2. Anti-infection
  3. Parasite
  4. Febantel

Febantel is an oral dewormer used to treat gastrointestinal nematodes in sheep, as well as roundworm and tapeworm infections in poultry and livestock, and it also inhibits the embryonic development of mouse hairworms and whipworm eggs.

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Febantel Chemical Structure

Febantel Chemical Structure

CAS No. : 58306-30-2

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Based on 1 publication(s) in Google Scholar

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Febantel Related Antibodies

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Description

Febantel is an oral dewormer used to treat gastrointestinal nematodes in sheep, as well as roundworm and tapeworm infections in poultry and livestock, and it also inhibits the embryonic development of mouse hairworms and whipworm eggs[1][2].

Cellular Effect
Cell Line Type Value Description References
HepG2 EC50
10 μM
Compound: Febantel
Activation of human PXR expressed in human HepG2 (DPX-2) cells assessed as induction of CYP3A4 after 24 hrs by luminescent analysis
Activation of human PXR expressed in human HepG2 (DPX-2) cells assessed as induction of CYP3A4 after 24 hrs by luminescent analysis
[PMID: 20966043]
HepG2 EC50
15.8 μM
Compound: Febantel
Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysis
Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysis
[PMID: 20966043]
HepG2 EC50
31.6 μM
Compound: Febantel
Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysis
Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysis
[PMID: 20966043]
In Vivo

Febantel (500 mg/kg, orally, single dose) is excreted in mice infected with T. muris, preventing the eggs from developing into larvae[1].
Febantel (0.5-2.5 mg/kg, orally, single dose) effectively stops the hatching and development of parasitic eggs in sheep infected with Haemonchus contortus[1].
Pharmacokinetic Parameters of Oral Febantel Metabolites in the non-infected group and infected group[2]

Lambs Metabolite Route Dose (mg/kg) AUC (μg•h/mL) Cmax (μg/mL) Tmax (h)
Uninfected FBZ Oral 7.5 6.555 0.258 8
Uninfected OXF Oral 7.5 18.905 0.613 12
Uninfected OXFSO Oral 7.5 16.040 0.332 16
Infected FBZ Oral 7.5 5.648 0.188 12
Infected OXF Oral 7.5 13.995 0.537 16
Infected OXFSO Oral 7.5 14.659 0.275 16

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: T.muris infected mice[1]
Dosage: 500 mg/kg; single dose
Administration: Oral
Result: Caused most of the eggs that were released after 31 hours to fail to develop into larvae.
Animal Model: Haemonchus contortus sheep[1]
Dosage: 0.5, 1, 2.5 mg/kg; single dose
Administration: Oral
Result: Allowed the isolation of approximately 2,300 larvae from feces within 3 hours after administration; however, only 200 larvae could be isolated 6 hours after administration; and no larvae could be detected after 24 hours.
Molecular Weight

446.48

Formula

C20H22N4O6S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COCC(NC1=CC(SC2=CC=CC=C2)=CC=C1/N=C(NC(OC)=O)\NC(OC)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (223.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2397 mL 11.1987 mL 22.3974 mL
5 mM 0.4479 mL 2.2397 mL 4.4795 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

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Concentration (final)

C2

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Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (5.60 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (5.60 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2397 mL 11.1987 mL 22.3974 mL 55.9935 mL
5 mM 0.4479 mL 2.2397 mL 4.4795 mL 11.1987 mL
10 mM 0.2240 mL 1.1199 mL 2.2397 mL 5.5994 mL
15 mM 0.1493 mL 0.7466 mL 1.4932 mL 3.7329 mL
20 mM 0.1120 mL 0.5599 mL 1.1199 mL 2.7997 mL
25 mM 0.0896 mL 0.4479 mL 0.8959 mL 2.2397 mL
30 mM 0.0747 mL 0.3733 mL 0.7466 mL 1.8665 mL
40 mM 0.0560 mL 0.2800 mL 0.5599 mL 1.3998 mL
50 mM 0.0448 mL 0.2240 mL 0.4479 mL 1.1199 mL
60 mM 0.0373 mL 0.1866 mL 0.3733 mL 0.9332 mL
80 mM 0.0280 mL 0.1400 mL 0.2800 mL 0.6999 mL
100 mM 0.0224 mL 0.1120 mL 0.2240 mL 0.5599 mL
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Febantel Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Febantel58306-30-2ParasitePesticideorallysheepeggsInhibitorinhibitorinhibit

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