2. Apoptosis
  3. Apoptosis
  4. Telomerase-IN-4

Telomerase-IN-4 is a potent telomerase inhibitor. Telomerase-IN-4 has antiproliferative activity and induces apoptosis.

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Telomerase-IN-4 Chemical Structure

Telomerase-IN-4 Chemical Structure

CAS No. : 2892295-10-0

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Telomerase-IN-4 Related Antibodies

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Description

Telomerase-IN-4 is a potent telomerase inhibitor. Telomerase-IN-4 has antiproliferative activity and induces apoptosis[1].

In Vitro

Telomerase-IN-4 (compound 8e; 0.1-100 μg/mL; 72 h) has antitumor effects against both cancer cell lines with IC50 values of 9.47 and 17.09 μg/mL for MCF-7 and A549 cells, respectively[1].
Telomerase-IN-4 (9.467 μg/mL; 48 h) arrests cell cycle at the S phase and induces apoptosis in MCF-7 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Telomerase-IN-4 Related Antibodies

Cell Viability Assay[1]

Cell Line: MCF-7 and A549 cells
Concentration: 0.1, 1, 10, and 100 μg/mL
Incubation Time: 72 h
Result: Inhibited cell growth in a dose-dependent manner.

Apoptosis Analysis[1]

Cell Line: MCF-7 cells
Concentration: 9.467 μg/mL
Incubation Time: 48 h
Result: Had an apoptosis percentage of 42.51%.

Cell Cycle Analysis[1]

Cell Line: MCF-7 cells
Concentration: 9.467 μg/mL
Incubation Time: 48 h
Result: Arrested cell cycle at the S phase of cell growth by more than 1.46 folds compared to that of the control.

Western Blot Analysis[1]

Cell Line: MCF-7 cells
Concentration: 9.467 μg/mL
Incubation Time: 48 h
Result: Decreased in ALT and AST levels by 36.12 and 29.77%, respectively.
In Vivo

Telomerase-IN-4 (5 mg/kg; i.p.; three times per week for two weeks; Swiss albino female mice) has anticancer activity and inhibits tumor growth[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss albino female mice (25-30 g)[1]
Dosage: 5 mg/kg
Administration: Intraperitoneal injectionthree; times per week for two weeks
Result: Reduced both the weight and volume of the tumor by 74.34 and 62.12%, respectively.
Molecular Weight

406.52

Formula

C21H18N4OS2
CAS No.
SMILES

O=C(NC1=C(C#N)C2=C(CCC2)S1)CSC3=NN=C(C=C3)C4=CC=C(C=C4)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Telomerase-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Telomerase-IN-42892295-10-0ApoptosisantiproliferativetumorMCF-7A549S phaseInhibitorinhibitorinhibit

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