L2H2-6OTD

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L2H2-6OTD, containing one to four G-quadruplex binding loops, is a telomeric inhibitor analogue. l2H2-6OTD has telomerase inhibitory activity with an IC₅₀ value of 15 nM.

For research use only. We do not sell to patients.

L2H2-6OTD Chemical Structure

CAS No. : 1016263-75-4

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1 mg	USD 980	Ask For Quote & Lead Time
5 mg	USD 2800	Ask For Quote & Lead Time

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Other Forms of L2H2-6OTD:

L2H2-6OTD diformic Get quote

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Biological Activity
Purity & Documentation
References
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Description

L2H2-6OTD, containing one to four G-quadruplex binding loops, is a telomeric inhibitor analogue. l2H2-6OTD has telomerase inhibitory activity with an IC₅₀ value of 15 nM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
KB 3-1	IC₅₀	> 10 μM Compound: 6c	Cytotoxicity against wild type human KB3-1 cells after 4 days by MTT assay Cytotoxicity against wild type human KB3-1 cells after 4 days by MTT assay	[PMID: 20409709]
KB-V1	IC₅₀	> 10 μM Compound: 6c	Cytotoxicity against multidrug-resistant human KBV1 cells expressing MDR1 after 4 days by MTT assay Cytotoxicity against multidrug-resistant human KBV1 cells expressing MDR1 after 4 days by MTT assay	[PMID: 20409709]

Molecular Weight

658.62

Formula

C₃₀H₃₀N₁₀O₈

CAS No.

1016263-75-4

SMILES

NCCCC[C@H](NC(C1=COC(C2=COC3=N2)=N1)=O)C4=NC(C5=NC(C6=NC(C(N[C@H](C7=NC3=CO7)CCCCN)=O)=CO6)=CO5)=CO4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Keisuke Iida, et al. Evaluation of the interaction between long telomeric DNA and macrocyclic hexaoxazole (6OTD) dimer of a G-quadruplex ligand. Molecules. 2013 Apr 12;18(4):4328-41. [Content Brief]

L2H2-6OTD Related Classifications

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L2H2-6OTD1016263-75-4ADC CytotoxinTelomeraseADC Payloadtelomerasefour G-quadruplexInhibitorinhibitorinhibit

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