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telomerase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Telomerase (31) ADC Cytotoxin (1) Antibiotic (2) Apoptosis (13) Cholinesterase (ChE) (1) CMV (2) Cytochrome P450 (2) DNA/RNA Synthesis (5) Dopamine β-hydroxylase (2) EBV (2) Ferroptosis (1) G-quadruplex (5) Histone Acetyltransferase (1) HIV (6) HIV Protease (2) Influenza Virus (2) Monoamine Oxidase (2) PKC (2) Reverse Transcriptase (8) SARS-CoV (1)
By Research Areas:	Cancer (33) Endocrinology (1) Infection (11) Inflammation/Immunology (4) Metabolic Disease (2) Neurological Disease (6)

Inhibitors & Agonists

Screening Libraries

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Antibodies

Targets Recommended: Telomerase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-126483

Telomerase-IN-3	Telomerase	Cancer
Telomerase-IN-3 is a *telomerase* inhibitor, which directly targets hTERT promoter activity. hTERT is the key component for maintenance of telomerase activity .

HY-126482

Telomerase-IN-2	Telomerase	Cancer
Telomerase-IN-2 is a *telomerase* inhibitor, and inhibits telomerase activity by decreasing expression of dyskerin, with an IC₅₀ of 0.89 µM. Anti-cancer activity .

HY-U00268

Telomerase-IN-1	Telomerase	Cancer
Telomerase-IN-1 is a *Telomerase* inhibitor with an IC₅₀ of 0.19 μM.

HY-120145

MST-312 telomerase Inhibitor IX	Telomerase	Cancer
MST-312 is a *telomerase* inhibitor. MST-312 is a chemically modified derivative of green tea epigallocatechin gallate (EGCG). MST-312 can be used for the research of cancer, such as multiple myeloma (MM) .

HY-15523

Braco-19 4 Publications Verification	CMV DNA/RNA Synthesis	Cancer
Braco-19 is a potent telomerase/telomere* inhibitor,* preventing the capping and catalytic action of telomerase. Braco-19 acts as G-quadruplex (GQ) binding ligand, stabilizing G-quadruplexes formation at the 3V telomeric DNA overhang and produce rapid senescence or selective cell death. Braco-19 is also a HAdV virus replication inhibitor .

HY-163914

Telomerase-IN-7	Telomerase	Cancer
Telomerase-IN-7 (compound 9) is a *Telomerase* inhibitor with an IC₅₀ of 0.03 μM .

HY-152076

Telomerase-IN-4	Apoptosis	Cancer
Telomerase-IN-4 is a potent *telomerase* inhibitor. Telomerase-IN-4 has antiproliferative activity and induces apoptosis .

HY-152077

Telomerase-IN-5	Apoptosis	Cancer
Telomerase-IN-5 is a potent *telomerase* inhibitor. Telomerase-IN-5 has antiproliferative activity and induces apoptosis .

HY-163137

Telomerase-IN-6	Telomerase	Cancer
Telomerase-IN-6（6f）is a *telomerase* inhibitor with antitumor activity .

HY-148200

L2H2-6OTD	ADC Cytotoxin Telomerase	Cancer
L2H2-6OTD, containing one to four G-quadruplex binding loops, is a telomeric inhibitor analogue. l2H2-6OTD has *telomerase* inhibitory activity with an IC₅₀ value of 15 nM .

HY-15523A

Braco-19 trihydrochloride 4 Publications Verification	DNA/RNA Synthesis CMV	Infection Cancer
Braco-19 trihydrochloride is a potent telomerase/telomere* inhibitor,* preventing the capping and catalytic action of telomerase. Braco-19 acts as G-quadruplex (GQ) binding ligand, stabilizing G-quadruplexes formation at the 3V telomeric DNA overhang and produce rapid senescence or selective cell death. Braco-19 is also a HAdV virus replication inhibitor .

HY-113679

Ceramides Mixture 1 Publications Verification	Telomerase	Metabolic Disease Endocrinology
Ceramides Mixture is an endogenous ceramide and consists of hydroxy and non-hydroxy fatty acid-containing ceramides. Ceramides Mixture is a main lipid component of the permeability barrier in epidermis. Ceramides Mixture is involved in the regulation of growth inhibition, cell cycle arrest, and modulation of *telomerase* activity .

HY-137817

BCH001	DNA/RNA Synthesis	Metabolic Disease
BCH001, a quinoline derivative, is a specific PAPD5 inhibitor. BCH001 restores telomerase activity and telomere length in dyskeratosis congenita (DC) induced pluripotent stem cells. BCH001 shows no inhibition of poly(A)-specific ribonuclease (PARN) or several other canonical and non-canonical polynucleotide polymerases. BCH001 is used to regulate aging .

HY-15595

360A	G-quadruplex Telomerase	Cancer
360A is a selective stabilizer of G-quadruplex, and also inhibits *telomerase* activity with an IC₅₀ of 300 nM for telomerase in TRAP-G4 assay.

HY-15595A

360A iodide 2 Publications Verification 360 A iodide	G-quadruplex Telomerase	Cancer
360A iodide is a selective stabilizer of G-quadruplex, and also inhibits *telomerase* activity with an IC₅₀ of 300 nM for telomerase in TRAP-G4 assay.

HY-N0453

Hypericin 3 Publications Verification	Apoptosis Influenza Virus Antibiotic Monoamine Oxidase PKC Cytochrome P450 Dopamine β-hydroxylase Reverse Transcriptase Telomerase	Infection Neurological Disease Cancer
Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis .

HY-17353

BIBR 1532 5 Publications Verification	Telomerase Apoptosis	Cancer
BIBR 1532 is a potent, selective and non-competitive telomerase* inhibitor* with IC₅₀ of 100 nM in a cell-free assay.

HY-18762

6-Thio-2'-Deoxyguanosine 6-thio-dG; β-TGdR	DNA/RNA Synthesis	Cancer
6-Thio-2'-Deoxyguanosine is a nucleoside analogue that can be incorporated into de novo-synthesized telomeres by telomerase.

HY-101089

RHPS4	Telomerase Apoptosis	Cancer
RHPS4 is a potent *telomerase* inhibitor (IC₅₀ = 0.33 μM). RHPS4 is a DNA damage inducer .

HY-48625

L2H2-6OTD intermediate-2	Telomerase	Cancer
L2H2-6OTD intermediate-2 is an intermediate of telomerase inhibitor, which can be used in the synthesis of ADC .

HY-16706A

Remodelin hydrobromide Maximum Cited Publications 10 Publications Verification	Histone Acetyltransferase	Cancer
Remodelin hydrobromide is an orally active and selective inhibitor of acetyltransferase NAT10. Remodelin hydrobromide inhibits NAT10 activitity and slows DNA replication and suppresses growth of prostate cancer cells. Remodelin hydrobromide inhibits the growth of prostate cancer and hepatocellular carcinoma in xenograft model. Remodelin hydrobromide enhances the healthspan in hutchinson-gilford progeria syndrome (HGPS) mouse model .

HY-W250161

7-Deaza-2′-deoxyguanosine 5′-triphosphate 7-Deaza-2'-dGTP	Telomerase	Cancer
7-Deaza-2′-deoxyguanosine 5′-triphosphate (7-Deaza-2'-dGTP), a nucleotide analogue, is a *telomerase* inhibitor (IC₅₀: 11 μM) .

HY-P1149

Epitalon Epithalon; Epithalamin	Telomerase	Neurological Disease Cancer
Epitalon is an anti-aging agent and a telomerase activator. Epitalon has an inhibitory effect of the on the development of spontaneous tumors in mice, has geroprotective actions and intranasal administration increases neuronal activity. Epitalon can be used for cancer, old age and Retinitis Pigmentosa .

HY-17423

Abacavir 3 Publications Verification	HIV Reverse Transcriptase Telomerase Apoptosis	Infection Cancer
Abacavir is an orally active and competitive nucleoside reverse transcriptase inhibitor. Abacavir can inhibits the replication of HIV. Abacavir shows anticancer activity in prostate cancer cell lines. Abacavir can trespass the blood-brain-barrier and suppresses *telomerase* activity .

HY-17423E

Abacavir hydrochloride	HIV Apoptosis Reverse Transcriptase Telomerase	Infection Cancer
Abacavir hydrochloride is a competitive, orally active nucleoside reverse transcriptase inhibitor. Abacavir hydrochloride can inhibits the replication of HIV. Abacavir hydrochloride shows anticancer activity in prostate cancer cell lines. Abacavir hydrochloride can trespass the blood-brain-barrier and suppresses *telomerase* activity .

HY-P1149A

Epitalon TFA Epithalon TFA; Epithalamin TFA	Telomerase	Neurological Disease Cancer
Epitalon TFA is an anti-aging agent and a telomerase activator. Epitalon TFA has an inhibitory effect of the on the development of spontaneous tumors in mice, has geroprotective actions and intranasal administration increases neuronal activity. Epitalon TFA can be used for cancer, old age and Retinitis Pigmentosa .

HY-N2006

Ganoderic acid B	EBV HIV Protease	Infection Inflammation/Immunology
Ganoderic acid B is a triterpene isolated from a mushroom Ganoderma lucidum. Ganoderic acid B inhibits the activation of Epstein-Barr virus (EBV) antigens as telomerase inhibitor. Ganoderic acid B is a moderately active inhibitor against HIV-1 protease (IC₅₀: 170 μM) .

HY-17423B

Abacavir monosulfate	HIV Reverse Transcriptase Telomerase Apoptosis	Infection Cancer
Abacavir monosulfate is a competitive, orally active nucleoside reverse transcriptase inhibitor. Abacavir monosulfate can inhibits the replication of HIV. Abacavir monosulfate shows anticancer activity in prostate cancer cell lines. Abacavir monosulfate can trespass the blood-brain-barrier and suppresses *telomerase* activity .

HY-148200A

L2H2-6OTD diformic	Telomerase	Cancer
L2H2-6OTD acetate contains one to four G-quadruplex binding loops and is a telomere inhibitor analog. L2H2-6OTD acetate has telomerase inhibitory activity with an IC₅₀ value of 15 nM .

HY-17423A

Abacavir sulfate 3 Publications Verification Abacavir Hemisulfate; ABC sulfate	Reverse Transcriptase HIV Telomerase Apoptosis	Infection
Abacavir sulfate (Abacavir Hemisulfate) is a competitive, orally active nucleoside reverse transcriptase inhibitor. Abacavir sulfate can inhibits the replication of HIV. Abacavir sulfate shows anticancer activity in prostate cancer cell lines. Abacavir sulfate can trespass the blood-brain-barrier and suppresses *telomerase* activity .

HY-135775

BMVC 1 Publications Verification	G-quadruplex Telomerase DNA/RNA Synthesis	Cancer
BMVC is a potent G-quadruplex (G4) stabilizer and a selective *telomerase* inhibitor with an IC₅₀ of ~0.2 μM. BMVC inhibits Taq DNA polymerase with an IC₅₀ of ~2.5 μM. BMVC increases the melting temperature of G4 structure of telomere and accelerates telomere length shortening. Anticancer activities .

HY-N1485

Cycloastragenol 5 Publications Verification Astramembrangenin; Cyclosieversigenin	Telomerase	Neurological Disease Inflammation/Immunology
Cycloastragenol (Astramembrangenin), the active form of astragaloside IV, has anti-oxidant, anti-inflammatory, anti-aging, anti-apoptotic, and cardiovascular protective effects. Cycloastragenol is a potent *telomerase* activator and can lengthen telomeres. Cycloastragenol alleviates age-related bone loss and improves bone microstructure and biomechanical properties .

HY-129334

Macrocalin B	Telomerase	Cancer
Macrocalin B is a diterpenoid, which can be isolated from Isodon xerophilus. Macrocalin B inhibits the proliferation of cancer cells K562, HL-60, A549, MKN, CA and HCT with IC₅₀ of 2.81-171 μM. Macrocalin B inhibits the *telomerase* in K562 with an IC₅₀ in nanomolar level .

HY-17423R

Abacavir (Standard)	HIV Reverse Transcriptase Telomerase Apoptosis	Infection Cancer
Abacavir (Standard) is the analytical standard of Abacavir. This product is intended for research and analytical applications. Abacavir is an orally active and competitive nucleoside reverse transcriptase inhibitor. Abacavir can inhibits the replication of HIV. Abacavir shows anticancer activity in prostate cancer cell lines. Abacavir can trespass the blood-brain-barrier and suppresses *telomerase* activity .

HY-N0453R

Hypericin (Standard) 3 Publications Verification	Apoptosis Influenza Virus Antibiotic Monoamine Oxidase PKC Cytochrome P450 Dopamine β-hydroxylase Reverse Transcriptase Telomerase	Infection Neurological Disease Cancer
Hypericin (Standard) is the analytical standard of Hypericin. This product is intended for research and analytical applications. Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis .

HY-N2006R

Ganoderic acid B (Standard)	EBV HIV Protease	Infection Inflammation/Immunology
Ganoderic acid B (Standard) is the analytical standard of Ganoderic acid B. This product is intended for research and analytical applications. Ganoderic acid B is a triterpene isolated from a mushroom Ganoderma lucidum. Ganoderic acid B inhibits the activation of Epstein-Barr virus (EBV) antigens as telomerase inhibitor. Ganoderic acid B is a moderately active inhibitor against HIV-1 protease (IC₅₀: 170 μM) .

HY-108477

TMPyP4 tosylate 2 Publications Verification TMP 1363	G-quadruplex Telomerase Cholinesterase (ChE) SARS-CoV	Cancer
TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand. TMPyP4 tosylate inhibits the interaction between G-quadruplexes and IGF-1. TMPyP4 tosylate is a *telomerase* inhibitor and inhibits cancer cells proliferation. TMPyP4 tosylate is also a stabilizer of nucleic acid secondary structure and an acetylcholinesterase inhibitor. Besides, TMPyP4 tosylate has antiviral activity against SARS-CoV-2 .

HY-N1485R

Cycloastragenol (Standard)	Telomerase	Neurological Disease Inflammation/Immunology
Cycloastragenol (Standard) is the analytical standard of Cycloastragenol. This product is intended for research and analytical applications. Cycloastragenol (Astramembrangenin), the active form of astragaloside IV, has anti-oxidant, anti-inflammatory, anti-aging, anti-apoptotic, and cardiovascular protective effects. Cycloastragenol is a potent telomerase activator and can lengthen telomeres. Cycloastragenol alleviates age-related bone loss and improves bone microstructure and biomechanical properties .

HY-48517

L2H2-6OTD intermediate-1	Others	Cancer
L2H2-6OTD intermediate-1 is an intermediate for the synthesis of L2H2-6OTD (HY-148200) and can be used for ADC preparation. L2H2-6OTD, a telomestatin analog with telomerase inhibitory activity (IC₅₀: 15 nM) .

HY-48626

L2H2-6OTD intermediate-3	Others	Others
L2H2-6OTD intermediate-3 is an intermediate for the synthesis of L2H2-6OTD (HY-148200) and can be used for ADC preparation. L2H2-6OTD, a telomestatin analog with telomerase inhibitory activity (IC₅₀: 15 nM) .

HY-17423AR

Abacavir sulfate (Standard)	Reverse Transcriptase HIV Telomerase Apoptosis	Infection
Abacavir (sulfate) (Standard) is the analytical standard of Abacavir (sulfate). This product is intended for research and analytical applications. Abacavir sulfate (Abacavir Hemisulfate) is a competitive, orally active nucleoside reverse transcriptase inhibitor. Abacavir sulfate can inhibits the replication of HIV. Abacavir sulfate shows anticancer activity in prostate cancer cell lines. Abacavir sulfate can trespass the blood-brain-barrier and suppresses telomerase activity .

HY-162688

Anticancer agent 239	Telomerase G-quadruplex Apoptosis Ferroptosis	Others
Anticancer agent 239 (Compound 5) is a ligand of hTERT promoter G-quadruplex DNA structures (hTERT G4) (K_d = 1.1 μM), and downregulates hTERT expression. Anticancer agent 239 decreases telomerase activity, shortens telomere length, and induces DNA damage, acute cellular senescence, and apoptosis. Anticancer agent 239 causes mitochondrial dysfunction, disrupts iron metabolism and activates ferroptosis in cancer cells. Anticancer agent 239 inhibits tumor growth in MDA-MB-231 xenograft mouse model .

Cat. No.	Product Name

HY-L034

Anti-Aging Compound Library	4,757 compounds
Aging is a complex biological process characterized by functional decline of tissues and organs, structural degeneration, and reduced adaptability and resistance, all of which contribute to an increase in morbidity and mortality caused by multiple chronic diseases, such as Alzheimer's disease, cancer, and diabetes. Many theories, which fall into two main categories: programmed and error theories, have been proposed to explain the process of aging, but neither of them appears to be fully satisfactory. The programmed theories imply that aging relies on specific gene regulation, and the error theories emphasize the internal and environmental damages accumulated to living organisms. The damage theories proposed the nine hallmarks that were generally considered to contribute to the aging process: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. MCE Anti-Aging Compound Library contains 4,757 compounds, mainly targeting Sirtuin, mTOR, IGF-1R, AMPK, p53, Telomerase, Mitophagy, Mitochondrial Metabolism, COX, Cytochrome P450, Oxidase, etc. This library is a useful tool for anti-aging research.

Anti-Aging Compound Library

4,757 compounds

Aging is a complex biological process characterized by functional decline of tissues and organs, structural degeneration, and reduced adaptability and resistance, all of which contribute to an increase in morbidity and mortality caused by multiple chronic diseases, such as Alzheimer's disease, cancer, and diabetes. Many theories, which fall into two main categories: programmed and error theories, have been proposed to explain the process of aging, but neither of them appears to be fully satisfactory. The programmed theories imply that aging relies on specific gene regulation, and the error theories emphasize the internal and environmental damages accumulated to living organisms. The damage theories proposed the nine hallmarks that were generally considered to contribute to the aging process: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication.

MCE Anti-Aging Compound Library contains 4,757 compounds, mainly targeting Sirtuin, mTOR, IGF-1R, AMPK, p53, Telomerase, Mitophagy, Mitochondrial Metabolism, COX, Cytochrome P450, Oxidase, etc. This library is a useful tool for anti-aging research.

Cat. No.	Product Name	Type

HY-W543137

PT-ttpy	Biochemical Assay Reagents
Pt-ttpy, a metallo-organic complex and potent G-quadruplex ligand, effectively triggers substantial telomere-related DNA damage in cancer cells by inhibiting telomerase and/or telomere functions, while also causing various chromatin abnormalities during mitosis, such as chromatin bridges, ultrafine bridges (UFBs), and double-stranded breaks (DSBs).

Cat. No.	Product Name	Target	Research Area

HY-P1149

Epitalon Epithalon; Epithalamin	Telomerase	Neurological Disease Cancer
Epitalon is an anti-aging agent and a telomerase activator. Epitalon has an inhibitory effect of the on the development of spontaneous tumors in mice, has geroprotective actions and intranasal administration increases neuronal activity. Epitalon can be used for cancer, old age and Retinitis Pigmentosa .

HY-P1149A

Epitalon TFA Epithalon TFA; Epithalamin TFA	Telomerase	Neurological Disease Cancer
Epitalon TFA is an anti-aging agent and a telomerase activator. Epitalon TFA has an inhibitory effect of the on the development of spontaneous tumors in mice, has geroprotective actions and intranasal administration increases neuronal activity. Epitalon TFA can be used for cancer, old age and Retinitis Pigmentosa .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81110

	TERT Antibody telomerase catalytic subunit; EST2; hEST2; TCS1; telomerase associated protein 2; Telomere Reverse Transcriptase; TP2; TRT; telomerase reverse transcriptase; telomerase Catalytic Subunit; telomerase-associated protein 2; TERT_HUMAN.	WB, ELISA, IHC-P, IHC-F, FC, ICC/IF,	Human, Mouse, Rat,
	TERT Antibody is an unconjugated, approximately 125 kDa, rabbit-derived, anti-TERT polyclonal antibody. TERT Antibody can be used for: WB, ELISA, IHC-P, IHC-F, Flow-Cyt, ICC, IF expriments in human, mouse, rat, background without labeling.

HY-P83386

	p23 Antibody (YA3131) PTGES3; P23; TEBP; Prostaglandin E synthase 3; Cytosolic prostaglandin E2 synthase; cPGES; Hsp90 co-chaperone; Progesterone receptor complex p23; telomerase-binding protein p23	WB, ICC/IF, IP	Human, Mouse, Rat
	p23 Antibody (YA3131) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3131), targeting p23, with a predicted molecular weight of 19 kDa (observed band size: 23 kDa). p23 Antibody (YA3131) can be used for WB, ICC/IF, IP experiment in human, mouse, rat background.

HY-P81110A

	TERT Antibody (YA3439) telomerase catalytic subunit; EST2; hEST2; TCS1; telomerase associated protein 2; Telomere Reverse Transcriptase; TP2; TRT; telomerase reverse transcriptase; telomerase Catalytic Subunit; telomerase-associated protein 2; TERT_HUMAN.	WB, IHC-P, FC	Human
	TERT Antibody is an unconjugated, approximately 125 kDa, rabbit-derived, anti-TERT monoclonal antibody. TERT Antibody can be used for: WB, IHC-P, Flow-Cyt expriments in human background without labeling.

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