2. Anti-infection Apoptosis
  3. Parasite Apoptosis
  4. Oxibendazole

Oxibendazole is an effective benzimidazole anthelmintic and is against nema-tode infections. Oxibendazole can induces apoptosis and has anti-cancer and anti-inflammation activities.

For research use only. We do not sell to patients.

Oxibendazole Chemical Structure

Oxibendazole Chemical Structure

CAS No. : 20559-55-1

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Based on 2 publication(s) in Google Scholar

Other Forms of Oxibendazole:

Oxibendazole Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Oxibendazole is an effective benzimidazole anthelmintic and is against nema-tode infections. Oxibendazole can induces apoptosis and has anti-cancer and anti-inflammation activities[1][2].

In Vitro

Cell proliferation decreased in both porcine trophectoder (pTr) and Porcine luminal epithelial (pLE) cells in response to Oxibendazole, and we determines that this is modulated through intracellular cell signal transduction. Phosphorylation of ERK1/2, P90RSK, and S6 are downregulated by exposure to a 200 nM dose of Oxibendazole in both types of cells, while the expression of phosphorylated JNK, AKT, and P70S6K is upregulated[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Oxibendazole Related Antibodies
In Vivo

The mean size of 22Rv1 tumors in nude mice treated with Oxibendazole (25 mg/kg/day) is 47.96% smaller than that of the control mice. Treatment with Oxibendazole increases the expression of microRNA-204 (miR-204)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

249.27

Formula

C12H15N3O3
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C(OC)NC1=NC2=CC=C(OCCC)C=C2N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (20.06 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0117 mL 20.0586 mL 40.1171 mL
5 mM 0.8023 mL 4.0117 mL 8.0234 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.0117 mL 20.0586 mL 40.1171 mL 100.2929 mL
5 mM 0.8023 mL 4.0117 mL 8.0234 mL 20.0586 mL
10 mM 0.4012 mL 2.0059 mL 4.0117 mL 10.0293 mL
15 mM 0.2674 mL 1.3372 mL 2.6745 mL 6.6862 mL
20 mM 0.2006 mL 1.0029 mL 2.0059 mL 5.0146 mL
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Oxibendazole Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oxibendazole20559-55-1ParasiteApoptosisInhibitorinhibitorinhibit

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