Cyprocide-B

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Cyprocide-B is activated by Cytochrome P450 and converted to electrophilic metabolites that selectively kill nematodes C. elegans. Cyprocide-B is promising for research of selective nematicide.

For research use only. We do not sell to patients.

Cyprocide-B Chemical Structure

CAS No. : 49809-25-8

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cyprocide-B is activated by Cytochrome P450 and converted to electrophilic metabolites that selectively kill nematodes C. elegans. Cyprocide-B is promising for research of selective nematicide^[1].

In Vitro

Cyprocide-B (50 µM, 3 days) is a selective nematicide with broad-spectrum activity in plant-parasitic nematodes (PPNs), and is safer for zebrafish than Tioxazafen (HY-136240)^[1].
Cyprocide-B (25 μM, 24 h) is bioactivated by CYP-35D1 to produce a reactive electrophile in C. elegans^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	Human cells, fungi, plant beneficial rhizobacteria
Concentration:	50 µM
Incubation Time:	3 days
Result:	Was relatively inactive against non-nematode phyla at the same concentration of killing nematodes in vitro.

In Vivo

Cyprocide-B (60 μM, 24 h) has potential utility in preventing root infestation by M. incognita in a soil environment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

240.71

Formula

C₁₀H₉ClN₂OS

CAS No.

49809-25-8

SMILES

CCSC1=NN=C(C2=CC=C(Cl)C=C2)O1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Knox J, et al. Cyprocide selectively kills nematodes via cytochrome P450 bioactivation[J]. Nat Commun. 2024 Jul 2;15(1):5529. [Content Brief]

Cyprocide-B Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyprocide-B49809-25-8Cytochrome P450ParasiteCYPsnematodeselectrophilic metaboliteC. elegansselective nematicideInhibitorinhibitorinhibit

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