascr#7 is expressed during nematode development. Ascarosides can induce formation of long-lived and highly stress resistant dauer larvae .

HY-116536

N-3-Oxo-tetradecanoyl-L-homoserine lactone oxo-C14-HSL	Bacterial	Infection
N-3-Oxo-tetradecanoyl-L-homoserine lactone (oxo-C14-HSL) is a rhizobacterial inducer and can improve basic defense against nematodes .

HY-D1275

CAY10731	Fluorescent Dye	Others
CAY10731 (compound 3) is a highly selective fluorescent probe for detection of hydrogen sulfide (H₂S). CAY10731 is used to monitor exo- and endogenous H₂S in both cancer and normal cells. CAY10731 is applied for imaging of H₂S in living tissues at variable depths and in nematodes .

HY-164342

Netobimin SCH 32481	Others	Infection
Netobimin is a dewormer that is effective against naturally acquired gastrointestinal nematodes in cows .

HY-122765

Luxabendazole HOE 216V	Parasite	Infection
Luxabendazole (HOE 216V) is an effective anthelmintic against trematodes, cestodes and nematodes .

HY-163804

Cyprocide-B	Cytochrome P450 Parasite	Others
Cyprocide-B is activated by Cytochrome P450 and converted to electrophilic metabolites that selectively kill nematodes C. elegans. Cyprocide-B is promising for research of selective nematicide .

HY-149810

AcrB-IN-2	Bacterial Parasite	Infection
AcrB-IN-2 is an AcrB efflux pump inhibitor, with ability to potentiate the effect of antibiotics. AcrB-IN-22 inhibits Nile Red (a known substrate of AcrB) efflux.AcrB-IN-2 does not disrupts the bacterial outer membrane nor display toxicity in a nematode model .

HY-149811

AcrB-IN-3	Bacterial Parasite	Infection
Efflux pump-IN-3 is an AcrB efflux pump inhibitor, with ability to potentiate the effect of antibiotics. Efflux pump-IN-3 inhibits Nile Red (a known substrate of AcrB) efflux. Efflux pump-IN-3 does not disrupts the bacterial outer membrane nor display toxicity in a nematode model .

HY-149812

AcrB-IN-4	Bacterial Parasite	Infection
Efflux pump-IN-4 is an AcrB efflux pump inhibitor, with ability to potentiate the effect of antibiotics. Efflux pump-IN-4 inhibits Nile Red (a known substrate of AcrB) efflux. Efflux pump-IN-4 does not disrupts the bacterial outer membrane nor display toxicity in a nematode model .

HY-157459

SDH-IN-11	Fungal	Infection
SDH-IN-11 (compound A7) is a SDH inhibitor, and shows inhibitory effect on nematode feeding, reproductive ability, and egg hatching. SDH-IN-11 promotes the oxidative stress of nematodes and causes intestinal damage to nematodes. SDH-IN-11 inhibits the activity of succinate dehydrogenase (SDH) in nematodes .

HY-107771

Fluensulfone MCW-2	Parasite	Cancer
Fluensulfone is a new nematicide for chemical control of plant parasitic nematodes.

HY-125159

Derquantel PF-00520904	Parasite	Infection
Derquantel is a potent anthelmintic. Derquantel causes flaccid paralysis and expulsion of nematodes .

HY-15308

Avermectin B1a Abamectin B1a	Parasite Antibiotic	Infection
Avermectin B1a is an antiparasitic agent that paralyzes nematodes without causing hypercontraction or flaccid paralysis.

HY-159080

HgCht2-IN-1	Parasite	Infection
HgCht2-IN-1 (compound 1516b) is a HgCht2 inhibitor that successfully inhibits the antagonism of cyst nematodes against nitrogen-fixing rhizobia and phosphate-absorbing arbuscular mycorrhizal symbionts. HgCht2-IN-1 can be used in the study of cyst nematode antagonism against microbial symbionts .

HY-N12722

Ophiocordylongiiside A	Others	Others
Ophiocordylongiiside A is a compound found in Polyphilus sieberi. Ophiocordylongiiside A shows activity against the free-living nematode Caenorhabditis elegans .

HY-14774

Monepantel AAD1566	nAChR	Cancer
Monepantel is organic anthelmintic, and acts as a positive allosteric modulator of a nematode-specific clade of nicotinic acetylcholine receptor (nAChR) subunits.

HY-N3754

Dihydropinosylvin monomethyl ether	Parasite	Infection
Dihydropinosylvin monomethyl ether is a natrual compound with nematicidal activity. Dihydropinosylvin monomethyl ether can inhibit pine wood nematodes infection .

HY-142025

Daumone	Others	Infection Metabolic Disease
Daumone is a natural product secreted by Caenorhabditis elegans. Daumone can be used for aging and obesity research and the development of anti-nematode drugs .

HY-P2779

Microsomal aminopeptidase, Microorganism	Endogenous Metabolite	Metabolic Disease
Microsomal aminopeptidase, Microorganism is first reported from C. elegans. The Microsomal aminopeptidase, Microorganism is beneficial for the development of molecular vaccines against parasitic nematodes .

HY-B0299

Oxibendazole 2 Publications Verification	Parasite Apoptosis	Infection
Oxibendazole is an effective benzimidazole anthelmintic and is against nema-tode infections. Oxibendazole can induces apoptosis and has anti-cancer and anti-inflammation activities .

HY-136240

Tioxazafen	Parasite	Infection
Tioxazafen is a disubstituted oxadiazole and a broad-spectrum seed treatment nematicide. Tioxazafen is designed to provide consistent broad-spectrum control of nematodes in corn, soy, and cotton .

HY-W035409

RPW-24 1 Publications Verification	Bacterial	Infection
RPW-24 protects C. elegans from bacterial infection by stimulating the host immune response of the nematode. RPW-24 has antibacterial activity .

HY-W020785

Fosthiazate	Cholinesterase (ChE)	Others
Fosthiazate is a broad-spectrum nematicide against various plant parasitic nematodes, including Meloidogyne spp., Globodera spp., and Pratylenchus spp., through inhibiting the synthesis of acetylcholinesterase .

HY-14774S

(Rac)-Monepantel-d5	nAChR	Cancer
(Rac)-Monepantel-d₅ is deuterium labeled Monepantel. Monepantel is organic anthelmintic, and acts as a positive allosteric modulator of a nematode-specific clade of nicotinic acetylcholine receptor (nAChR) subunits.

HY-137252

22,23-Dihydroavermectin B1a aglycon Ivermectin Impurity G	Parasite	Infection
22,23-Dihydroavermectin B1a aglycon is an acid degradation product produced by hydrolysis of the disaccharide unit of ivermectin. It can inhibit nematode larval development, but does not cause paralytic activity.

HY-17597

Febantel	Parasite	Infection
Febantel is an oral dewormer used to treat gastrointestinal nematodes in sheep, as well as roundworm and tapeworm infections in poultry and livestock, and it also inhibits the embryonic development of mouse hairworms and whipworm eggs .

HY-17595S1

Mebendazole-d8	Isotope-Labeled Compounds Parasite Apoptosis	Infection Cancer
Mebendazole-d₈ is the deuterium labeled Mebendazole. Mebendazole is a highly effective, broad-spectrum antihelmintic indicated for the treatment of nematode infestations; has been found as a hedgehog inhibitor .

HY-14774S1

(Rac)-Monepantel sulfone-d5	nAChR	Cancer
(Rac)-Monepantel sulfone-d₅ is deuterium labeled Monepantel. Monepantel is organic anthelmintic, and acts as a positive allosteric modulator of a nematode-specific clade of nicotinic acetylcholine receptor (nAChR) subunits.

HY-14774R

Monepantel (Standard)	nAChR	Cancer
Monepantel (Standard) is the analytical standard of Monepantel. This product is intended for research and analytical applications. Monepantel is organic anthelmintic, and acts as a positive allosteric modulator of a nematode-specific clade of nicotinic acetylcholine receptor (nAChR) subunits.

HY-148968

Metham sodium Carbathion	Fungal	Infection
Metham sodium (Carbathion) is a broad-spectrum soil microbial suppressant. Metham sodium controls soil-borne pests and weeds. Metham sodium inhibits weed seeds, plant-parasitic nematodes, plant pathogenic fungi and soil insects .

HY-134220

Doramectin monosaccharide	Parasite	Infection
Doramectin monosaccharide is an acid degradation product of Doramectin (HY-17035), a disaccharide-containing anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes. Doramectin undergoes acid-catalyzed hydrolysis to form doramectin monosaccharide.

HY-15308R

Avermectin B1a (Standard)	Parasite Antibiotic	Infection
Avermectin B1a (Standard) is the analytical standard of Avermectin B1a. This product is intended for research and analytical applications. Avermectin B1a is an antiparasitic agent that paralyzes nematodes without causing hypercontraction or flaccid paralysis.

HY-16670

Dafadine-A	Cytochrome P450	Others
Dafadine-A, an analog of dafadine, is a novel inhibitor of DAF-9 cytochrome P450 in the nematode Caenorhabditis elegans; also inhibits the mammalian ortholog of DAF-9(CYP27A1).

HY-118448

2,4-Diacetylphloroglucinol	Antibiotic Bacterial Fungal Parasite	Infection
2,4-Diacetylphloroglucinol, produced by some isolates of the beneficial bacterium Pseudomonas fluorescens, is a potent antibiotic. 2,4-Diacetylphloroglucinol is active against numerous organisms, including plants, fungi, viruses, bacteria, and nematodes .

HY-B0299R

Oxibendazole (Standard)	Parasite Apoptosis	Infection
Oxibendazole (Standard) is the analytical standard of Oxibendazole. This product is intended for research and analytical applications. Oxibendazole is an effective benzimidazole anthelmintic and is against nema-tode infections. Oxibendazole can induces apoptosis and has anti-cancer and anti-inflammation activities .

HY-W020785R

Fosthiazate (Standard)	Cholinesterase (ChE)	Others
Fosthiazate (Standard) is the analytical standard of Fosthiazate. This product is intended for research and analytical applications. Fosthiazate is a broad-spectrum nematicide against various plant parasitic nematodes, including Meloidogyne spp., Globodera spp., and Pratylenchus spp., through inhibiting the synthesis of acetylcholinesterase .

HY-17595

Mebendazole 3 Publications Verification	Parasite Apoptosis Microtubule/Tubulin	Infection Cancer
Mebendazole is a highly effective, broad-spectrum antihelmintic against nematode infestations. Mebendazole also exhibits inhibitory effect against glioblastoma multiforme (GBM), inhibits Hedgehog pathway and tubulin polymerization. Mebendazole is orally active and can cross CNS penetration .

HY-107212

Selamectin	Parasite Chloride Channel P-glycoprotein Bacterial	Infection
Selamectin, a semi-synthetic macrocyclic lactone, is a potent parasiticide and anthelminthic. Selamectin activates glutamate-gated chloride channels in neurons and pharyngeal muscles to prevent heartworm, *Lymphatic filariae, and nematode* infection. Selamectin is also a potent P-glycoprotein substrate and a P-glycoprotein inhibitor with an IC₅₀ of 120 nM .

HY-W011239

Fenbendazole sulfone Oxfendazole sulfone; FBZ-SO2	Parasite	Infection
Fenbendazole sulfone (Oxfendazole sulfone;FBZ-SO2) is a minor metabolite of Fenbendazole in plasma and is a benzimidazole anthelmintic agent .

HY-W011239R

Fenbendazole sulfone (Standard)	Parasite	Infection
Fenbendazole sulfone (Standard) is the analytical standard of Fenbendazole sulfone. This product is intended for research and analytical applications. Fenbendazole sulfone (Oxfendazole sulfone;FBZ-SO2) is a minor metabolite of Fenbendazole in plasma and is a benzimidazole anthelmintic agent .

HY-N6977

Ascr#3	Others	Infection
Ascr#3 is a type of pheromone found in the beautiful nematode, and when mixed with ascr#2, it can act as a male attractant and also induce the formation of dauer (the dormant larval stage). Ascr#3 can counteract the effects caused by male-enriched Ascr#10 .

HY-123693

ML358	Others	Inflammation/Immunology
ML358 is a first in class, potent, and selective inhibitor of the SKN-1 pathway (IC₅₀=0.24 μM). ML358 sensitizes the model nematode C. elegans to oxidants and anthelmintic. ML358 potentially used as adjuvants to increase the efficacy and useful life of current anthelmintics .

HY-158423

NPD8790	Mitochondrial Metabolism Parasite	Infection
NPD8790 is a species selective mitochondrial respiratory complex I inhibitor with an IC₅₀ of 2.4 µM for C. elegans complex I. NPD8790 is more selective for nematode species mitochondria than human, bovine, and mouse mitochondria. NPD8790 is an anthelmintic that kills adult soil-transmitted helminths .

HY-124902

Valclavam	Antibiotic Fungal Bacterial	Infection
Valclavam is an antibiotic, which exhibits antibacterial and antifungal activities. Valclavam inhibits homoserine-O-succinyltransferase (EC 2.3.1.46), blocks the methionine synthesis, and thus inhibits Escherichia coli. Valclavam inhibits Saccharomyces cerevisiae through inhibition of RNA formation. Valclavam inhibits the movement and reproduction of nematode Caenorhabditis elegans.

HY-B0778

Milbemycin oxime 1 Publications Verification	Antibiotic Parasite	Infection
Milbemycin oxime is an orally active macrolide with broad-spectrum antiparasitic activity. Milbemycin oxime is a mixture of oximes consisting of oxime derivatives corresponding to milbemycin A4 and A3. Milbemycin oxime binds to glutamate-gated chloride channels and has inhibitory potency against intestinal nematodes and lung/heart worms .

HY-17595R

Mebendazole (Standard)	Parasite Apoptosis Microtubule/Tubulin	Infection Cancer
Mebendazole (Standard) is the analytical standard of Mebendazole. This product is intended for research and analytical applications. Mebendazole is a highly effective, broad-spectrum antihelmintic against nematode infestations. Mebendazole also exhibits inhibitory effect against glioblastoma multiforme (GBM), inhibits Hedgehog pathway and tubulin polymerization. Mebendazole is orally active and can cross CNS penetration .

HY-12361

PF 1022A 1 Publications Verification	Parasite	Infection
PF 1022A is a cyclooctadepsipeptide with broadspectrum anthelmintic properties produced by fermentation of the fungus Mycelia sterilia. PF 1022A is a channel-forming ionophore. PF 1022A showes strong anthelmintic activities against *Ascaridia galli* in chickens. PF 1022A also can be used for angiostrongyliasis research .

HY-N12486

Isofalcarintriol	Keap1-Nrf2 ATP Synthase	Metabolic Disease
Isofalcarintriol is a NRF2 activator and selective inhibitor of the mitochondrial ATP synthase. Isofalcarintriol can be used for aging study .

HY-107212R

Selamectin (Standard)	Parasite Chloride Channel P-glycoprotein Bacterial	Infection
Selamectin (Standard) is the analytical standard of Selamectin. This product is intended for research and analytical applications. Selamectin, a semi-synthetic macrocyclic lactone, is a potent parasiticide and anthelminthic. Selamectin activates glutamate-gated chloride channels in neurons and pharyngeal muscles to prevent heartworm, *Lymphatic filariae, and nematode* infection. Selamectin is also a potent P-glycoprotein substrate and a P-glycoprotein inhibitor with an IC₅₀ of 120 nM .

Cat. No.	Product Name	Type