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  5. Ascr#7

Ascr#7, an ascaroside, is a hormone of nematodes. Ascr#7 is expressed during nematode development. Ascarosides can induce formation of long-lived and highly stress resistant dauer larvae.

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Ascr#7 Chemical Structure

Ascr#7 Chemical Structure

CAS No. : 1139837-37-8

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5 mg USD 850 In-stock
10 mg USD 1450 In-stock
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Based on 1 publication(s) in Google Scholar

Ascr#7 Related Antibodies

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  • Purity & Documentation

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Description

Ascr#7, an ascaroside, is a hormone of nematodes. Ascr#7 is expressed during nematode development. Ascarosides can induce formation of long-lived and highly stress resistant dauer larvae[1].

In Vitro

Ascarosides are often referred to as "dauer pheromones" because most of them induce formation of long-lived and highly stress resistant dauer larvae[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ascr#7 Related Antibodies
Molecular Weight

274.31

Formula

C13H22O6
CAS No.
Appearance

Viscous Liquid

Color

Colorless to light yellow

SMILES

OC(/C=C/CC[C@@H](C)O[C@H]1[C@@H](C[C@H]([C@@H](O1)C)O)O)=O
Structure Classification
Initial Source

Caenorhabditis Elegans
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (729.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 100 mg/mL (364.55 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6455 mL 18.2276 mL 36.4551 mL
5 mM 0.7291 mL 3.6455 mL 7.2910 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 5 mg/mL (18.23 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (364.55 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.37%

SDS (252 KB)

COA (244 KB) HNMR (183 KB) LCMS (88 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 3.6455 mL 18.2276 mL 36.4551 mL 91.1378 mL
5 mM 0.7291 mL 3.6455 mL 7.2910 mL 18.2276 mL
10 mM 0.3646 mL 1.8228 mL 3.6455 mL 9.1138 mL
15 mM 0.2430 mL 1.2152 mL 2.4303 mL 6.0759 mL
20 mM 0.1823 mL 0.9114 mL 1.8228 mL 4.5569 mL
25 mM 0.1458 mL 0.7291 mL 1.4582 mL 3.6455 mL
30 mM 0.1215 mL 0.6076 mL 1.2152 mL 3.0379 mL
40 mM 0.0911 mL 0.4557 mL 0.9114 mL 2.2784 mL
50 mM 0.0729 mL 0.3646 mL 0.7291 mL 1.8228 mL
60 mM 0.0608 mL 0.3038 mL 0.6076 mL 1.5190 mL
80 mM 0.0456 mL 0.2278 mL 0.4557 mL 1.1392 mL
100 mM 0.0365 mL 0.1823 mL 0.3646 mL 0.9114 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Ascr#7 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ascr#71139837-37-8OthersascarosidehormonenematodesInhibitorinhibitorinhibit

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