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proteinase-3

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By Targets:	Bacterial (1) Cathepsin (1) Elastase (3) Ser/Thr Protease (1)
By Research Areas:	Infection (2) Inflammation/Immunology (1)

4

Inhibitors & Agonists

3

Peptides

8

Recombinant Proteins

Targets Recommended: Procollagen C Proteinase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

CE-2072	Ser/Thr Protease	Infection
CE-2072 is an inhibitor of serine proteases neutrophil elastase and *proteinase-3. CE-2072 inhibits HIV-1* production and p24 production in response to IL-18 or NaCl in infected U1 monocytic cells, reduces virus replication in infected peripheral blood mononuclear cells and blocks infection of permissive HeLa cells. CE-2072 suppresses activation of the HIV-1-inducing transcription factor NF-kB in U1 cells. CE-2072 is promising for research of HIV-1-related disease .

MeOSuc-AAPV-CMK Elastase Inhibitor III	Elastase Cathepsin	Others
MeOSuc-AAPV-CMK (Elastase Inhibitor III) is an elastase inhibitor. MeOSuc-AAPV-CMK also inhibits cathepsin G and *proteinase 3*.MeOSuc-AAPV-CMK blocks the cleavage of adiponectin by leukocyte elastase .

Elafin(human)	Bacterial Elastase	Infection
Elafin,also known as elafin-specific inhibitor (ESI) or skin anti-leucoprotease (SKALP), is a low molecular weight inhibitor of human neutrophil elastase (HNE) and proteinase 3 in lung. Elafin is antibiotic against Pseudomonas aeruginosa and Staphylococcus aureus ^[3].

Neutrophil elastase inhibitor 5	Elastase	Inflammation/Immunology
Neutrophil elastase inhibitor 5 (compound 29) is a dual inhibitor of HNE (human neutrophil elastase) and proteinase 3 (PR3) with IC₅₀ values of 4.91 μM and 20.69 μM, respectively. Neutrophil elastase inhibitor 5 can be used in the study of neutrophil inflammatory diseases .

Cat. No.	Product Name	Target	Research Area

Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp	Peptides	Others
Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp is a fluorescence-quenched peptide substrate for human *proteinase 3* (k_cat/K_m = 1,570 mM ^-1s ^-1), and can be used for detection of proteinase 3 (PR3) activity .

MeOSuc-AAPV-CMK Elastase Inhibitor III	Elastase Cathepsin	Others
MeOSuc-AAPV-CMK (Elastase Inhibitor III) is an elastase inhibitor. MeOSuc-AAPV-CMK also inhibits cathepsin G and *proteinase 3*.MeOSuc-AAPV-CMK blocks the cleavage of adiponectin by leukocyte elastase .

Elafin(human)	Bacterial Elastase	Infection
Elafin,also known as elafin-specific inhibitor (ESI) or skin anti-leucoprotease (SKALP), is a low molecular weight inhibitor of human neutrophil elastase (HNE) and proteinase 3 in lung. Elafin is antibiotic against Pseudomonas aeruginosa and Staphylococcus aureus ^[3].

Species:	Human (3) Virus (5)
Tag:	His (8) Avi (2)
Source:	HEK293 (3) Sf9 insect cells (2) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

	*PRTN3 Protein, Human (HEK293, His)* Myeloblastin; AGP7; C-ANCA Antigen; Leukocyte proteinase 3; PR-3; PR3; Neutrophil proteinase 4; NP-4; P29; Wegener Autoantigen; PRTN3; MBN	Human	HEK293
	PRTN3 is a serine protease that broadly targets elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV in vitro, playing a crucial role in extracellular matrix degradation. It modulates endothelial cell barrier function by cleaving and activating the receptor F2RL1/PAR-2 and enhances vascular integrity during neutrophil transendothelial migration. PRTN3 Protein, Human (HEK293, His) is the recombinant human-derived PRTN3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PRTN3 Protein, Human (HEK293, His) is 224 a.a., with molecular weight of ~34.0 kDa.

	*PRTN3 Protein, Human (HEK293, C-His)* Myeloblastin; AGP7; C-ANCA Antigen; Leukocyte proteinase 3; PR-3; PR3; Neutrophil proteinase 4; NP-4; P29; Wegener Autoantigen; PRTN3; MBN	Human	HEK293
	PRTN3 is a serine protease that broadly targets elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV in vitro, playing a crucial role in extracellular matrix degradation.It modulates endothelial cell barrier function by cleaving and activating the receptor F2RL1/PAR-2 and enhances vascular integrity during neutrophil transendothelial migration.PRTN3 Protein, Human (HEK293, C-His) is the recombinant human-derived PRTN3 protein, expressed by HEK293 , with C-6*His labeled tag.

	*SARS-CoV-2 3C-like Proteinase* (His)** M proteinase; 3CL proteinase; 2019-nCoV 3C-like proteinase	Virus	E. coli
	SARS-CoV-2 3C-like Proteinase (His), His, expressed in E.coli, mediates viral polyprotein maturation and multiple cleavages of host proteins to modulate viral translation and transcription with a His tag at the N-terminus.

	*SARS-CoV-2 3C-like Proteinase* (N-His)** M proteinase; 3CL proteinase; 2019-nCoV 3C-like proteinase	Virus	E. coli
	SARS-CoV-2 3C-like Proteinase (His), His, expressed in E.coli, mediates viral polyprotein maturation and multiple cleavages of host proteins to modulate viral translation and transcription with a His tag at the N-terminus.

	*PRTN3 Protein, Human (S203A, HEK293, His)* Myeloblastin; AGP7; Leukocyte proteinase 3; PR-3; P29; Wegener autoantigen; MBN	Human	HEK293
	PRTN3, a serine protease, broadly targets elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV in vitro, playing a crucial role in extracellular matrix degradation. It modulates endothelial cell barrier function by cleaving and activating the receptor F2RL1/PAR-2, enhancing vascular integrity during neutrophil transendothelial migration. Its potential involvement in this process, particularly when associated with CD177, underscores its significance in immune-related functions. PRTN3 Protein, Human (S203A, HEK293, His) is the recombinant human-derived PRTN3 protein, expressed by HEK293 , with C-His labeled tag and I28-P256 mutation. The total length of PRTN3 Protein, Human (S203A, HEK293, His) is 229 a.a., with molecular weight of ~26.57 kDa.

	*SARS-CoV-2 3CLpro/3C-like protease Protein* (His-Avi)** 3CL Protease; 3CL proteinase; 3C-like main protease; 3CL-Mpro; COVID-19; M proteinase; Main Protease; Mpro	Virus	E. coli
	SARS-CoV-2 3CLpro/3C-like protease Protein (His-Avi) is the recombinant Virus-derived SARS-CoV-2 3CLpro/3C-like protease protein, expressed by E. coli , with N-His, N-Avi labeled tag. The total length of SARS-CoV-2 3CLpro/3C-like protease Protein (His-Avi) is 306 a.a., with molecular weight of ~36.5 kDa.

	*SARS-CoV-2 3CLpro/3C-like protease Protein* (sf9, His)** 3CL Protease; 3CL proteinase; 3C-like main protease; 3CL-Mpro; COVID-19; M proteinase; Main Protease; Mpro	Virus	Sf9 insect cells
	SARS-CoV-2 3CLpro/3C-like protease Protein (sf9, His) is the recombinant Virus-derived SARS-CoV-2 3CLpro/3C-like protease protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of SARS-CoV-2 3CLpro/3C-like protease Protein (sf9, His) is 306 a.a., with molecular weight of ~37 kDa.

	*SARS-CoV-2 3CLpro/3C-like protease Protein* (sf9, His-Avi)** 3CL Protease; 3CL proteinase; 3C-like main protease; 3CL-Mpro; COVID-19; M proteinase; Main Protease; Mpro	Virus	Sf9 insect cells
	SARS-CoV-2 3CLpro/3C-like protease Protein (sf9, His-Avi) is the recombinant Virus-derived SARS-CoV-2 3CLpro/3C-like protease protein, expressed by Sf9 insect cells , with N-His, N-Avi labeled tag. The total length of SARS-CoV-2 3CLpro/3C-like protease Protein (sf9, His-Avi) is 306 a.a., with molecular weight of ~37.1 kDa.

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